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Cited by 143Gut microbiota and healthProbiotics and Fermented FoodsEscherichia coli research studies

THE FECAL FLORA OF VARIOUS STRAINS OF MICE. ITS BEARING ON THEIR SUSCEPTIBILITY TO ENDOTOXIN

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Schaedler, Russell W., Dubos, René J.·1962·The Journal of Experimental Medicine
DOI 10.1084/jem.115.6.1149PMC PMC2137400
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Abstract

Adult mice from seven different colonies were studied with regard to (a) the numbers and types of bacteria that could be cultivated from their stools; (b) their resistance to the lethal effect of endotoxins prepared from three strains of Gram-negative bacilli. See PDF for Structure In six of the seven colonies, the stools yielded large numbers of various types of lactobacilli, enterococci, and Gram-negative bacilli. Most animals in these colonies died within 48 hours following injection of endotoxin. The other mouse colony (NCS) has been maintained for the past three years at the Rockefeller Institute under exacting sanitary conditions; it is free of many types of common mouse pathogens. The stool flora of NCS mice yielded very large numbers of viable lactobacilli (109 per gm), representing at least three different morphological types. In contrast, it contained only few enterococci and Gram-negative bacilli (less than 106 per gm). Moreover, E. coli, Proteus sp., and Pseudomonas sp. could not be recovered from the stools under normal conditions. NCS mice proved resistant to the lethal effect of endotoxins. These characteristics of the NCS colony prevailed whether the animals were housed continuously in individual cages on wire grids, or grouped continuously in large cages with wood shavings as litter. However, the composition of the bacterial flora could be rapidly and profoundly altered by a variety of unrelated disturbances such as sudden changes in environmental temperature, crowding in cages, handling of the animals, administration of antibacterial drugs, etc. The first effect of the change was a marked decrease in the numbers of lactobacilli and commonly an increase in the numbers of Gram-negative bacilli and enterococci. When tested 3 weeks after these disturbances some NCS animals were found to have become susceptible to the lethal effects of endotoxin.

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  • Different types of psychological stressors modulate the composition and total biomass of the enteric microbiota in both adult and newborn animals.

    “Different types of psychological stressors modulate the composition and total biomass of the enteric microbiota in both adult15 and newborn animals.16”

    From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [15]

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Authors
Schaedler, R. W., & Dubos, R. J.
Affiliations
Rockefeller University (US)
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
1962-06-01
Volume
115
Issue
6
Pages
1149-1160
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.115.6.1149
PMC
PMC2137400
OpenAlex
W2084581006
Cited by
143
References
13
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 5 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 3 · 2012: 3
FWCI
3.98
Type
journal article
Language
en
Open access
Locations
  • The Journal of Experimental Medicine (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
Keywords
fecal microbiota, mouse strains, lactobacilli, Enterococcus, Gram-negative bacilli, Escherichia coli, Proteus, Pseudomonas, bacterial colonization, environmental disturbance, antibiotic effects on gut microbiota, endotoxic shock
MeSH terms
Animals, Bacteria, Endotoxins, Escherichia coli, Feces, Gram-Negative Bacteria, Immunity, Mice

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