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GENETICS OF SOMATIC MAMMALIAN CELLS
Open accessAbstract
A methodology designed to eliminate mitotic inhibitor action and involving use of pretested fetal calf serum and careful pH and temperature control has been described by which cells from normal human and animal tissue can be maintained in active growth for long periods in vitro without development of aneuploidy. By means of this procedure, it is possible reliably to establish cell cultures from minute skin biopsies which can be taken from any individual. Clones of mammalian cells with chromosomal markers have been isolated by this means from x-irradiated non-irradiated cell cultures. Application of these techniques to chromosome delineation in large numbers of human subjects; determination of chromosomal sex in patients; spontaneuos and induced genetic changes in somatic mammalian cells in vivo and in vitro; comparison of metabolic differences between normal and cancerous cells and other problems have been indicated.
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Citations
Cited by
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
Clonal growth of mammalian cells in a chemically defined, synthetic medium
Ham, R. G. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.53.2.288 · Cited by 837
Established eurythermic line of fish cells in vitro
Wolf, K., & Quimby, M. C. (1962) · Science · doi:10.1126/science.135.3508.1065 · Cited by 638
Astrocyte Senescence as a Component of Alzheimer’s Disease
Bhat, R., Crowe, E. P., Bitto, A., Moh, M., Katsetos, C. D., Garcia, F. U., Johnson, F. B., Trojanowski, J. Q., Sell, C., & Torres, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045069 · Cited by 586
Fetal Bovine Serum (FBS): past ‐ present ‐ future
van der Valk, J. (2018) · ALTEX · doi:10.14573/altex.1705101 · Cited by 481
Metadata
- Authors
- Puck, T. T., Cieciura, S. J., & Robinson, A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1958-12-01
- Volume
- 108
- Issue
- 6
- Pages
- 945-956
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2047207866
- Cited by
- 960
- References
- 0
- FWCI
- 32.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Puck, T. T., Cieciura, S. J., & Robinson, A. (1958). GENETICS OF SOMATIC MAMMALIAN CELLS. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.108.6.945
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
