The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Phase transitions and size scaling of membrane-less organelles
Open accessAbstract
The coordinated growth of cells and their organelles is a fundamental and poorly understood problem, with implications for processes ranging from embryonic development to oncogenesis. Recent experiments have shed light on the cell size–dependent assembly of membrane-less cytoplasmic and nucleoplasmic structures, including ribonucleoprotein (RNP) granules and other intracellular bodies. Many of these structures behave as condensed liquid-like phases of the cytoplasm/nucleoplasm. The phase transitions that appear to govern their assembly exhibit an intrinsic dependence on cell size, and may explain the size scaling reported for a number of structures. This size scaling could, in turn, play a role in cell growth and size control.
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Kato, M., Han, T. W., Xie, S., Shi, K., Du, X., Wu, L. C., Mirzaei, H., Goldsmith, E. J., Longgood, J., Pei, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.017 · Cited by 2,012
Reversible compartmentalization of de novo purine biosynthetic complexes in living cells
An, S., Kumar, R., Sheets, E. D., & Benkovic, S. J. (2008) · Science · doi:10.1126/science.1152241 · Cited by 585 · cited 2×
“Liquid droplet phases are commonly seen in concentrated protein solutions in vitro (Asherie, 2004), and their assembly represents the same physics underlying the condensation of dew droplets from concentrated water vapor.”
Pederson, T. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000638 · Cited by 455
Cited by
Liquid-Liquid Phase Separation in Biology
Hyman, A. A., Weber, C. A., & Jülicher, F. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013325 · Cited by 3,155
Coactivator condensation at super-enhancers links phase separation and gene control
Sabari, B. R., Dall’Agnese, A., Boija, A., Klein, I. A., Coffey, E. L., Shrinivas, K., Abraham, B. J., Hannett, N. M., Zamudio, A. V., Manteiga, J. C., et al. (2018) · Science · doi:10.1126/science.aar3958 · Cited by 2,595
Distinct stages in stress granule assembly and disassembly
Wheeler, J. R., Matheny, T., Jain, S., Abrisch, R., & Parker, R. (2016) · eLife · doi:10.7554/elife.18413 · Cited by 804
Uversky, V. N. (2017) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2016.10.015 · Cited by 707
Zeng, M., Shang, Y., Araki, Y., Guo, T., Huganir, R. L., & Zhang, M. (2016) · Cell · doi:10.1016/j.cell.2016.07.008 · Cited by 608
Metadata
- Authors
- Brangwynne, C. P.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2013-12-23
- Volume
- 203
- Issue
- 6
- Pages
- 875-881
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1985681646
- Cited by
- 429
- References
- 3
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Brangwynne, C. P. (2013). Phase transitions and size scaling of membrane-less organelles. Journal of Cell Biology. https://doi.org/10.1083/jcb.201308087
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