The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Glutathione metabolism in cancer progression and treatment resistance
Open accessAbstract
Glutathione (GSH) is the most abundant antioxidant found in living organisms and has multiple functions, most of which maintain cellular redox homeostasis. GSH preserves sufficient levels of cysteine and detoxifies xenobiotics while also conferring therapeutic resistance to cancer cells. However, GSH metabolism plays both beneficial and pathogenic roles in a variety of malignancies. It is crucial to the removal and detoxification of carcinogens, and alterations in this pathway can have a profound effect on cell survival. Excess GSH promotes tumor progression, where elevated levels correlate with increased metastasis. In this review, we discuss recent studies that focus on deciphering the role of GSH in tumor initiation and progression as well as mechanisms underlying how GSH imparts treatment resistance to growing cancers. Targeting GSH synthesis/utilization therefore represents a potential means of rendering tumor cells more susceptible to different treatment options such as chemotherapy and radiotherapy.
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Cites
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Mechanisms of Multidrug Resistance in Cancer Chemotherapy
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Oxidative cell death in cancer: mechanisms and therapeutic opportunities
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Metadata
- Authors
- Bansal, A., & Simon, M. C.
- Venue
- Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2018-06-18
- Volume
- 217
- Issue
- 7
- Pages
- 2291-2298
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2809388839
- Cited by
- 1,233
- References
- 21
- FWCI
- 31.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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