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THE PHLOGISTIC ROLE OF C3 LEUKOTACTIC FRAGMENTS IN MYOCARDIAL INFARCTS OF RATS
Open accessAbstract
An improved method is described for extraction from rat myocardium of an enzyme that cleaves the third component of complement (C3) into leukotactic fragments. Direct cleavage of C3 has been shown by the use of a radiolabeled preparation of human C3. The enzyme elutes slightly beyond (retarded to) an albumin marker in gel filtration. After surgical ligation of a coronary artery, leukotactic activity can be extracted from infarcted rat myocardium. Described in terms of its time of appearance in infarcted tissue, the leukotactic activity has been identified as cleavage products of rat C3. The C3 fragments are of low molecular weight and heterogenous in size. Rats, if treated with the C3 inactivator (isolated from cobra venom) so as to ablate serum C3, fail to develop leukotactic activity in the infarcted myocardium. In turn, few if any of the usual intense accumulations of neutrophils in response to infected myocardium are seen during the first 48 hr after coronary artery ligation. These studies suggest a nonimmunologic role for C3 in the mediation of the acute inflammatory response in nonspecific tissue injury.
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Citations
Cited by
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Rock, K. L., & Kono, H. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.151456 · Cited by 912
Griselli, M., Herbert, J., Hutchinson, W. L., Taylor, K. M., Sohail, M., Krausz, T., & Pepys, M. B. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.12.1733 · Cited by 508
Role of leukocytes in response to acute myocardial ischemia and reflow in dogs
Engler, R. L., Dahlgren, M. D., Morris, D. D., Peterson, M. A., & Schmid-Schonbein, G. W. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.251.2.h314 · Cited by 507
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Metadata
- Authors
- Hill, J. H., & Ward, P. A.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1971-04-01
- Volume
- 133
- Issue
- 4
- Pages
- 885-900
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2044615120
- Cited by
- 395
- References
- 0
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: THE PHLOGISTIC ROLE OF C3 LEUKOTACTIC FRAGMENTS IN MYOCARDIAL INFARCTS OF RATS. https://app.cochat.ai/papers/10.1084/jem.133.4.885
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- Hill, J. H., & Ward, P. A. (1971). THE PHLOGISTIC ROLE OF C3 LEUKOTACTIC FRAGMENTS IN MYOCARDIAL INFARCTS OF RATS. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.133.4.885
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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