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Cited by 245

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COMMON INDIVIDUAL ANTIGENIC DETERMINANTS IN FIVE OF EIGHT BALB/c I G A MYELOMA PROTEINS THAT BIND PHOSPHORYL CHOLINE

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Potter, Michael, Lieberman, Rose·1970·The Journal of Experimental Medicine

Abstract

Eight IgA myeloma proteins derived from independently induced plasma-cytomas in genetically similar inbred BALB/c mice are functionally related by their binding of phosphoryl choline-containing antigens (Pneumococcus C polysaccharide or Lactobacillus antigen). Each protein resembles a single species of immunoglobulin in antibody. The proteins are characterized by highly sensitive myeloma-specific antisera prepared by immunizing mice of other inbred strains with the BALB/c myeloma proteins. Individual or myeloma-specific determinants located on Fab fragments were found on three of the proteins that were unique for that protein and did not react with any other IgA protein among over 70 tested. Remarkably, five of the proteins shared two common myeloma-specific determinants which were specific for this group of five proteins. These results suggest that the five functionally and genetically related proteins sharing the same myeloma-specific determinants might also be structurally similar.

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Metadata

Authors
Potter, M., & Lieberman, R.
Venue
The Journal of Experimental Medicine
Published
1970-10-01
Volume
132
Issue
4
Pages
737-751
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
OpenAlex
W1966216519
Cited by
245
References
0
FWCI
40.22
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: COMMON INDIVIDUAL ANTIGENIC DETERMINANTS IN FIVE OF EIGHT BALB/c I G A MYELOMA PROTEINS THAT BIND PHOSPHORYL CHOLINE. https://app.cochat.ai/papers/10.1084/jem.132.4.737
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Potter, M., & Lieberman, R. (1970). COMMON INDIVIDUAL ANTIGENIC DETERMINANTS IN FIVE OF EIGHT BALB/c I G A MYELOMA PROTEINS THAT BIND PHOSPHORYL CHOLINE. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.132.4.737

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.