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Cited by 482

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

THE AXON HILLOCK AND THE INITIAL SEGMENT

Open access
Palay, Sanford L., Sotelo, Constantino, Peters, Alan, Orkand, Paula M.·1968·The Journal of Cell Biology

Abstract

Axon hillocks and initial segments have been recognized and studied in electron micrographs of a wide variety of neurons. In all multipolar neurons the fine structure of the initial segment has the same pattern, whether or not the axon is ensheathed in myelin. The internal structure of the initial segment is characterized by three special features: (a) a dense layer of finely granular material undercoating the plasma membrane, (b) scattered clusters of ribosomes, and (c) fascicles of microtubules. A similar undercoating occurs beneath the plasma membrane of myelinated axons at nodes of Ranvier. The ribosomes are not organized into Nissl bodies and are too sparsely distributed to produce basophilia. They vanish at the end of the initial segment. Fascicles of microtubules occur only in the axon hillock and initial segment and nowhere else in the neuron. Therefore, they are the principal identifying mark. Some speculations are presented on the relation between these special structural features and the special function of the initial segment.

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Crossref · 10.1083/jcb.38.1.193

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Metadata

Authors
Palay, S. L., Sotelo, C., Peters, A., & Orkand, P. M.
Venue
The Journal of Cell Biology
Published
1968-07-01
Volume
38
Issue
1
Pages
193-201
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
OpenAlex
W1983765259
Cited by
482
References
1
FWCI
13.35
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: THE AXON HILLOCK AND THE INITIAL SEGMENT. https://app.cochat.ai/papers/10.1083/jcb.38.1.193
The paper
Palay, S. L., Sotelo, C., Peters, A., & Orkand, P. M. (1968). THE AXON HILLOCK AND THE INITIAL SEGMENT. The Journal of Cell Biology. https://doi.org/10.1083/jcb.38.1.193

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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