Macrophages modulate adult zebrafish tail fin regeneration
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Neutrophils and macrophages, as key mediators of inflammation, have defined functionally important roles in mammalian tissue repair. Although recent evidence suggests that similar cells exist in zebrafish and also migrate to sites of injury in larvae, whether these cells are functionally important for wound healing or regeneration in adult zebrafish is unknown. To begin to address these questions, we first tracked neutrophils (lyzC+, mpo+) and macrophages (mpeg1+) in adult zebrafish following amputation of the tail fin, and detailed a migratory timecourse that revealed conserved elements of the inflammatory cell response with mammals. Next, we used transgenic zebrafish in which we could selectively ablate macrophages, which allowed us to investigate whether macrophages were required for tail fin regeneration. We identified stage-dependent functional roles of macrophages in mediating fin tissue outgrowth and bony ray patterning, in part through modulating levels of blastema proliferation. Moreover, we also sought to detail molecular regulators of inflammation in adult zebrafish and identified Wnt/β-catenin as a signaling pathway that regulates the injury microenvironment, inflammatory cell migration and macrophage phenotype. These results provide a cellular and molecular link between components of the inflammation response and regeneration in adult zebrafish.
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In adult salamander limb and zebrafish fin regeneration, innate immune cell influx, particularly macrophages, preceding blastema formation is essential for regeneration.
“yet, recent studies in both adult salamander limb and zebrafish fin regeneration indicate that an innate immune cell influx, particularly of macrophages, preceding blastema formation is an essential component of regeneration (134, 135).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [135]
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Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · see citing works
Transient Regenerative Potential of the Neonatal Mouse Heart
Porrello, E. R., Mahmoud, A. I., Simpson, E., Hill, J. A., Richardson, J. A., Olson, E. N., & Sadek, H. A. (2011) · Science · doi:10.1126/science.1200708 · Cited by 2,545 · see citing works
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish
Niethammer, P., Grabher, C., Look, A. T., & Mitchison, T. J. (2009) · Nature · doi:10.1038/nature08119 · Cited by 1,541 · see citing works
Tian, E., Zhan, F., Walker, R. C., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,499 · see citing works
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
(1975) · PubMed Central · Cited by 1,437 · see citing works
Dickkopf-1 is a master regulator of joint remodeling
Diarra, D., Stolina, M., Polzer, K., Zwerina, J., Ominsky, M. S., Dwyer, D., Korb, A., Smolen, J. S., Hoffmann, M. H., Scheinecker, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1538 · Cited by 1,296 · see citing works
Differential Roles of Macrophages in Diverse Phases of Skin Repair
Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., & Eming, S. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903356 · Cited by 1,205 · cited 1× · see citing works
“Although mammalian macrophages serve unique, specific functions at distinct phases during tissue repair (Liu et al., 1999; Lucas et al., 2010), zebrafish macrophages seem to function differently at analogous stages after wounding.”
mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish
Ellett, F. E., Pase, L. B., Hayman, J. W., Andrianopoulos, A., & Lieschke, G. J. (2010) · Blood · doi:10.1182/blood-2010-10-314120 · Cited by 1,085 · see citing works
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S. E., & Cotsarelis, G. (2007) · Nature · doi:10.1038/nature05766 · Cited by 1,064 · see citing works
A transgenic zebrafish model of neutrophilic inflammation
Renshaw, S. A., Loynes, C. A., Trushell, D. M. I., Elworthy, S., Ingham, P. W., & Whyte, M. K. B. (2006) · Blood · doi:10.1182/blood-2006-05-024075 · Cited by 1,013 · see citing works
Ontogeny and behaviour of early macrophages in the zebrafish embryo
Herbomel, P., Thisse, B., & Thisse, C. (1999) · Development · doi:10.1242/dev.126.17.3735 · Cited by 799 · see citing works
Selective and Specific Macrophage Ablation Is Detrimental to Wound Healing in Mice
Mirza, R., DiPietro, L. A., & Koh, T. J. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090248 · Cited by 616 · see citing works
The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish
Hall, C. J., Flores, M. V., Storm, T., Crosier, K., & Crosier, P. S. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-42 · Cited by 582 · see citing works
Neutrophils cascading their way to inflammation
Sadik, C. D., Kim, N. D., & Luster, A. D. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.06.008 · Cited by 577 · see citing works
Obstacles and opportunities for understanding macrophage polarization
Murray, P. J., & Wynn, T. A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.0710409 · Cited by 565 · see citing works
Skin shedding and tissue regeneration in African spiny mice (Acomys)
Seifert, A. W., Kiama, S. G., Seifert, M. G., Goheen, J. R., Palmer, T. M., & Maden, M. (2012) · Nature · doi:10.1038/nature11499 · Cited by 556 · see citing works
Distinct Wnt signaling pathways have opposing roles in appendage regeneration
Stoick-Cooper, C. L., Weidinger, G., Riehle, K. J., Hubbert, C. C., Major, M. B., Fausto, N., & Moon, R. T. (2006) · Development · doi:10.1242/dev.001123 · Cited by 533 · see citing works
Self-citationResolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish
Mathias, J. R., Perrin, B. J., Liu, T.-X., Kanki, J. P., Look, A. T., & Anna Huttenlocher, A. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0506346 · Cited by 532 · see citing works
Accelerated wound closure in neutrophil-depleted mice
Dovi, J. V., He, L.-K., & DiPietro, L. A. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0802406 · Cited by 525 · see citing works
Urasaki, A., Morvan-Dubois, G., & Kawakami, K. (2006) · Genetics · doi:10.1534/genetics.106.060244 · Cited by 522 · see citing works
Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain
Kyritsis, N., Kızıl, Ç., Zocher, S., Kroehne, V., Kaslin, J., Freudenreich, D., Iltzsche, A., & Brand, M. (2012) · Science · doi:10.1126/science.1228773 · Cited by 512 · see citing works
Conditional targeted cell ablation in zebrafish: A new tool for regeneration studies
Curado, S., Anderson, R. M., Jungblut, B., Mumm, J. S., Schroeter, E. H., & Stainier, D. Y. R. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21100 · Cited by 509 · see citing works
Wound Macrophages as Key Regulators of Repair
Brancato, S. K., & Albina, J. E. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.08.003 · Cited by 508 · see citing works
Lieschke, G. J., Oates, A. C., Crowhurst, M. O., Ward, A. C., & Layton, J. E. (2001) · Blood · doi:10.1182/blood.v98.10.3087 · Cited by 489 · see citing works
Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium
Volkman, H. E., Pozos, T. C., Zheng, J., Davis, J. M., Rawls, J. F., & Ramakrishnan, L. (2009) · Science · doi:10.1126/science.1179663 · Cited by 445 · see citing works
Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish Fin
Knopf, F., Hammond, C., Chekuru, A., Kurth, T., Hans, S., Weber, C., Mahatma, G., Fisher, S., Brand, M., Schulte‐Merker, S., et al. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.04.014 · Cited by 374 · see citing works
Li, L., Yan, B., Shi, Y.-Q., Zhang, W.-Q., & Wen, Z.-L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.349126 · Cited by 353 · cited 3× · see citing works
“…cell movement to and from sites of injury is similar for adult zebrafish and mammals, where neutrophils are attracted to the wound first through ‘ homing ’ from the circulation, followed by circulation-based or resident macrophages (Sadik et al., 2011; Yoo and Huttenlocher, 2011; Li et al., 2012).”
A model 450 million years in the making: zebrafish and vertebrate immunity
Renshaw, S. A., & Trede, N. S. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.007138 · Cited by 350 · see citing works
Kintner, C. R., & Brockes, J. P. (1984) · Nature · doi:10.1038/308067a0 · Cited by 347 · see citing works
Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration
Lee, Y., Grill, S., Sanchez, A., Murphy‐Ryan, M., & Poss, K. D. (2005) · Development · doi:10.1242/dev.02101 · Cited by 340 · see citing works
Advances in signaling in vertebrate regeneration as a prelude to regenerative medicinePreprint
Stoick-Cooper, C. L., Moon, R. T., & Weidinger, G. (2007) · Genes & Development · doi:10.1101/gad.1540507 · Cited by 304 · see citing works
Self-citationWnt/β-catenin signaling regulates vertebrate limb regenerationPreprint
Kawakami, Y., Esteban, C. R., Raya, R. M., Kawakami, H., Martí, M., Dubova, I., & Belmonte, J. C. I. (2006) · Genes & Development · doi:10.1101/gad.1475106 · Cited by 300 · see citing works
Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes
Liu, Y., Cousin, J. M., Hughes, J., Van Damme, J., Seckl, J. R., Haslett, C., Dransfield, I., Savill, J., & Rossi, A. G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3639 · Cited by 299 · see citing works
Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases
Novoa, B., & Figueras, A. J. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0106-3_15 · Cited by 297 · see citing works
Morrison, J. I., Lööf, S., He, P., & Simon, A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200509011 · Cited by 246 · see citing works
Wnt Signaling and Injury RepairPreprint
Whyte, J. L., Smith, A. A., & Helms, J. A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008078 · Cited by 239 · see citing works
In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains
Moro, E., Özhan, G., Mongera, A., Beis, D., Wierzbicki, C., Young, R., Bournele, D., Domenichini, A., Valdivia, L. E., Lum, L., et al. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.03.023 · Cited by 237 · see citing works
Think Small: Zebrafish as a Model System of Human Pathology
Goldsmith, J. R., & Jobin, C. (2012) · BioMed Research International · doi:10.1155/2012/817341 · Cited by 229 · see citing works
Yoo, S. K., Freisinger, C. M., LeBert, D. C., & Anna Huttenlocher, A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201203154 · Cited by 211 · see citing works
Regeneration of Amputated Zebrafish Fin Rays from De Novo Osteoblasts
Singh, S. P., Holdway, J. E., & Poss, K. D. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.03.006 · Cited by 205 · see citing works
Redd, M. J., Kelly, G. P., Dunn, G., Way, M., & Martin, P. B. (2006) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.20133 · Cited by 193 · see citing works
Ren, S., Johnson, B. G., Kida, Y., Ip, C. S., Davidson, K. C., Lin, S., Kobayashi, A., Lang, R. A., Hadjantonakis, A., Moon, R. T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211179110 · Cited by 192 · see citing works
Self-citationEcheverri, K., Clarke, J. D. W., & Tanaka, E. M. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0312 · Cited by 190 · see citing works
Wehner, D., Cizelsky, W., Vasudevarao, M. D., Özhan, G., Haase, C., Kagermeier-Schenk, B., Röder, A., Dorsky, R. I., Moro, E., Argenton, F., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.12.036 · Cited by 184 · see citing works
Limb regeneration in higher vertebrates: Developing a roadmap
Han, M., Yang, X., Taylor, G. P., Burdsal, C. A., Anderson, R. A., & Muneoka, K. (2005) · The Anatomical Record Part B The New Anatomist · doi:10.1002/ar.b.20082 · Cited by 161 · see citing works
WISP-1 Is an Osteoblastic Regulator Expressed During Skeletal Development and Fracture Repair
French, D. M., Kaul, R. J., D’Souza, A. L., Crowley, C. W., Bao, M., Frantz, G. D., Filvaroff, E. H., & Desnoyers, L. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63348-2 · Cited by 152 · see citing works
Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway
Matzelle, M. M., Gallant, M. A., Condon, K. W., Walsh, N. C., Manning, C. A., Stein, G. S., Lian, J. B., Burr, D. B., & Gravallese, E. M. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33504 · Cited by 149 · see citing works
Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish
Yoo, S. K., & Anna Huttenlocher, A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1010567 · Cited by 149 · see citing works
Characterization of zebrafish larval inflammatory macrophages
Mathias, J. R., Dodd, M. E., Walters, K., Yoo, S. K., Ranheim, E. A., & Anna Huttenlocher, A. (2009) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2009.07.003 · Cited by 138 · see citing works
Live imaging of chronic inflammation caused by mutation of zebrafish Hai1
Mathias, J. R., Dodd, M. E., Walters, K., Rhodes, J., Kanki, J. P., Look, A. T., & Anna Huttenlocher, A. (2007) · Journal of Cell Science · doi:10.1242/jcs.009159 · Cited by 124 · see citing works
The Wnt Antagonist Dkk1 Regulates Intestinal Epithelial Homeostasis and Wound Repair
Koch, S., Nava, P., Addis, C. R., Kim, W., Denning, T. L., Li, L., Parkos, C. A., & Nusrat, A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.03.043 · Cited by 121 · see citing works
Colucci‐Guyon, E., Tinévez, J.-Y., Renshaw, S. A., & Herbomel, P. (2011) · Journal of Cell Science · doi:10.1242/jcs.082792 · Cited by 120 · see citing works
Pase, L., Layton, J. E., Wittmann, C., Ellett, F., Nowell, C. J., Reyes-Aldasoro, C. C., Varma, S., Rogers, K. L., Hall, C. J., Keightley, M. C., et al. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.060 · Cited by 118 · see citing works
Loynes, C. A., Martin, J. S., Robertson, A. L., Trushell, D. M. I., Ingham, P. W., Whyte, M. K. B., & Renshaw, S. A. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0409255 · Cited by 112 · see citing works
Macrophages and angiogenesis: a role for Wnt signaling
Newman, A. C., & Hughes, C. C. (2012) · Vascular Cell · doi:10.1186/2045-824x-4-13 · Cited by 87 · see citing works
Deng, Q., Harvie, E. A., & Anna Huttenlocher, A. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01738.x · Cited by 79 · see citing works
Resident Pleural Macrophages Are Key Orchestrators of Neutrophil Recruitment in Pleural Inflammation
Cailhier, J. F., Sawatzky, D. A., Kipari, T. M. J., Houlberg, K., Walbaum, D., Watson, S. J., Lang, R. A., Clay, S., Kluth, D., Savill, J., et al. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-538oc · Cited by 73 · see citing works
Thymosin β4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing
Evans, M. A., Smart, N., Dubé, K. N., Bollini, S., Clark, J., Evans, H. G., Taams, L. S., Richardson, R. J., Lévesque, M., Martin, P. B., et al. (2013) · Nature Communications · doi:10.1038/ncomms3081 · Cited by 72 · see citing works
Nachtrab, G. T., Kikuchi, K., Tornini, V. A., & Poss, K. D. (2013) · Development · doi:10.1242/dev.098798 · Cited by 69 · see citing works
Chen, C.-F., Chu, C.-Y., Chen, T.-H., Lee, S., Shen, C., & Hsiao, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020654 · Cited by 65 · see citing works
Neutrophil Depletion Blocks Early Collagen Degradation in Repairing Cholestatic Rat Livers
Harty, M. W., Muratore, C. S., Papa, E. F., Gart, M. S., Ramm, G. A., Gregory, S. H., & Tracy, T. F. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090527 · Cited by 62 · see citing works
Effects of inflammation on bone: an update
Baker-LePain, J. C., Nakamura, M. C., & Lane, N. E. (2011) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e3283474dbe · Cited by 60 · see citing works
Rieger, A. M., Konowalchuk, J. D., Grayfer, L., Katzenback, B. A., Havixbeck, J. J., Kiemele, M. D., Belosevic, M., & Barreda, D. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047070 · Cited by 57 · see citing works
Martin, P. B., & Feng, Y. (2009) · Nature · doi:10.1038/459921a · Cited by 44 · see citing works
The Role of Neutrophils in Corneal Wound Healing in HO-2 Null Mice
Marrazzo, G., Bellner, L., Halilovic, A., Volti, G. L., Drago, F., Dunn, M. W., & Schwartzman, M. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021180 · Cited by 38 · see citing works
Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish fad24
Walters, K., Dodd, M. E., Mathias, J. R., Gallagher, A. J., Bennin, D. A., Rhodes, J., Kanki, J. P., Look, A. T., Grinblat, Y., & Anna Huttenlocher, A. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21821 · Cited by 31 · see citing works
Sergeev, P., Streit, A., Heller, A., & Steinmann‐Zwicky, M. (2001) · Developmental Dynamics · doi:10.1002/1097-0177(2000)9999:9999 · Cited by 23 · see citing works
Wnts heal by restraining angiogenesis
Kitajewski, J. (2013) · Blood · doi:10.1182/blood-2013-01-479063 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 70 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562 · see citing works
Inflammation and metabolism in tissue repair and regeneration
Eming, S. A., Wynn, T. A., & Martin, P. (2017) · Science · doi:10.1126/science.aam7928 · Cited by 1,369 · see citing works
Promoting tissue regeneration by modulating the immune system
Julier, Z., Park, A. J., Briquez, P. S., & Martino, M. M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.056 · Cited by 766 · see citing works
Physiology and diseases of tissue-resident macrophages
Lazarov, T., Juarez-Carreño, S., Cox, N., & Geissmann, F. (2023) · Nature · doi:10.1038/s41586-023-06002-x · Cited by 540 · see citing works
Simões, F. C., Cahill, T. J., Kenyon, A., Gavriouchkina, D., Vieira, J. M., Sun, X., Pezzolla, D., Ravaud, C., Masmanian, E., Weinberger, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14263-2 · Cited by 394 · see citing works
Recurrent turnover of senescent cells during regeneration of a complex structure
Yun, M. H., Davaapil, H., & Brockes, J. P. (2015) · eLife · doi:10.7554/elife.05505 · Cited by 385 · see citing works
Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration
Li, J., Tan, J. L., Martino, M. M., & Lui, K. O. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00585 · Cited by 347 · see citing works
Tissue Stem Cells: Architects of Their Niches
Fuchs, E., & Blau, H. M. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.09.011 · Cited by 332 · see citing works
Macrophages: Their Emerging Roles in Bone
Sinder, B. P., Pettit, A. R., & McCauley, L. K. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2735 · Cited by 301 · see citing works
Identification of polarized macrophage subsets in zebrafish
Chi, M. N., Laplace-Builhe, B., Trávníčková, J., Luz‐Crawford, P., Téjédor, G., Phan, Q. T., Duroux-Richard, I., Levraud, J., Kissa, K., Lutfalla, G., et al. (2015) · eLife · doi:10.7554/elife.07288 · Cited by 295 · see citing works
Nerve Dependence: From Regeneration to Cancer
Boilly, B., Faulkner, S., Jobling, P., & Hondermarck, H. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.005 · Cited by 295 · see citing works
The wound inflammatory response exacerbates growth of pre‐neoplastic cells and progression to cancer
Antonio, N., Bønnelykke‐Behrndtz, M. L., Ward, L., Collin, J. D., Christensen, I. J., Steiniche, T., Schmidt, H., Feng, Y., & Martin, P. B. (2015) · The EMBO Journal · doi:10.15252/embj.201490147 · Cited by 282 · see citing works
Tissue repair and regeneration with endogenous stem cells
Xia, H., Li, X., Gao, W.-W., Fu, X., Fang, R. H., Zhang, L.-F., & Zhang, K. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0027-6 · Cited by 235 · see citing works
Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs
Hui, S. P., Sheng, D. Z., Sugimoto, K., González-Rajal, Á., Nakagawa, S., Hesselson, D., & Kikuchi, K. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.11.010 · Cited by 269 · see citing works
Two to Tango: Dialog between Immunity and Stem Cells in Health and Disease
Naik, S., Larsen, S. B., Cowley, C. J., & Fuchs, E. V. (2018) · Cell · doi:10.1016/j.cell.2018.08.071 · Cited by 249 · see citing works
The Macrophage in Cardiac Homeostasis and Disease
Lavine, K. J., Pinto, A. R., Epelman, S., Kopecky, B. J., Clemente-Casares, X., Godwin, J., Rosenthal, N., & Kovacic, J. C. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2149 · Cited by 234 · see citing works
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Copper toxicology, oxidative stress and inflammation using zebrafish as experimental model
Pereira, T. C. B., Campos, M. M., & Bogo, M. R. (2016) · Journal of Applied Toxicology · doi:10.1002/jat.3303 · Cited by 230 · see citing works
Macrophages and fibroblasts during inflammation and tissue repair in models of organ regeneration
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Changes in Regenerative Capacity through Lifespan
Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216 · see citing works
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Nguyen-Chi, M., Laplace-Builhé, B., Travnickova, J., Luz-Crawford, P., Tejedor, G., Lutfalla, G., Kissa, K., Jorgensen, C., & Djouad, F. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.374 · Cited by 190 · see citing works
Macrophages are necessary for epimorphic regeneration in African spiny mice
Simkin, J., Gawriluk, T. R., Gensel, J. C., & Seifert, A. W. (2017) · eLife · doi:10.7554/elife.24623 · Cited by 190 · see citing works
de Oliveira, S., Houseright, R. A., Graves, A. L., Golenberg, N., Korte, B. G., Miskolci, V., & Anna Huttenlocher, A. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.11.034 · Cited by 189 · see citing works
Effects of inflammation on stem cells: together they strive?
Kızıl, Ç., Kyritsis, N., & Brand, M. (2015) · EMBO Reports · doi:10.15252/embr.201439702 · Cited by 180 · see citing works
White, D. T., Sengupta, S., Saxena, M. T., Xu, Q., Hanes, J. S., Ding, D., Ji, H., & Mumm, J. S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617721114 · Cited by 165 · see citing works
Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs
Xie, Y., Meijer, A. H., & Schaaf, M. J. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.620984 · Cited by 164 · see citing works
Hasegawa, T., Hall, C. J., Crosier, P. S., Abe, G., Kawakami, K., Kudō, A., & Kawakami, A. (2017) · eLife · doi:10.7554/elife.22716 · Cited by 151 · see citing works
Matrix metalloproteinase 9 modulates collagen matrices and wound repair
LeBert, D. C., Squirrell, J. M., Rindy, J., Broadbridge, E., Lui, Y., Zakrzewska, A., Eliceiri, K. W., Meijer, A. H., & Anna Huttenlocher, A. (2015) · Development · doi:10.1242/dev.121160 · Cited by 148 · see citing works
Inflammation and immunity in organ regeneration
Mescher, A. L., Neff, A. W., & King, M. W. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.02.015 · Cited by 145 · see citing works
Epithelial cells: liaisons of immunity
Larsen, S. B., Cowley, C. J., & Fuchs, E. V. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.11.004 · Cited by 142 · see citing works
The blastema and epimorphic regeneration in mammals
Seifert, A. W., & Muneoka, K. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.08.007 · Cited by 139 · see citing works
Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair
Keane, T. J., Horejs, C., & Stevens, M. M. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.02.002 · Cited by 142 · see citing works
SIRT1 regulates macrophage self‐renewal
Imperatore, F., Maurizio, J., Aguilar, S. V., Busch, C. J., Favret, J., Kowenz‐Leutz, E., Cathou, W., Gentek, R., Perrin, P., Leutz, A., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201695737 · Cited by 124 · see citing works
Generic wound signals initiate regeneration in missing-tissue contexts
Owlarn, S., Klenner, F., Schmidt, D., Rabert, F., Tomasso, A., Reuter, H., Mulaw, M. A., Moritz, S., Gentile, L., Weidinger, G., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02338-x · Cited by 123 · see citing works
The role of macrophages during acute kidney injury: destruction and repair
Han, H. I., Skvarca, L. B., Espiritu, E. B., Davidson, A. J., & Hukriede, N. A. (2018) · Pediatric Nephrology · doi:10.1007/s00467-017-3883-1 · Cited by 121 · see citing works
Chasing the recipe for a pro-regenerative immune system
Godwin, J. W., Pinto, A., & Rosenthal, N. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.08.008 · Cited by 107 · see citing works
Myocardial NF-κB activation is essential for zebrafish heart regeneration
Karra, R., Knecht, A. K., Kikuchi, K., & Poss, K. D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511209112 · Cited by 113 · see citing works
Inflammation in tissue engineering: The Janus between engraftment and rejection
Crupi, A., Costa, A., Tarnok, A., Melzer, S., & Teodori, L. (2015) · European Journal of Immunology · doi:10.1002/eji.201545818 · Cited by 108 · see citing works
Rabinowitz, J. S., Robitaille, A. M., Wang, Y., Ray, C. A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J. D., & Moon, R. T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620755114 · Cited by 106 · see citing works
Self-citationA macrophage relay for long distance signaling during post-embryonic tissue remodeling
Eom, D., & Parichy, D. M. (2017) · Science · doi:10.1126/science.aal2745 · Cited by 100 · see citing works
Morales, R. A., & Allende, M. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00253 · Cited by 99 · see citing works
Senescent cells and macrophages: key players for regeneration?
Elder, S. S., & Emmerson, E. (2020) · Open Biology · doi:10.1098/rsob.200309 · Cited by 102 · see citing works
Mitchell, D. M., Lovel, A. G., & Stenkamp, D. L. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1185-6 · Cited by 126 · see citing works
Macrophages are required to coordinate mouse digit tip regeneration
Simkin, J., Sammarco, M. C., Marrero, L., Dawson, L. A., Yan, M.-Q., Tucker, C., Cammack, A., & Muneoka, K. (2017) · Development · doi:10.1242/dev.150086 · Cited by 89 · see citing works
Poss, K. D., & Tanaka, E. M. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.07.007 · Cited by 94 · see citing works
Conedera, F. M., Pousa, A. M. Q., Mercader, N., Tschopp, M., & Enzmann, V. (2019) · Glia · doi:10.1002/glia.23601 · Cited by 94 · see citing works
Determining macrophage versus neutrophil contributions to innate immunity using larval zebrafish
Rosowski, E. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.041889 · Cited by 82 · see citing works
Zebrafish: An Emerging Model for Orthopedic Research
Busse, B., Galloway, J. L., Gray, R. S., Harris, M. P., & Kwon, R. Y. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24539 · Cited by 91 · see citing works
Review of inflammation in fish and value of the zebrafish model
Campos‐Sánchez, J. C., & Esteban, M. Á. (2020) · Journal of Fish Diseases · doi:10.1111/jfd.13310 · Cited by 92 · see citing works
Sharrock, A. V., Mulligan, T. S., Hall, K. R., Williams, E. M., White, D. T., Zhang, L., Emmerich, K., Matthews, F., Nimmagadda, S., Washington, S., et al. (2022) · Nature Methods · doi:10.1038/s41592-021-01364-4 · Cited by 84 · see citing works
Sanz-Morejón, A., García‐Redondo, A. B., Reuter, H., Marques, I. J., Bates, T. J. D., Galardi‐Castilla, M., Große, A., Manig, S., Langa, X., Ernst, A., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.091 · Cited by 81 · see citing works
Pei, W., Tanaka, K., Huang, S. C., Xu, L., Liu, B., Sinclair, J. W., Idol, J., Varshney, G. K., Huang, H., Lin, S., et al. (2016) · npj Regenerative Medicine · doi:10.1038/npjregenmed.2016.13 · Cited by 81 · see citing works
Inflammation induces zebrafish regeneration
Iribarne, M. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.306059 · Cited by 73 · see citing works
Host–Parasite Interactions Promote Disease Tolerance to Intestinal Helminth Infection
King, I. L., & Li, Y.-H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02128 · Cited by 58 · see citing works
Epithelial Cells and Inflammation in Pulmonary Wound Repair
Lucchini, A. C., Gachanja, N. N., Rossi, A., Dorward, D., & Lucas, C. D. (2021) · Cells · doi:10.3390/cells10020339 · Cited by 70 · see citing works
Gómez, C. M. A., Sabin, K., & Echeverri, K. (2020) · Developmental Dynamics · doi:10.1002/dvdy.178 · Cited by 66 · see citing works
Regeneration of the central nervous system-principles from brain regeneration in adult zebrafish
Zambusi, A., & Ninkovic, J. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i1.8 · Cited by 72 · see citing works
Anti-Inflammatory Effects of Cajaninstilbene Acid and Its Derivatives
Huang, M., Lin, J., Lu, K., Xu, H., Geng, Z.-Z., Sun, P., & Chen, W. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b00227 · Cited by 73 · see citing works
Cellular diversity of the regenerating caudal fin
Hou, Y., Lee, H. J., Chen, Y., Ge, J., Osman, F. O. I., McAdow, A. R., Mokalled, M. H., Johnson, S. L., Zhao, G., & Wang, T. (2020) · Science Advances · doi:10.1126/sciadv.aba2084 · Cited by 72 · see citing works
Macrophages: The Potent Immunoregulatory Innate Immune Cells
Kumar, V. (2019) · Macrophage Activation - Biology and Disease · doi:10.5772/intechopen.88013 · Cited by 63 · see citing works
Insights into sensory hair cell regeneration from the zebrafish lateral line
Kniss, J. S., Jiang, L., & Piotrowski, T. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.05.012 · Cited by 70 · see citing works
Using biomaterials to rewire the process of wound repair
Stejskalová, A., & Almquist, B. D. (2017) · Biomaterials Science · doi:10.1039/c7bm00295e · Cited by 70 · see citing works
Cellular senescence: a view throughout organismal life
von Kobbe, C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2879-8 · Cited by 69 · see citing works
NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration
Mishra, R., Sehring, I. M., Cederlund, M. L., Mulaw, M. A., & Weidinger, G. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.11.016 · Cited by 70 · see citing works
Yamaguchi, T., Takizawa, F., Fischer, U., & Dijkstra, J. M. (2015) · Biology · doi:10.3390/biology4040814 · Cited by 66 · see citing works
Digit Tip Regeneration: Merging Regeneration Biology with Regenerative Medicine
Dolan, C. P., Dawson, L., & Muneoka, K. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.17-0236 · Cited by 67 · see citing works
Macrophages are necessary for skin regeneration during tissue expansion
Ding, J., Lei, L., Liu, S.-Q., Zhang, Y., Yu, Z., Su, Y.-J., & Ma, X.-J. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1780-z · Cited by 62 · see citing works
Animal regeneration in the era of transcriptomics
Bideau, L., Kerner, P., Hui, J. H. L., Vervoort, M., & Gazave, E. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03760-7 · Cited by 64 · see citing works
Psarras, S., Beis, D., Nikouli, S., Tsikitis, M., & Capetanaki, Y. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00032 · Cited by 62 · see citing works
Hartig, E. I., Zhu, S., King, B. L., & Coffman, J. A. (2016) · Biology Open · doi:10.1242/bio.020065 · Cited by 62 · see citing works
Dynamic microRNA-101a and Fosab expression controls zebrafish heart regeneration
Beauchemin, M., Smith, A., & Yin, V. P. (2015) · Development · doi:10.1242/dev.126649 · Cited by 61 · see citing works
Hoodless, L. J., Lucas, C. D., Duffin, R., Denvir, M. A., Haslett, C., Tucker, C. S., & Rossi, A. G. (2016) · Scientific Reports · doi:10.1038/srep36980 · Cited by 61 · see citing works
Bouten, C. V. C., Smits, A. I. P. M., & Baaijens, F. F. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00054 · Cited by 61 · see citing works
Lin, X., Zhou, Q., Zhao, C., Lin, G., Xu, J., & Wen, Z. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.03.028 · Cited by 61 · see citing works
Regenerative Biology of Tendon: Mechanisms for Renewal and Repair
Dyment, N. A., & Galloway, J. L. (2015) · Current Molecular Biology Reports · doi:10.1007/s40610-015-0021-3 · Cited by 59 · see citing works
Redirecting cardiac growth mechanisms for therapeutic regeneration
Karra, R., & Poss, K. D. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89786 · Cited by 59 · see citing works
The Evolving Roles of Cardiac Macrophages in Homeostasis, Regeneration, and Repair
Alvarez‐Argote, S., & O'Meara, C. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157923 · Cited by 56 · see citing works
Macrophages enhance Vegfa-driven angiogenesis in an embryonic zebrafish tumour xenograft model
Britto, D. D., Wyroba, B., Chen, W., Lockwood, R. A., Tran, K. B., Shepherd, P. R., Hall, C. J., Crosier, K. E., Crosier, P. S., & Astin, J. W. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.035998 · Cited by 56 · see citing works
Immune cell dynamics in the CNS: Learning from the zebrafish
Oosterhof, N., Boddeke, E., & van Ham, T. J. (2014) · Glia · doi:10.1002/glia.22780 · Cited by 53 · see citing works
de Kort, B. J., Koch, S. E., Wissing, T. B., Krebber, M. M., Bouten, C. V. C., & Smits, A. I. P. M. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113960 · Cited by 58 · see citing works
Macrophages in Zebrafish Models of Liver Diseases
Shwartz, A., Goessling, W., & Yin, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02840 · Cited by 53 · see citing works
Toxicity of silver nanoparticles on wound healing: A case study of zebrafish fin regeneration model
Pang, S., Gao, Y., Wang, F., Wang, Y., Cao, M., Zhang, W., Liang, Y., Song, M., & Jiang, G. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137178 · Cited by 52 · see citing works
Ogle, M. E., Krieger, J. R., Tellier, L. E., McFaline‐Figueroa, J., Temenoff, J. S., & Botchwey, E. A. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00706 · Cited by 52 · see citing works
Blastemal progenitors modulate immune signaling during early limb regeneration
Tsai, S. L., Baselga‐Garriga, C., & Melton, D. A. (2019) · Development · doi:10.1242/dev.169128 · Cited by 52 · see citing works
Inflammation Shapes Stem Cells and Stemness during Infection and Beyond
Michael, S., Achilleos, C., Panayiotou, T., & Strati, K. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00118 · Cited by 51 · see citing works
Wound‐induced cell proliferation during animal regeneration
Ricci, L., & Srivastava, M. (2018) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.321 · Cited by 49 · see citing works
Kaveh, A., Bruton, F. A., Buckley, C., Oremek, M. E. M., Tucker, C. S., Mullins, J. J., Taylor, J. M., Rossi, A. G., & Denvir, M. A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.579943 · Cited by 48 · see citing works
Denans, N., Tran, N. T. T., Swall, M. E., Diaz, D. C., Blanck, J. F., & Piotrowski, T. (2022) · Nature Communications · doi:10.1038/s41467-022-33015-3 · Cited by 48 · see citing works
Smits, A. I. P. M., & Bouten, C. V. C. (2018) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2018.02.006 · Cited by 48 · see citing works
Cardeira-da-Silva, J., Gavaia, P. J., Fernández, I., Cengiz, I. F., Moreira‐Silva, J., Oliveira, J. M., Reis, R. L., Cancela, M. L., & Laizé, V. (2016) · Scientific Reports · doi:10.1038/srep39191 · Cited by 47 · see citing works
Chen, H., Jolly, C., Bublys, K., Marcu, D., & Immler, S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1918205117 · Cited by 47 · see citing works
Role of Macrophages and Microglia in Zebrafish Regeneration
Var, S. R., & Byrd-Jacobs, C. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134768 · Cited by 48 · see citing works
Appendage Regeneration in Vertebrates: What Makes This Possible?
Daponte, V., Tylżanowski, P., & Forlino, A. (2021) · Cells · doi:10.3390/cells10020242 · Cited by 47 · see citing works
Sipka, T., Peroceschi, R., Hassan-Abdi, R., Groß, M., Ellett, F., Begon-Pescia, C., Gonzalez, C., Lutfalla, G., & Nguyen-Chi, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.636585 · Cited by 35 · see citing works
Al‐Darraji, A., Haydar, D., Chelvarajan, L., Tripathi, H., Levitan, B. M., Gao, E., Venditto, V. J., Gensel, J. C., Feola, D. J., & Abdel‐Latif, A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200474 · Cited by 45 · see citing works
Gawriluk, T. R., Simkin, J., Hacker, C. K., Kimani, J., Kiama, S., Ezenwa, V., & Seifert, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01695 · Cited by 35 · see citing works
Calcineurin controls proximodistal blastema polarity in zebrafish fin regeneration
Cao, Z., Meng, Y., Gong, F., Xu, Z., Liu, F., Fang, M., Zou, L., Liao, X., Wang, X., Luo, L., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009539118 · Cited by 46 · see citing works
The immune response is a critical regulator of zebrafish retinal pigment epithelium regeneration
Leach, L. L., Hanovice, N. J., George, S. M., Gabriel, A. E., & Gross, J. M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017198118 · Cited by 46 · see citing works
Iribarne, M., & Hyde, D. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.892271 · Cited by 45 · see citing works
- Authors
- Petrie, T. A., Strand, N. S., Tsung-Yang, C., Rabinowitz, J. S., & Moon, R. T.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Washington (US)
- Corresponding author
- Petrie, Timothy A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2014-07-01
- Volume
- 141
- Issue
- 13
- Pages
- 2581-2591
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- PMC
- PMC4067955
- OpenAlex
- W2152663152
- Cited by
- 365
- References
- 70
- Citations by year
- 2026: 26 · 2025: 20 · 2024: 37 · 2023: 23 · 2022: 40 · 2021: 46 · 2020: 38 · 2019: 36 · 2018: 30 · 2017: 24 · 2016: 23 · 2015: 17 · 2014: 4
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Development (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institute of General Medical Sciences (GM081619, GM00727, T32GM007270, P01GM081619)
- National Institute of Allergy and Infectious Diseases (AI54503, AI036396, R01AI036396, R37AI054503, R01AI054503)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- macrophages, tail fin regeneration, zebrafish, neutrophils, inflammation, wound healing, macrophage depletion, Wnt/β-catenin signaling, inflammatory cell migration, macrophage phenotype, tissue repair
- MeSH terms
- Amputation, Surgical, Animals, Cell Movement, Flow Cytometry, Immunohistochemistry, Inflammation, Macrophages, Microscopy, Fluorescence, Morphogenesis, Neutrophils, Regeneration, Tail, Zebrafish, DNA Primers, Animals, Genetically Modified, Real-Time Polymerase Chain Reaction
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