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Cited by 408

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

ELECTRON MICROSCOPIC STUDIES OF INDUCED CARTILAGE DEVELOPMENT AND CALCIFICATION

Open access
Anderson, H. Clarke·1967·The Journal of Cell Biology

Abstract

Cultured, human, amniotic cells (FL strain) injected into the thigh muscles of cortisone-conditioned mice proliferated to form discrete colonies which, over a period of 5 days, became invested by numerous fibroblasts. Cartilage cells and matrix appeared within the fibroblastic zones during the succeeding 2–4 days. Cartilage matrix calcified within 12 days following FL-cell injection. Cartilage cells closely resembled fibroblasts from which they appeared to be derived, and were readily distinguished from FL cells by their prominent ergastoplasm and Golgi complexes. Cartilage matrix was composed of a distinctive feltwork of randomly arranged, collagen fibrils (∼600 A axial period and ∼250 A width) from which small electron-opaque, leaflike matrix particles extended. Matrix calcification occurred with the deposition of radially arranged needle-like structures resembling hydroxyapatite. Dense centers were often identified within these clusters. Examination of heavily calcified areas revealed confluent masses of apatite-like material. In general, the fine structure of induced cartilage formation and calcification resembled that of cartilage development and calcification as previously described in the normal epiphysis.

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Metadata

Authors
Anderson, H. C.
Venue
The Journal of Cell Biology
Published
1967-10-01
Volume
35
Issue
1
Pages
81-101
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
OpenAlex
W2127748297
Cited by
408
References
33
FWCI
10.65
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: ELECTRON MICROSCOPIC STUDIES OF INDUCED CARTILAGE DEVELOPMENT AND CALCIFICATION. https://app.cochat.ai/papers/10.1083/jcb.35.1.81
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Anderson, H. C. (1967). ELECTRON MICROSCOPIC STUDIES OF INDUCED CARTILAGE DEVELOPMENT AND CALCIFICATION. The Journal of Cell Biology. https://doi.org/10.1083/jcb.35.1.81

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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