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pH regulates the polymerization of actin in the sea urchin egg cortex.
Open accessAbstract
The state of actin in the isolated cortex of the unfertilized sea urchin egg can be controlled by experimentally manipulating the pH of the isolation medium. Cortices isolated at the pH of the unfertilized egg (6.5--6.7) do not contain filamentous actin, while those isolated at the pH of the fertilized egg (7.3--7.5) develop large numbers of microvilli which contain bundles of actin filaments. Cortices that are isolated at pH 6.5 and then transferred to isolation medium buffered at pH 7.5 also develop actin filaments. However, the filaments are not arranged in bundles and microvilli do not form. Although the cortical granules in cortices isolated at pH 6.5 discharge at a free Ca++ concentration of approximately 10 micrometer, actin polymerization is not induced by increasing the Ca++ concentration of the isolation medium. These results suggest that the increase in cytoplasmic pH which occurs following fertilization induces the polymerization of actin in the egg cortex.
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Cited by
Metabolic regulation via intracellular pH
Busa, W. B., & Nuccitelli, R. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.4.r409 · Cited by 665
Calcium at Fertilization and in Early Development
Whitaker, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00023.2005 · Cited by 512
An actin-dependent mechanism for long-range vesicle transport
Schuh, M. (2011) · Nature Cell Biology · doi:10.1038/ncb2353 · Cited by 324
Analysis of cytoskeletal and motility proteins in the sea urchin genome assembly
Morris, R. L., Hoffman, M. P., Obar, R. A., McCafferty, S. S., Gibbons, I. R., Leone, A. D., Cool, J., Allgood, E. L., Musante, A. M., Judkins, K. M., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.052 · Cited by 60
Metadata
- Authors
- Begg, D. A., & Rebhun, L. I.
- Venue
- The Journal of cell biology
- Publisher
- Rockefeller University Press
- Published
- 1979-10-01
- Volume
- 83
- Issue
- 1
- Pages
- 241-248
- ISSN
- 0021-9525 (ISSN-L)
- 1540-8140
- OpenAlex
- W2147822472
- Cited by
- 201
- References
- 0
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Begg, D. A., & Rebhun, L. I. (1979). pH regulates the polymerization of actin in the sea urchin egg cortex. The Journal of cell biology. https://doi.org/10.1083/jcb.83.1.241
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