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THE AXON HILLOCK AND THE INITIAL SEGMENT
Open accessAbstract
Axon hillocks and initial segments have been recognized and studied in electron micrographs of a wide variety of neurons. In all multipolar neurons the fine structure of the initial segment has the same pattern, whether or not the axon is ensheathed in myelin. The internal structure of the initial segment is characterized by three special features: (a) a dense layer of finely granular material undercoating the plasma membrane, (b) scattered clusters of ribosomes, and (c) fascicles of microtubules. A similar undercoating occurs beneath the plasma membrane of myelinated axons at nodes of Ranvier. The ribosomes are not organized into Nissl bodies and are too sparsely distributed to produce basophilia. They vanish at the end of the initial segment. Fascicles of microtubules occur only in the axon hillock and initial segment and nowhere else in the neuron. Therefore, they are the principal identifying mark. Some speculations are presented on the relation between these special structural features and the special function of the initial segment.
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Citations
Cites
Characteristics of Excitatory and Inhibitory Synapses in the Central Nervous System of the Cat
UCHIZONO, K. (1965) · Nature · doi:10.1038/207642a0 · Cited by 917
Cited by
DeFelipe, J., & Fariñas, I. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90015-7 · Cited by 975
Pan, Z., Kao, T., Horvath, Z., Lemos, J., Sul, J.-Y., Cranstoun, S. D., Bennett, V., Scherer, S. S., & Cooper, E. C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4314-05.2006 · Cited by 585
A specific ‘axo-axonal’ interneuron in the visual cortex of the rat
Somogyi, P. (1977) · Brain Research · doi:10.1016/0006-8993(77)90808-3 · Cited by 530
Signal processing in the axon initial segment
Kole, M. H. P., & Stuart, G. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.007 · Cited by 463
The axon initial segment and the maintenance of neuronal polarity
Rasband, M. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2852 · Cited by 442
Metadata
- Authors
- Palay, S. L., Sotelo, C., Peters, A., & Orkand, P. M.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1968-07-01
- Volume
- 38
- Issue
- 1
- Pages
- 193-201
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W1983765259
- Cited by
- 482
- References
- 1
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Palay, S. L., Sotelo, C., Peters, A., & Orkand, P. M. (1968). THE AXON HILLOCK AND THE INITIAL SEGMENT. The Journal of Cell Biology. https://doi.org/10.1083/jcb.38.1.193
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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