The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway
Open accessAbstract
Invadopodia are invasive protrusions with proteolytic activity uniquely found in tumor cells. Cortactin phosphorylation is a key step during invadopodia maturation, regulating Nck1 binding and cofilin activity. The precise mechanism of cortactin-dependent cofilin regulation and the roles of this pathway in invadopodia maturation and cell invasion are not fully understood. We provide evidence that cortactin–cofilin binding is regulated by local pH changes at invadopodia that are mediated by the sodium–hydrogen exchanger NHE1. Furthermore, cortactin tyrosine phosphorylation mediates the recruitment of NHE1 to the invadopodium compartment, where it locally increases the pH to cause the release of cofilin from cortactin. We show that this mechanism involving cortactin phosphorylation, local pH increase, and cofilin activation regulates the dynamic cycles of invadopodium protrusion and retraction and is essential for cell invasion in 3D. Together, these findings identify a novel pH-dependent regulation of cell invasion.
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Citations
Cites
Precise Nanometer Localization Analysis for Individual Fluorescent Probes
Thompson, R. E., Larson, D. R., & Webb, W. W. (2002) · Biophysical Journal · doi:10.1016/s0006-3495(02)75618-x · Cited by 2,320
Self-citationActivation of Arp2/3 complex-mediated actin polymerization by cortactin
Uruno, T., Liu, J., Zhang, P., Fan, Y.-X., Egile, C., Li, R., Mueller, S. C., & Zhan, X. (2001) · Nature Cell Biology · doi:10.1038/35060051 · Cited by 568 · cited 1×
“…et al., 2007; Mader et al., 2011) promotes recruitment of the Nck1 adaptor protein, N-WASP, and cofilin (DesMarais et al., 2009; Oser et al., 2009), leading to an increased Arp2/3 complex–mediated actin polymerization at invadopodia (Uruno et al., 2001; Weaver et al., 2001; Oser et al., 2010).”
EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells
van Rheenen, J., Song, X., van Roosmalen, W., Cammer, M., Chen, X., DesMarais, V., Yip, S.-C., Backer, J. M., Eddy, R. J., & Condeelis, J. S. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706206 · Cited by 244
Self-citationTania, N., Prosk, E., Condeelis, J., & Edelstein-Keshet, L. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.02.036 · Cited by 32
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Cited by
pH sensing and regulation in cancer
Damaghi, M., Wojtkowiak, J. W., & Gillies, R. J. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00370 · Cited by 536
Directed cell invasion and migration during metastasis
Bravo-Cordero, J. J., Hodgson, L., & Condeelis, J. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.12.004 · Cited by 462
Self-citationFunctions of cofilin in cell locomotion and invasion
Bravo-Cordero, J. J., Magalhaes, M. A. O., Eddy, R. J., Hodgson, L., & Condeelis, J. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3609 · Cited by 461
Self-citationRole of Ion Channels and Transporters in Cell Migration
Schwab, A., Fabian, A., Hanley, P. J., & Stock, C. (2012) · Physiological Reviews · doi:10.1152/physrev.00018.2011 · Cited by 420
Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis
Leong, H. S., Robertson, A. E., Stoletov, K., Leith, S. J., Chin, C. A., Chien, A. E., Hague, M. N., Ablack, A., Carmine-Simmen, K., McPherson, V. A., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.050 · Cited by 400
Metadata
- Authors
- Magalhaes, M. A. O., Larson, D. R., Mader, C. C., Bravo-Cordero, J. J., Gil-Henn, H., Oser, M., Chen, X., Koleske, A. J., & Condeelis, J.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2011-11-21
- Volume
- 195
- Issue
- 5
- Pages
- 903-920
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2115732451
- Cited by
- 215
- References
- 4
- FWCI
- 10.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Magalhaes, M. A. O., Larson, D. R., Mader, C. C., Bravo-Cordero, J. J., Gil-Henn, H., Oser, M., Chen, X., Koleske, A. J., & Condeelis, J. (2011). Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway. Journal of Cell Biology. https://doi.org/10.1083/jcb.201103045
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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