The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
The impact of the unfolded protein response on human disease
Open accessAbstract
A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and secretory activities in the cell. Alterations in ER homeostasis cause accumulation of misfolded/unfolded proteins in the ER. To maintain ER homeostasis, eukaryotic cells have evolved the unfolded protein response (UPR), an essential adaptive intracellular signaling pathway that responds to metabolic, oxidative stress, and inflammatory response pathways. The UPR has been implicated in a variety of diseases including metabolic disease, neurodegenerative disease, inflammatory disease, and cancer. Signaling components of the UPR are emerging as potential targets for intervention and treatment of human disease.
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THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
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Self-citationDynamic interaction of BiP and ER stress transducers in the unfolded-protein response
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Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
Han, J., Back, S. H., Hur, J., Lin, Y.-H., Gildersleeve, R., Shan, J., Yuan, C. L., Krokowski, D., Wang, S., Hatzoglou, M., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2738 · Cited by 1,691
Self-citationEndoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease
Cao, S. S., & Kaufman, R. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2014.5851 · Cited by 1,363
Self-citationTargeting the unfolded protein response in disease
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Metadata
- Authors
- Wang, S., & Kaufman, R. J.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2012-06-25
- Volume
- 197
- Issue
- 7
- Pages
- 857-867
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2056129497
- Cited by
- 984
- References
- 150
- FWCI
- 44.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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