The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed
Open accessAbstract
A major issue in regenerative medicine is the role of injury in promoting cell plasticity. Here we explore the function of reactive oxygen species (ROS) induced through lesions in adult zebrafish. We show that ROS production, following adult fin amputation, is tightly regulated in time and space for at least 24 hours, whereas ROS production remains transient (2 hours) in mere wound healing. In regenerative tissue, ROS signaling triggers two distinct parallel pathways: one pathway is responsible for apoptosis, and the other pathway is responsible for JNK activation. Both events are involved in the compensatory proliferation of stump epidermal cells and are necessary for the progression of regeneration. Both events impact the Wnt, SDF1 and IGF pathways, while apoptosis only impacts progenitor marker expression. These results implicate oxidative stress in regeneration and provide new insights into the differences between healing and regeneration.
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Cites
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Cells keep a memory of their tissue origin during axolotl limb regeneration
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Cited by
Hervera, A., De Virgiliis, F., Palmisano, I., Zhou, L., Tantardini, E., Kong, G., Hutson, T., Danzi, M. C., Perry, R. B.-T., Santos, C. X. C., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0039-x · Cited by 331
JNK signaling in cancer cell survival
Wu, Q., Wu, W., Fu, B., Shi, L., Wang, X., & Kuca, K. (2019) · Medicinal Research Reviews · doi:10.1002/med.21574 · Cited by 322
Changes in Regenerative Capacity through Lifespan
Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216
A matter of life and death: stem cell survival in tissue regeneration and tumour formation
Soteriou, D., & Fuchs, Y. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.122 · Cited by 87
Metformin: prevention of genomic instability and cancer: a review
Najafi, M., Cheki, M., Rezapoor, S., Geraily, G., Motevaseli, E., Carnovale, C., Clementi, E., & Shirazi, A. (2018) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2018.01.007 · Cited by 75
Metadata
- Authors
- Gauron, C., Rampon, C., Bouzaffour, M., Ipendey, E., Teillon, J., Volovitch, M., & Vriz, S.
- Venue
- Scientific Reports
- Published
- 2013-06-27
- Volume
- 3
- Issue
- 1
- Pages
- 2084-2084
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2027827026
- Cited by
- 291
- References
- 52
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gauron, C., Rampon, C., Bouzaffour, M., Ipendey, E., Teillon, J., Volovitch, M., & Vriz, S. (2013). Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed. Scientific Reports. https://doi.org/10.1038/srep02084
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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