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COMMON INDIVIDUAL ANTIGENIC DETERMINANTS IN FIVE OF EIGHT BALB/c I G A MYELOMA PROTEINS THAT BIND PHOSPHORYL CHOLINE
Open accessAbstract
Eight IgA myeloma proteins derived from independently induced plasma-cytomas in genetically similar inbred BALB/c mice are functionally related by their binding of phosphoryl choline-containing antigens (Pneumococcus C polysaccharide or Lactobacillus antigen). Each protein resembles a single species of immunoglobulin in antibody. The proteins are characterized by highly sensitive myeloma-specific antisera prepared by immunizing mice of other inbred strains with the BALB/c myeloma proteins. Individual or myeloma-specific determinants located on Fab fragments were found on three of the proteins that were unique for that protein and did not react with any other IgA protein among over 70 tested. Remarkably, five of the proteins shared two common myeloma-specific determinants which were specific for this group of five proteins. These results suggest that the five functionally and genetically related proteins sharing the same myeloma-specific determinants might also be structurally similar.
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Cited by
Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities
Xu, J. L., & Davis, M. M. (2000) · Immunity · doi:10.1016/s1074-7613(00)00006-6 · Cited by 779
Innate sensing of oxidation-specific epitopes in health and disease
Binder, C. J., Papac-Milicevic, N., & Witztum, J. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.63 · Cited by 403
The Induction of Meningeal Inflammation by Components of the Pneumococcal Cell Wall
Tuomanen, E., Liu, H., Hengstler, B., Zak, O., & Tomasz, A. (1985) · Journal of Infectious Diseases · doi:10.1093/infdis/151.5.859 · Cited by 355
Höltje, J. V., & Tomasz, A. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41160-5 · Cited by 131
Metadata
- Authors
- Potter, M., & Lieberman, R.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1970-10-01
- Volume
- 132
- Issue
- 4
- Pages
- 737-751
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1966216519
- Cited by
- 245
- References
- 0
- FWCI
- 40.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: COMMON INDIVIDUAL ANTIGENIC DETERMINANTS IN FIVE OF EIGHT BALB/c I G A MYELOMA PROTEINS THAT BIND PHOSPHORYL CHOLINE. https://app.cochat.ai/papers/10.1084/jem.132.4.737
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- Potter, M., & Lieberman, R. (1970). COMMON INDIVIDUAL ANTIGENIC DETERMINANTS IN FIVE OF EIGHT BALB/c I G A MYELOMA PROTEINS THAT BIND PHOSPHORYL CHOLINE. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.132.4.737
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