Analysis of cytoskeletal and motility proteins in the sea urchin genome assembly
Open accessAbstract
The sea urchin embryo is a classical model system for studying the role of the cytoskeleton in such events as fertilization, mitosis, cleavage, cell migration and gastrulation. We have conducted an analysis of gene models derived from the Strongylocentrotus purpuratus genome assembly and have gathered strong evidence for the existence of multiple gene families encoding cytoskeletal proteins and their regulators in sea urchin. While many cytoskeletal genes have been cloned from sea urchin with sequences already existing in public databases, genome analysis reveals a significantly higher degree of diversity within certain gene families. Furthermore, genes are described corresponding to homologs of cytoskeletal proteins not previously documented in sea urchins. To illustrate the varying degree of sequence diversity that exists within cytoskeletal gene families, we conducted an analysis of genes encoding actins, specific actin-binding proteins, myosins, tubulins, kinesins, dyneins, specific microtubule-associated proteins, and intermediate filaments. We conducted ontological analysis of select genes to better understand the relatedness of urchin cytoskeletal genes to those of other deuterostomes. We analyzed developmental expression (EST) data to confirm the existence of select gene models and to understand their differential expression during various stages of early development.
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In addition to all previously known S. purpuratus actins and tubulins, one delta-tubulin and two epsilon-tubulin genes were found.
“In addition to identifying genes for all previously known S. purpuratus actins and tubulins, one δand two ε-tubulin genes were found (52).”
From The Genome of the Sea Urchin <i>Strongylocentrotus purpuratus</i> (2006) · cites this paper as [52]
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The Genome of the Sea Urchin <i>Strongylocentrotus purpuratus</i>
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Twenty‐five dyneins in Tetrahymena: A re‐examination of the multidynein hypothesis
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Novel 44-Kilodalton Subunit of Axonemal Dynein Conserved from Chlamydomonas to Mammals
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Gene Polymorphisms in Boar Spermatozoa and Their Associations with Post-Thaw Semen Quality
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Composition and function of ciliary inner‐dynein‐arm subunits studied in Chlamydomonas reinhardtii
Yamamoto, R., Hwang, J., Ishikawa, T., Kon, T., & Sale, W. S. (2021) · Cytoskeleton · doi:10.1002/cm.21662 · Cited by 43 · see citing works
Distinct roles of 1α and 1β heavy chains of the inner arm dynein I1 ofChlamydomonasflagella
Toba, S., Fox, L. A., Sakakibara, H., Porter, M. E., Oiwa, K., & Sale, W. S. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-10-0806 · Cited by 34 · see citing works
Hedgehog Signaling Requires Motile Cilia in the Sea Urchin
Warner, J. F., McCarthy, A. M., Morris, R. L., & McClay, D. R. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst176 · Cited by 34 · see citing works
Self-citationBranco, P. C., Pressinotti, L. N., Borges, J. C. S., Iunes, R. S., Kfoury, J. R., da Silva, M. O., González‐Aravena, M., dos Santos, M. F., Peck, L. S., Cooper, E. L., et al. (2011) · Polar Biology · doi:10.1007/s00300-011-1063-5 · Cited by 33 · see citing works
Roux, M. M., Radeke, M. J., Goel, M., Mushegian, A. R., & Foltz, K. R. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.10.053 · Cited by 31 · see citing works
High Throughput Microinjections of Sea Urchin Zygotes
Stepicheva, N. A., & Song, J. L. (2014) · Journal of Visualized Experiments · doi:10.3791/50841 · Cited by 29 · see citing works
Bioinformatic Approaches to Dynein Heavy Chain Classification
Yagi, T. (2009) · Methods in cell biology · doi:10.1016/s0091-679x(08)92001-x · Cited by 24 · see citing works
Evolutionary Biology of Dyneins
Wickstead, B., & Keith Gull, B. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382004-4.10002-0 · Cited by 23 · see citing works
Sonobe, H., Obinata, T., Minokawa, T., Haruta, T., Kawamura, Y., Wakatsuki, S., & Sato, N. (2016) · The Journal of Biochemistry · doi:10.1093/jb/mvw047 · Cited by 14 · see citing works
Troponin-I is present as an essential component of muscles in echinoderm larvae
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Loza-Huerta, A., Vera‐Estrella, R., Darszon, A., & Beltrán, C. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.07.029 · Cited by 13 · see citing works
Intermediate filament genes as differentiation markers in the leech Helobdella
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The evolutionary biology of dyneins
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Purification and assay of mitotic motors
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Huang, Z.-Q., & Zhang, G. (2011) · Biochemistry (Moscow) · doi:10.1134/s0006297911110046 · Cited by 8 · see citing works
Discovery of Dynein and its Properties
Gibbons, I. R. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382004-4.10001-9 · Cited by 8 · see citing works
Self-citationCytoplasmic Dynein Function Defined by Subunit Composition
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Evolution of the Dynein Heavy Chain Family in Ciliates
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Control of axonemal inner dynein arms
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Characterization of Native Myosin VI Isolated from Sea Urchin Eggs
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Genetic Approaches to Axonemal Dynein Function in Chlamydomonas and Other Organisms
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Discovery of dynein and its properties
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Perspective: Examining MAP1B Structure With an Evolutionary Perspective
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Control of Axonemal Inner Dynein Arms
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Role of Molecular Motors in Endosomal Dynamics: A review
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Force-Generating Mechanisms of Dynein Revealed through Single Molecule Studies
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Genetic approaches to axonemal dynein function in Chlamydomonas and other organisms
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Ian Read Gibbons. 30 October 1931—30 January 2018
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Cytoplasmic dynein function defined by subunit composition
Pfister, K. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809471-6.00014-0
Kamiya, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-809633-8.08070-5
- Authors
- Morris, R. L., Hoffman, M. P., Obar, R. A., McCafferty, S. S., Gibbons, I. R., Leone, A. D., Cool, J., Allgood, E. L., Musante, A. M., Judkins, K. M., Rossetti, B. J., Rawson, A. P., & Burgess, D. R.
- Affiliations
- Wheaton College - Massachusetts (US)
- Boston College (US)
- Tethys Research (United States) (US)
- University of California, Berkeley (US)
- Corresponding author
- Morris, R.L.
- Burgess, D.R.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 300
- Issue
- 1
- Pages
- 219-237
- ISSN
- 0012-1606 (ISSN-L)
- PMC
- PMC2590651
- OpenAlex
- W2043023410
- Cited by
- 60
- References
- 118
- Citations by year
- 2025: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 6 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 3
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Boston College
- National Institutes of Health
- National Institute of General Medical Sciences (GM58231, R01GM030401, GM30401, R01GM058231, R37GM030401)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- sea urchins, Strongylocentrotus purpuratus, cytoskeleton, actin, actin-binding proteins, myosin, tubulin, kinesin, dynein, microtubule-associated proteins, intermediate filaments, Gene Ontology, deuterostomes, early embryonic development, gene expression, gastrulation, cell migration
- MeSH terms
- Animals, Cytoskeletal Proteins, Multigene Family, Humans, Intermediate Filament Proteins, Myosins, Phylogeny, Sea Urchins, Tubulin, Genome, Gene Expression Regulation, Developmental, Molecular Motor Proteins
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