The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
PROTEIN DEGRADATION IN CULTURED CELLS
Open accessAbstract
The degradation of cellular proteins in fibroblasts, both those of rapid and those of slow turnover rates, was inhibited by low concentrations of chloroquine or neutral red in the medium. Cells inhibited by chloroquine can be inhibited further by fluoride. Chloroquine was taken up by the fibroblasts and the concentration in the cells reached several hundred times that in the medium. Isopycnic fractionation studies showed that within the cells the chloroquine was concentrated in the lysosomes, and that these chloroquine-containing lysosomes had a lower equilibrium density than the lysosomes of untreated cells. Chloroquine, at concentrations attained inside the lysosomes, inhibited cathepsin B1 but not cathepsin D. It is concluded that chloroquine impairs the breakdown of cellular proteins after these have entered the lysosome system, probably through inhibition of cathepsin B1.
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de Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033 · cited 2×
“The lysosomal pH (8, 13) can account for an extensive accumulation of a weak base such as chloroquine (12) inside these particles.”
Background
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Brown, M. S., & Goldstein, J. L. (1976) · Science · doi:10.1126/science.174194 · Cited by 725
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Metadata
- Authors
- Wibo, M., & Poole, B.
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 1974-11-01
- Volume
- 63
- Issue
- 2
- Pages
- 430-440
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2095894333
- Cited by
- 598
- References
- 1
- FWCI
- 24.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Wibo, M., & Poole, B. (1974). PROTEIN DEGRADATION IN CULTURED CELLS. The Journal of Cell Biology. https://doi.org/10.1083/jcb.63.2.430
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
