The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish
Open accessAbstract
Tissue injury can lead to scar formation or tissue regeneration. How regenerative animals sense initial tissue injury and transform wound signals into regenerative growth is an unresolved question. Previously, we found that the Src family kinase (SFK) Lyn functions as a redox sensor in leukocytes that detects H2O2 at wounds in zebrafish larvae. In this paper, using zebrafish larval tail fins as a model, we find that wounding rapidly activated SFK and calcium signaling in epithelia. The immediate SFK and calcium signaling in epithelia was important for late epimorphic regeneration of amputated fins. Wound-induced activation of SFKs in epithelia was dependent on injury-generated H2O2. A SFK member, Fynb, was responsible for fin regeneration. This work provides a new link between early wound responses and late regeneration and suggests that redox, SFK, and calcium signaling are immediate “wound signals” that integrate early wound responses and late epimorphic regeneration.
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Cites
H 2 O 2 , a Necessary Evil for Cell Signaling
Rhee, S. G. (2006) · Science · doi:10.1126/science.1130481 · Cited by 2,160
Inflammatory cells during wound repair: the good, the bad and the ugly
Martin, P., & Leibovich, S. J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.09.002 · Cited by 1,340 · cited 1×
“Inflammation inhibits wound healing in mice under certain conditions (Martin, 1997; Martin and Leibovich, 2005), suggesting that inflammation could be upstream of regenerative defects in zebrafish.”
BackgroundYeatman, T. J. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1366 · Cited by 1,113
Dermal Wound Healing Is Subject to Redox Control
Roy, S., Khanna, S., Nallu, K., Hunt, T. K., & Sen, C. K. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2005.07.684 · Cited by 472
Cited by
Molecular Mechanisms of Plant Regeneration
Ikeuchi, M., Favero, D. S., Sakamoto, Y., Iwase, A., Coleman, D., Rymen, B., & Sugimoto, K. (2019) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050718-100434 · Cited by 521
Macrophages modulate adult zebrafish tail fin regeneration
Petrie, T. A., Strand, N. S., Tsung-Yang, C., Rabinowitz, J. S., & Moon, R. T. (2014) · Development · doi:10.1242/dev.098459 · Cited by 365
The role of reactive oxygen species and metabolism on cancer cells and their microenvironment
Costa, A., Scholer-Dahirel, A., & Mechta-Grigoriou, F. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.12.007 · Cited by 324
Gauron, C., Rampon, C., Bouzaffour, M., Ipendey, E., Teillon, J., Volovitch, M., & Vriz, S. (2013) · Scientific Reports · doi:10.1038/srep02084 · Cited by 291
The role of transcription-independent damage signals in the initiation of epithelial wound healing
Cordeiro, J. V., & Jacinto, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3541 · Cited by 273
Metadata
- Authors
- Yoo, S. K., Freisinger, C. M., LeBert, D. C., & Huttenlocher, A.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2012-10-08
- Volume
- 199
- Issue
- 2
- Pages
- 225-234
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2122019197
- Cited by
- 211
- References
- 4
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yoo, S. K., Freisinger, C. M., LeBert, D. C., & Huttenlocher, A. (2012). Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. Journal of Cell Biology. https://doi.org/10.1083/jcb.201203154
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