The DOI matches its Crossref record.
Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate.
Open accessAbstract
Whole blood serum is widely recognized as essential for the growth of diploid cells in culture. Dermal fibroblasts and arterial smooth muscle cells fail to proliferate in culture in the presence of serum derived from platelet-poor plasma. Platelet-poor plasma serum is capable of maintaining monkey arterial smooth muscle cells quiescent in culture at either low (1.5 x 10(3)) or high (2.0 x 10(4)) population densities. The proportion of cell traversing the cell cycle under these conditions was approximately 3%. Equal numbers of quiescent smooth muscle cells initiated DNA synthesis and cell division when treated with whole blood serum or with an equivalent quantity of platelet-poor plasma serum supplemented with a factor(s) derived from a supernate obtained after exposure of human platelets to purified thrombin in vitro.
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Citations
Cited by
PLATELET-DERIVED GROWTH FACTOR
Ross, R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92760-8 · Cited by 940
Self-citationSerruys, P. W., Luijten, H. E., Beatt, K. J., Geuskens, R., de Feyter, P. J., van den Brand, M., Reiber, J. H., ten Katen, H. J., van Es, G. A., & Hugenholtz, P. G. (1988) · Circulation · doi:10.1161/01.cir.77.2.361 · Cited by 931
Phenotype-dependent response of cultured aortic smooth muscle to serum mitogens.
Chamley-Campbell, J. H., Campbell, G. R., & Ross, R. (1981) · The Journal of cell biology · doi:10.1083/jcb.89.2.379 · Cited by 444
Self-citationAn antiproliferative heparan sulfate species produced by postconfluent smooth muscle cells.
Fritze, L. M., Reilly, C. F., & Rosenberg, R. D. (1985) · The Journal of cell biology · doi:10.1083/jcb.100.4.1041 · Cited by 313
Collagen in Dermal Wound Repair
McPherson, J. M., & Piez, K. A. (1988) · The Molecular and Cellular Biology of Wound Repair · doi:10.1007/978-1-4615-1795-5_20 · Cited by 39
Metadata
- Authors
- Rutherford, R. B., & Ross, R.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1976-04-01
- Volume
- 69
- Issue
- 1
- Pages
- 196-203
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2109517079
- Cited by
- 398
- References
- 0
- FWCI
- 30.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Rutherford, R. B., & Ross, R. (1976). Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate. The Journal of cell biology. https://doi.org/10.1083/jcb.69.1.196
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
