The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Membrane receptors for hormones and neurotransmitters.
Open accessAbstract
Receptors for peptide hormones and neurotransmitters are integral components of the plasma membrane of cells which serve to couple the external milieu to the intracellular regulators of metabolism. These macromolecules are usually high molecular weight glycoproteins, and in many cases appear to have more than one subunit capable of binding the hormone. The interaction of the hormone or neurotransmitter with its receptor is rapid, reversible, and of high affinity and specificity. Many receptors exhibit cooperative properties in hormone binding or biological function. The concentration of receptors on the membrane is a function of continued synthesis and degradation, and may be altered by a variety of factors including the hormone itself. The fluid mosaic nature of the membrane may allow hormone receptors and effectors to exist in free floating states. Further investigations of the hormone-receptor interaction will no doubt yield new insights into both the mechanism of hormone action and membrane structure and function.
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Cites
Tolbert, M. E. M., Butcher, F. R., & Fain, J. N. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43560-6 · Cited by 171 · cited 1×
“In liver, for example, catecholamine effects on glycogenolysis appear to be mediated via cAMP while those on gluconeogenesis do not (148).”
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Cited by
Hill, J. M., Lesniak, M. A., Pert, C. B., & Roth, J. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90082-5 · Cited by 413
Direct demonstration that receptor crosslinking or aggregation is important in insulin action
Kahn, C. R., Baird, K. L., Jarrett, D. B., & Flier, J. S. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4209 · Cited by 389
Self-citationInsulin transport across capillaries is rate limiting for insulin action in dogs.
Yang, Y. J., Hope, I. D., Ader, M., & Bergman, R. N. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114339 · Cited by 303
Insulin and insulin receptors in rodent brain
Havrankova, J., Brownstein, M., & Roth, J. (1981) · Diabetologia · doi:10.1007/bf00254492 · Cited by 201
Lipoprotein-receptor interactions
Innerarity, T. L., Pitas, R. E., & Mahley, R. W. (1986) · Methods in Enzymology · doi:10.1016/0076-6879(86)29091-6 · Cited by 186
Metadata
- Authors
- Kahn, C. R.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1976-08-01
- Volume
- 70
- Issue
- 2
- Pages
- 261-286
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2122556355
- Cited by
- 569
- References
- 1
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Kahn, C. R. (1976). Membrane receptors for hormones and neurotransmitters. The Journal of cell biology. https://doi.org/10.1083/jcb.70.2.261
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
