The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin
Open accessAbstract
The Parkinson’s disease factors PINK1 and parkin are strongly implicated in stress-induced mitophagy in vitro, but little is known about their impact on basal mitophagy in vivo. We generated transgenic Drosophila melanogaster expressing fluorescent mitophagy reporters to evaluate the impact of Pink1/parkin mutations on basal mitophagy under physiological conditions. We find that mitophagy is readily detectable and abundant in many tissues, including Parkinson’s disease–relevant dopaminergic neurons. However, we did not detect mitolysosomes in flight muscle. Surprisingly, in Pink1 or parkin null flies, we did not observe any substantial impact on basal mitophagy. Because these flies exhibit locomotor defects and dopaminergic neuron loss, our findings raise questions about current assumptions of the pathogenic mechanism associated with the PINK1/parkin pathway. Our findings provide evidence that Pink1 and parkin are not essential for bulk basal mitophagy in Drosophila. They also emphasize that mechanisms underpinning basal mitophagy remain largely obscure.
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Cites
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
Pickrell, A. M., & Youle, R. J. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.007 · Cited by 2,310
Mitochondrial Complex I Deficiency in Parkinson's Disease
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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
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MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE
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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
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Self-citationPARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
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Self-citationAutophagy in major human diseases
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Mitochondrial Dynamics and Its Involvement in Disease
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Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242
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Metadata
- Authors
- Lee, J. J., Sanchez-Martinez, A., Zarate, A. M., Benincá, C., Mayor, U., Clague, M. J., & Whitworth, A. J.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2018-03-02
- Volume
- 217
- Issue
- 5
- Pages
- 1613-1622
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2787965853
- Cited by
- 348
- References
- 40
- FWCI
- 29.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lee, J. J., Sanchez-Martinez, A., Zarate, A. M., Benincá, C., Mayor, U., Clague, M. J., & Whitworth, A. J. (2018). Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin. Journal of Cell Biology. https://doi.org/10.1083/jcb.201801044
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