The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Distinct stages in stress granule assembly and disassembly
Open accessAbstract
Stress granules are non-membrane bound RNA-protein (RNP) assemblies that form when translation initiation is limited and contain a biphasic structure with stable core structures surrounded by a less concentrated shell. The order of assembly and disassembly of these two structures remains unknown. Time course analysis of granule assembly suggests that core formation is an early event in granule assembly. Stress granule disassembly is also a stepwise process with shell dissipation followed by core clearance. Perturbations that alter liquid-liquid phase separations (LLPS) driven by intrinsically disordered protein regions (IDR) of RNA binding proteins in vitro have the opposite effect on stress granule assembly in vivo. Taken together, these observations argue that stress granules assemble through a multistep process initiated by stable assembly of untranslated mRNPs into core structures, which could provide sufficient high local concentrations to allow for a localized LLPS driven by IDRs on RNA binding proteins.
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1 retracted
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Cited by
A Phase Separation Model for Transcriptional Control
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Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization
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Liao, Y.-C., Fernandopulle, M. S., Wang, G., Choi, H., Hao, L., Drerup, C. M., Patel, R., Qamar, S., Nixon-Abell, J., Shen, Y., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.050 · Cited by 550
Metadata
- Authors
- Wheeler, J. R., Matheny, T., Jain, S., Abrisch, R., & Parker, R.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2016-09-07
- Volume
- 5
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2514004327
- Cited by
- 804
- References
- 49
- FWCI
- 23.47
- Type
- journal article
- Language
- en
- Open access
- gold
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