Cited by 931Coronary Interventions and DiagnosticsAcute Myocardial Infarction ResearchCardiac Imaging and Diagnostics

Incidence of restenosis after successful coronary angioplasty: a time-related phenomenon. A quantitative angiographic study in 342 consecutive patients at 1, 2, 3, and 4 months.

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Serruys, P W, Luijten, H E, Beatt, K J, Geuskens, R, de Feyter, P J, van den Brand, M, Reiber, J H, ten Katen, H J +2 more·1988·Circulation

Abstract

Data from experimental, clinical, and pathologic studies have suggested that the process of restenosis begins very early after coronary angioplasty. The present study was performed to determine prospectively the incidence of restenosis with use of the four National Heart, Lung, and Blood Institute and the 50% or greater diameter stenosis criteria, as well as a criterion based on a decrease of 0.72 mm or more in minimal luminal diameter. Patients were recatheterized at 30, 60, 90, or 120 days after successful percutaneous transluminal coronary angioplasty (PTCA). After PTCA all patients received 10 mg nifedipine three to six times a day and aspirin once a day until repeat angiography. Of 400 consecutive patients in whom PTCA was successful (less than 50% diameter stenosis), 342 underwent quantitative angiographic follow-up (86%) by use of an automated edge-detection technique. A wide variation in the incidence of restenosis was found dependent on the criterion applied. The incidence of restenosis proved to be progressive to at least the third month for all except NHLBI criterion II. At 4 months a further increase in the incidence of restenosis was observed when defined as a decrease of 0.72 mm or more in minimal luminal diameter, whereas the criteria based on percentage diameter stenosis showed a variable response. The lack of overlap between the different restenosis criteria applied affirms the arbitrary nature of angiographic definitions currently in use. Restenosis should be assessed by repeat angiography, and preferably ascertained according to the change in absolute quantitative measurements of the luminal diameter.

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Crossref · 10.1161/01.cir.77.2.361

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Authors
Serruys, P. W., Luijten, H. E., Beatt, K. J., Geuskens, R., de Feyter, P. J., van den Brand, M., Reiber, J. H., ten Katen, H. J., van Es, G. A., & Hugenholtz, P. G.
Affiliations
  • Erasmus University Rotterdam (NL)
  • Thoraxcenter, Erasmus University, Rotterdam, The Netherlands.
Venue
Circulation
Published
1988-02
Volume
77
Issue
2
Pages
361-371
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
OpenAlex
W2107392339
Cited by
931
References
34
Citations by year
2026: 6 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 12 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 20 · 2015: 11 · 2014: 15 · 2013: 18 · 2012: 9
FWCI
55.81
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
Keywords
coronary restenosis, percutaneous transluminal coronary angioplasty, quantitative coronary angiography, minimal lumen diameter, nifedipine, aspirin, repeat angiography
MeSH terms
Adult, Aged, Angioplasty, Balloon, Coronary Disease, Coronary Vessels, Female, Follow-Up Studies, Humans, Male, Middle Aged, Recurrence, Vascular Patency, Coronary Angiography

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