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Cited by 444

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Phenotype-dependent response of cultured aortic smooth muscle to serum mitogens.

Open access
Chamley-Campbell, J H, Campbell, G R, Ross, R·1981·The Journal of cell biology
DOI 10.1083/jcb.89.2.379
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Abstract

Smooth muscle cells from the aortic media of adult pigs and monkeys have been grown in primary culture by plating cells enzymatically dissociated from the intact aorta. During the first 6 d these cells are in the "contractile" phenotype. That is, they contract slowly in response to angiotensin II and their cytoplasm is filled with both thick and thin myofilaments. In this state they do not incorporate [3H]thymidine into DNA or proliferate in response to normolipemic or hyperlipemic whole blood serum (WBS). After 7 d in culture the cells undergo a spontaneous modulation of phenotype to a "synthetic" state where they cannot be stimulated to contract and their cytoplasm is filled with organelles usually associated with synthesis of secretory protein. Thick myosin-containing filaments can no longer be demonstrated. When challenged with normolipemic or hyperlipemic WBS the cells incorporate [3H]thymidine into DNA and undergo logarithmic growth. It is suggested that when smooth muscle is the contractile phenotype (as normally exists for most cells in the aortic media of adult animals) it does not divide when challenged with serum mitogens but can undergo a change of phenotype to a synthetic state in which division can be stimulated.

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Metadata

Authors
Chamley-Campbell, J. H., Campbell, G. R., & Ross, R.
Venue
The Journal of cell biology
Publisher
Rockefeller University Press
Published
1981-05-01
Volume
89
Issue
2
Pages
379-383
ISSN
  • 0021-9525 (ISSN-L)
  • 1540-8140
DOI
10.1083/jcb.89.2.379
OpenAlex
W1970366992
Cited by
444
References
19
FWCI
5.77
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Phenotype-dependent response of cultured aortic smooth muscle to serum mitogens. https://app.cochat.ai/papers/10.1083/jcb.89.2.379
The paper
Chamley-Campbell, J. H., Campbell, G. R., & Ross, R. (1981). Phenotype-dependent response of cultured aortic smooth muscle to serum mitogens. The Journal of cell biology. https://doi.org/10.1083/jcb.89.2.379

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.