Cited by 1,266Sulfur Compounds in BiologyGlutathione Transferases and PolymorphismsRedox biology and oxidative stress

Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions

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Lushchak, Volodymyr I.·2012·Journal of Amino Acids

Abstract

Glutathione (GSH) is a tripeptide, which has many biological roles including protection against reactive oxygen and nitrogen species. The primary goal of this paper is to characterize the principal mechanisms of the protective role of GSH against reactive species and electrophiles. The ancillary goals are to provide up-to-date knowledge of GSH biosynthesis, hydrolysis, and utilization; intracellular compartmentalization and interorgan transfer; elimination of endogenously produced toxicants; involvement in metal homeostasis; glutathione-related enzymes and their regulation; glutathionylation of sulfhydryls. Individual sections are devoted to the relationships between GSH homeostasis and pathologies as well as to developed research tools and pharmacological approaches to manipulating GSH levels. Special attention is paid to compounds mainly of a natural origin (phytochemicals) which affect GSH-related processes. The paper provides starting points for development of novel tools and provides a hypothesis for investigation of the physiology and biochemistry of glutathione with a focus on human and animal health.

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Authors
Lushchak, V. I.
Affiliations
Vasyl Stefanyk Carpathian National University (UA)
Corresponding author
Lushchak, Volodymyr I.
Venue
Journal of Amino Acids
Publisher
Wiley
Published
2012-02-28
Volume
2012
Pages
1-26
ISSN
  • 2090-0104 (ISSN-L)
  • 2090-0112
OpenAlex
W2043037824
Cited by
1,266
References
283
Citations by year
2026: 70 · 2025: 117 · 2024: 119 · 2023: 126 · 2022: 125 · 2021: 131 · 2020: 110 · 2019: 79 · 2018: 76 · 2017: 93 · 2016: 64 · 2015: 64 · 2014: 52 · 2013: 29 · 2012: 7
FWCI
20.84
Type
journal article
Language
en
Open access
Locations
  • Journal of Amino Acids (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Ministry of Education and Science of Ukraine (0106U002245)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glutathione Transferases and Polymorphisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
glutathione, glutathione homeostasis, reactive oxygen species, reactive nitrogen species, glutathione synthesis, glutathione metabolism, metal homeostasis, glutathionylation, sulfhydryl groups, phytochemicals, disease pathology

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