The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling
Open accessAbstract
Summary Within the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer-nerve partnership. We find that Dclk1+ tuft cells and nerves are the main sources of acetylcholine (ACh) within the gastric mucosa. Cholinergic stimulation of the gastric epithelium induced nerve growth factor (NGF) expression, and in turn NGF overexpression within gastric epithelium expanded enteric nerves and promoted carcinogenesis. Ablation of Dclk1+ cells or blockade of NGF/Trk signaling inhibited epithelial proliferation and tumorigenesis in a muscarinic acetylcholine receptor-3 (M3R)-dependent manner, in part through suppression of Yes-Associated Protein (YAP) function. This feed-forward ACh-NGF axis activates the gastric cancer niche and offers a compelling target for tumor treatment and prevention.
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A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling
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Roadmap for the Emerging Field of Cancer Neuroscience
Monje, M., Borniger, J. C., D’Silva, N. J., Deneen, B., Dirks, P. B., Fattahi, F., Frenette, P. S., Garzia, L., Gutmann, D. H., Hanahan, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.034 · Cited by 380
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Metadata
- Authors
- Hayakawa, Y., Sakitani, K., Konishi, M., Asfaha, S., Niikura, R., Tomita, H., Renz, B. W., Tailor, Y., Macchini, M., Middelhoff, M., Jiang, Z., Tanaka, T., Dubeykovskaya, Z. A., Kim, W., Chen, X., Urbanska, A. M., Nagar, K., Westphalen, C. B., Quante, M., Lin, C.-S., Gershon, M. D., Hara, A., Zhao, C.-M., Chen, D., Worthley, D. L., Koike, K., & Wang, T. C.
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 31
- Issue
- 1
- Pages
- 21-34
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2562236228
- Cited by
- 573
- References
- 61
- FWCI
- 22.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hayakawa, Y., Sakitani, K., Konishi, M., Asfaha, S., Niikura, R., Tomita, H., Renz, B. W., Tailor, Y., Macchini, M., Middelhoff, M., Jiang, Z., Tanaka, T., Dubeykovskaya, Z. A., Kim, W., Chen, X., Urbanska, A. M., Nagar, K., Westphalen, C. B., Quante, M., . . . Wang, T. C. (2017). Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling. Cancer Cell. https://doi.org/10.1016/j.ccell.2016.11.005
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