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Endothelial Neuropilin Disruption in Mice Causes DiGeorge Syndrome-Like Malformations via Mechanisms Distinct to Those Caused by Loss of Tbx1

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CCM3 Loss-Induced Lymphatic Defect Is Mediated by the Augmented VEGFR3-ERK1/2 Signaling

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Primary lymphedema and other lymphatic anomalies are associated with 22q11.2 deletion syndrome

Unolt, M., Barry, J. C., Digilio, M. C., Marino, B., Bassett, A. S., Oechslin, E. N., Low, D. W., Belasco, J. B., Kallish, S., Sullivan, K. E., et al. (2018) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2018.02.006 · Cited by 7 · see citing works

TBX1 Functions as a Tumor Activator in Prostate Cancer by Promoting Ribosome RNA Gene Transcription

Cui, J., Zhang, Y., Ren, X., Jin, L., & Zhang, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.616173 · Cited by 7 · see citing works

22q11 Deletion Syndrome

Fernandez, A., Meechan, D. W., Baker, J. L., Karpinski, B. A., LaMantia, A., & Maynard, T. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405945-0.00036-3 · Cited by 6 · see citing works

Network patterning, morphogenesis and growth in lymphatic vascular development

Grimm, L., & Hogan, B. M. (2020) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.10.007 · Cited by 6 · see citing works

TBX1 regulates myogenic differentiation by activating the TGFβ-Smad2/3 pathway in myoblasts

Cen, H., Luo, H., Luo, B., Pin, F., Zhang, Y., & Zhang, Y. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221112087 · Cited by 5 · see citing works

Tbx1 orchestrates an immune niche that safeguards a broken heart

Perrotta, S., & Carnevale, D. (2023) · Immunity · doi:10.1016/j.immuni.2023.09.008 · Cited by 2 · see citing works

Mesenteric Organ Lymphatics in Abdominal Inflammation

Huang, L., & Li, Y. (2023) · Progress in inflammation research · doi:10.1007/978-3-031-17774-3_4 · Cited by 2 · see citing works

Different Transcriptome Signatures of the Lymphatic and the Blood Vessels From Rat Mesentery Reveal Distinct Function Characteristics

Jing, Y., Zhai, J., Gao, M., Xu, X., Zhao, Z., & Zhao, Z. (2025) · Microcirculation · doi:10.1111/micc.70003 · Cited by 1 · see citing works

Molecular Mechanisms and Therapeutic Strategies Targeting Cardiac Lymphangiogenesis in Heart Failure

Chien, M.-H., Liu, D., Zheng, Z., Song, Z., Zheng, M., & Wang, W. (2025) · Cardiovascular Toxicology · doi:10.1007/s12012-025-10073-9 · Cited by 2 · see citing works

Aquaporin-1 sustains lymphangiogenic responses in hyperosmotic inflammatory microenvironments

Roçi, I., Kim, J., de Korodi, K., Wyss, T., Bernier‐Latmani, J., Arroz‐Madeira, S., González‐Loyola, A., Bovay, E., Grenningloh, N., Schoofs, H., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20250506 · Cited by 2 · see citing works

Endothelial Differentiation of Embryonic Stem Cells

Oettgen, P. (2011) · InTech eBooks · doi:10.5772/24517 · Cited by 1 · see citing works

Embryonic development in 22q11.2 deletion syndrome

Ivins, S. M., & Scambler, P. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-816047-3.00002-2 · Cited by 1 · see citing works

Sprouting angiogenesis in vascular and lymphatic development

Eichmann, A., & Li, J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822546-2.00006-x · Cited by 1 · see citing works

Aquaporin-1 sustains lymphangiogenic responses in inflammatory microenvironmentsPreprint

Roçi, I., Kim, J., de Korodi, K., Wyss, T., Bernier‐Latmani, J., Arroz‐Madeira, S., Bovay, E., Schoofs, H., Mäkinen, T., Noël, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.05.641652 · Cited by 1 · see citing works

Distinct topologically associated domains underlie regulatory logic in lymphatic endothelial cells contributing to proper cell differentiationPreprint

Panara, V., Arnold, H., Gloger, M., Skoczylas, R., Gutierrez, V. V., Johansson, A., Smialowska, A., & Koltowska, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.16.659849 · Cited by 1 · see citing works

22q11 Deletion Syndrome: A Role for Tbx1 in Pharynx and Cardiovascular Development

Calmont, A., & Scambler, P. J. (2010) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0006074.pub2

Literature Watch

Blei, F. (2010) · Lymphatic Research and Biology · doi:10.1089/lrb.2010.8402

Tbx1 regulatesVegfr3and is required for lymphatic vessel development

Chen, L., Mupo, A., Huynh, T., Cioffi, S., Woods, M., Jin, C., McKeehan, W. L., Thompson-Snipes, L., Baldini, A., & Illingworth, E. A. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem2075oia15

Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and rewires the microenvironment toward an immune-suppressive statePreprint

Tang, Y., Kwiatkowski, D. J., & Henske, E. P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.01.494055

Comment on “A left circumflex aorta with a displaced thoracic duct in a 94-year-old male cadaver: a case report with discussion on embryology”

Borthakur, D., George, F., & Dhingra, R. (2022) · Folia Morphologica · doi:10.5603/fm.a2022.0087

Lymphatics unload VEGFR3 in response to the alteration of VEGFR2-mediated transcriptional programsPreprint

Li, T., Cao, X., Fei, Z., Li, X., Ma, W., Zhang, X., Zhong, H., Xu, B., Chu, M., Jia, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.20.683599

Additional file 6 of High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification

Olbrecht, S., Busschaert, P., Qian, J., Vanderstichele, A., Loverix, L., Gorp, T. V., Van Nieuwenhuysen, E., Han, S., den Broeck, A. V., Coosemans, A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14936563

Additional file 3 of High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification

Olbrecht, S., Busschaert, P., Qian, J., Vanderstichele, A., Loverix, L., Gorp, T. V., Van Nieuwenhuysen, E., Han, S., den Broeck, A. V., Coosemans, A., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14936554

New frontiers of lymphangiogenesis

Natale, G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13979-6.00006-6

Playing CATCH-up: a case report of profound protein-losing enteropathy and gastrointestinal haemorrhage from intestinal lymphangiectasia in DiGeorge syndrome

Carrigan, L., Yap, J., & Cheung, M. M. H. (2026) · European Heart Journal - Case Reports · doi:10.1093/ehjcr/ytag257

Vegfr3 is required in the Tbx1 expression domain for cardiac outflow tract developmentPreprint

Martucciello, S., Bilio, M., Cioffi, S., Cavallaro, M., Baldini, A., & Illingworth, E. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.29.728669

Tumor‐Derived Exosomal piR ‐hsa‐28212 Promotes Lymphatic Metastasis in Breast Cancer

Wang, Y., Zhang, T., Kong, X., Tong, Y., Li, Y., Dong, X., Du, L., & Li, J. (2026) · Cancer Science · doi:10.1111/cas.70450

3D chromatin organisation contributes to the regulatory logic in differentiating lymphatic endothelium

Panara, V., Arnold, H., Gloger, M., Skoczylas, R., Gutierrez, V. P., Johansson, A., Smialowska, A., & Koltowska, K. (2026) · EMBO Reports · doi:10.1038/s44319-026-00895-1

Vegfr3 and Tbx1 Interact in Cardiac Morphogenesis

Martucciello, S., Bilio, M., Cioffi, S., Aurigemma, I., Cavallaro, M., Baldini, A., & Illingworth, E. A. (2026) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd13080399

Tbx1 alleviated hepatic encephalopathy by promoting meningeal lymphangiogenesis and drainage of senescent astrocytes via a CCL21-dependent manner

Luo, G., Wu, Z., Li, H., Qian, Y., Fan, Q., Zheng, L., Li, M., Lin, J., 吴光波, Zhao, J., et al. (2026) · Fundamental Research · doi:10.1016/j.fmre.2026.09.009

T-Box Genes and Developmental Anomalies

Douglas, N. C., Washkowitz, A. J., Naiche, L. A., & Papaioannou, V. E. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405945-0.00034-x

A dual role for Tbx1 in cardiac lymphangiogenesis through genetic interaction with Vegfr3

Martucciello, S., Turturo, M. G., Bilio, M., Cioffi, S., Chen, L., Baldini, A., & Illingworth, E. A. (2020) · The FASEB Journal · doi:10.1096/fj.201902202r · Cited by 20 · see citing works

Vascular Endothelial Growth Factor D Is Dispensable for Development of the Lymphatic System

Baldwin, M. E., Halford, M. M., Roufail, S., Williams, R. A., Hibbs, M. L., Grail, D., Kubo, H., Stacker, S. A., & Achen, M. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2441-2449.2005 · Cited by 289 · see citing works

Tbx1 regulates brain vascularization

Cioffi, S., Martucciello, S., Fulcoli, F. G., Bilio, M., Ferrentino, R., Nusco, E., & Illingworth, E. A. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt400 · Cited by 71 · see citing works

Abnormal embryonic lymphatic vessel development in Tie1 hypomorphic mice

Qu, X., Tompkins, K. L., Batts, L. E., Puri, M. C., & Baldwin, H. S. (2010) · Development · doi:10.1242/dev.043380 · Cited by 88 · see citing works

Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up‐regulation of Vegfr3 gene expression in lymphatic endothelial cells

Qin, T., Xu, G., Qi, J., Yang, G., Zhang, K., Liu, H., Xu, L., Xiang, R., Xiao, G., Cao, H., et al. (2015) · The Journal of Pathology · doi:10.1002/path.4577 · Cited by 25 · see citing works