The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Metabolic regulation via intracellular pH
Abstract
Despite earlier notions that intracellular pH (pHi) was invariant with time, recent studies have documented pHi changes of from 0.1 to 1.6 U during metabolic and developmental transitions in a variety of cells. Here we review the evidence for pHi-mediated regulation of gamete activation, cellular dormancy, the cell cycle, and stimulus-response coupling. Intracellular Ca2+ level changes also accompany many of these same transitions, and mounting evidence suggests that pHi and Ca2+ changes can be interdependent, both in their mechanisms and their effects. Although the significance of such interactions is still largely unclear, one example--the pronounced pH dependence of Ca2+ binding by calmodulin--suggests their potential importance in metabolic regulation. Similar evidence suggests that pHi changes also influence intracellular adenosine 3',5'-cyclic monophosphate levels, and vice versa. Finally we show that changes in adenylate energy charge can significantly alter pHi. In light of these interactions--and because pHi, unlike most other effectors, does not require specialized receptors--we suggest that pHi functions as a synergistic messenger, providing a metabolic context within and through which the actions of other effectors are integrated.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Thomas, J. A., Buchsbaum, R. N., Zimniak, A., & Racker, E. (1979) · Biochemistry · doi:10.1021/bi00578a012 · Cited by 2,132
Waterfield, M. D., Scrace, G. T., Whittle, N., Stroobant, P., Johnsson, A., Wasteson, Å., Westermark, B., Heldin, C.-H., Huang, J. S., & Deuel, T. F. (1983) · Nature · doi:10.1038/304035a0 · Cited by 1,616
Doolittle, R. F., Hunkapiller, M. W., Hood, L. E., Devare, S. G., Robbins, K. C., Aaronson, S. A., & Antoniades, H. N. (1983) · Science · doi:10.1126/science.6304883 · Cited by 1,536
Amiloride: a molecular probe of sodium transport in tissues and cells
Benos, D. J. (1982) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1982.242.3.c131 · Cited by 839
Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages.
Poole, B., & Ohkuma, S. (1981) · The Journal of cell biology · doi:10.1083/jcb.90.3.665 · Cited by 751
Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts
Moolenaar, W. H., Tsien, R. Y., van der Saag, P. T., & de Laat, S. W. (1983) · Nature · doi:10.1038/304645a0 · Cited by 707
Effect of pH on the Kinetics of Frog Muscle Phosphofructokinase
Trivedi, B., & Danforth, W. H. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99819-4 · Cited by 669
Hochachka, P. W., & Mommsen, T. P. (1983) · Science · doi:10.1126/science.6298937 · Cited by 578
Gibbons, B. H., & Gibbons, I. R. (1972) · The Journal of Cell Biology · doi:10.1083/jcb.54.1.75 · Cited by 570
Intracellular pH and Activation of Sea Urchin Eggs after Fertilisation
Johnson, J. D., Epel, D., & Paul, M. (1976) · Nature · doi:10.1038/262661a0 · Cited by 556
Cited by
(1989) · PubMed · Cited by 1,639
Biochemistry of exercise-induced metabolic acidosis
Robergs, R. A., Ghiasvand, F., & Parker, D. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00114.2004 · Cited by 1,304
The effects of extracellular pH on immune function
Lardner, A. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.4.522 · Cited by 864
GATTUSO, J.-P., ALLEMAND, D., & FRANKIGNOULLE, M. (1999) · American Zoologist · doi:10.1093/icb/39.1.160 · Cited by 709
Identification of an adult-specific glial progenitor cell
Wolswijk, G., & Noble, M. (1989) · Development · doi:10.1242/dev.105.2.387 · Cited by 485
Metadata
- Authors
- Busa, W. B., & Nuccitelli, R.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 1984-04-01
- Volume
- 246
- Issue
- 4
- Pages
- R409-R438
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W1790873293
- Cited by
- 665
- References
- 83
- FWCI
- 13.49
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Metabolic regulation via intracellular pH. https://app.cochat.ai/papers/10.1152/ajpregu.1984.246.4.r409
- The paper
- Busa, W. B., & Nuccitelli, R. (1984). Metabolic regulation via intracellular pH. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. https://doi.org/10.1152/ajpregu.1984.246.4.r409
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
