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Cited by 677

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

VARIATIONS IN TIGHT AND GAP JUNCTIONS IN MAMMALIAN TISSUES

Open access
Friend, Daniel S., Gilula, Norton B.·1972·The Journal of Cell Biology
DOI 10.1083/jcb.53.3.758
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Abstract

The fine structure and distribution of tight (zonula occludens) and gap junctions in epithelia of the rat pancreas, liver, adrenal cortex, epididymis, and duodenum, and in smooth muscle were examined in paraformaldehyde-glutaraldehyde-fixed, tracer-permeated (K-pyroantimonate and lanthanum), and freeze-fractured tissue preparations. While many pentalaminar and septilaminar foci seen in thin-section and tracer preparations can be recognized as corresponding to well-characterized freeze-fracture images of tight and gap junction membrane modifications, many others cannot be unequivocally categorized—nor can all freeze-etched aggregates of membrane particles. Generally, epithelia of exocrine glands (pancreas and liver) have moderate-sized tight junctions and large gap junctions, with many of their gap junctions basal to the junctional complex. In contrast, the adrenal cortex, a ductless gland, may not have a tight junction but does possess large gap junctions. Mucosal epithelia (epididymis and intestine) have extensive tight junctions, but their gap junctions are not as well developed as those of glandular tissue. Smooth muscle contains numerous small gap junctions The incidence, size, and configuration of the junctions we observed correlate well with the known functions of the junctions and of the tissues where they are found.

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Metadata

Authors
Friend, D. S., & Gilula, N. B.
Venue
The Journal of Cell Biology
Publisher
Rockefeller University Press
Published
1972-06-01
Volume
53
Issue
3
Pages
758-776
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.53.3.758
OpenAlex
W2099321759
Cited by
677
References
22
FWCI
21.68
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: VARIATIONS IN TIGHT AND GAP JUNCTIONS IN MAMMALIAN TISSUES. https://app.cochat.ai/papers/10.1083/jcb.53.3.758
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Friend, D. S., & Gilula, N. B. (1972). VARIATIONS IN TIGHT AND GAP JUNCTIONS IN MAMMALIAN TISSUES. The Journal of Cell Biology. https://doi.org/10.1083/jcb.53.3.758

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