The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Evolutionary conflicts between viruses and restriction factors shape immunity
Open accessAbstract
Host restriction factors are potent, widely expressed intracellular blocks to viral replication that are an important component of the innate immune response to viral infection. However, viruses have evolved mechanisms that antagonize restriction factors. Through evolutionary pressure for both host survival and virus replication, an evolutionary 'arms race' has developed that drives continuous rounds of selection for beneficial mutations in the genes encoding restriction factors and their viral antagonists. Because viruses can evolve faster than their hosts, the innate immune system of modern-day vertebrates is for the most part optimized to defend against ancient viruses, rather than newer viral threats. Thus, the evolutionary history of restriction factors might, in part, explain why humans are susceptible or resistant to the viruses present in the modern world.
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Citations
Cites
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“In addition, the antiviral activity of restriction factors is sometimes specific to families of viruses.”
BackgroundInfluentialThe genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation
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Cited by
Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
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IFITM Proteins Incorporated into HIV-1 Virions Impair Viral Fusion and Spread
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Dual host–virus arms races shape an essential housekeeping protein
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Metadata
- Authors
- Duggal, N. K., & Emerman, M.
- Venue
- Nature Reviews Immunology
- Published
- 2012-09-14
- Volume
- 12
- Issue
- 10
- Pages
- 687-695
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1996463917
- Cited by
- 366
- References
- 9
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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