The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Tension is required but not sufficient for focal adhesion maturation without a stress fiber template
Open accessAbstract
Focal adhesion composition and size are modulated in a myosin II–dependent maturation process that controls adhesion, migration, and matrix remodeling. As myosin II activity drives stress fiber assembly and enhanced tension at adhesions simultaneously, the extent to which adhesion maturation is driven by tension or altered actin architecture is unknown. We show that perturbations to formin and α-actinin 1 activity selectively inhibited stress fiber assembly at adhesions but retained a contractile lamella that generated large tension on adhesions. Despite relatively unperturbed adhesion dynamics and force transmission, impaired stress fiber assembly impeded focal adhesion compositional maturation and fibronectin remodeling. Finally, we show that compositional maturation of focal adhesions could occur even when myosin II–dependent cellular tension was reduced by 80%. We propose that stress fiber assembly at the adhesion site serves as a structural template that facilitates adhesion maturation over a wide range of tensions. This work identifies the essential role of lamellar actin architecture in adhesion maturation.
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Citations
Cites
Environmental sensing through focal adhesions
Geiger, B., Spatz, J. P., & Bershadsky, A. D. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2593 · Cited by 2,543
Local force and geometry sensing regulate cell functions
Vogel, V., & Sheetz, M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1890 · Cited by 2,328 · cited 1×
“Focal adhesions integrate mechanical, biochemical, and struc tural cues to provide dynamic links between the actin cytoskel eton and the surrounding ECM that are essential in guiding cell differentiation, proliferation, migration, and ECM remodeling (Vogel and Sheetz, 2006; Geiger et al., 2009; Parsons et al., 2010;…”
BackgroundEffects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
Yeung, T., Georges, P. C., Flanagan, L. A., Marg, B., Ortiz, M., Funaki, M., Zahir, N., Ming, W., Weaver, V., & Janmey, P. A. (2005) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20041 · Cited by 2,325
Forscher, P., & Smith, S. J. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.4.1505 · Cited by 854
Choi, C. K., Vicente-Manzanares, M., Zareno, J., Whitmore, L. A., Mogilner, A., & Horwitz, A. R. (2008) · Nature Cell Biology · doi:10.1038/ncb1763 · Cited by 797
Integrins and Extracellular Matrix in Mechanotransduction
Schwartz, M. A. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005066 · Cited by 662
Cited by
Integrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311
Case, L. B., & Waterman, C. M. (2015) · Nature Cell Biology · doi:10.1038/ncb3191 · Cited by 520
Focal adhesions, stress fibers and mechanical tension
Burridge, K., & Guilluy, C. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.10.029 · Cited by 409
α-Actinin-4 drives invasiveness by regulating myosin IIB expression and myosin IIA localization
Barai, A., Mukherjee, A., Das, A., Saxena, N., & Sen, S. (2021) · Journal of Cell Science · doi:10.1242/jcs.258581 · Cited by 23
Reduced cell-substrate adhesion formation promotes cell migration in Dictyostelium
Fierro Morales, J. C., A. Nguyen, T., Nepal, S., Redfearn, C., Gale, B. K., Titus, M. A., & Roh-Johnson, M. (2025) · Molecular Biology of the Cell · doi:10.1091/mbc.e25-05-0230 · Cited by 5
Metadata
- Authors
- Oakes, P. W., Beckham, Y., Stricker, J., & Gardel, M. L.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2012-01-30
- Volume
- 196
- Issue
- 3
- Pages
- 363-374
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2112924183
- Cited by
- 323
- References
- 6
- FWCI
- 16.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
