The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Lipidomics: a global approach to lipid analysis in biological systems
Open accessAbstract
Lipids are water-insoluble molecules that have a wide variety of functions within cells, including: 1) maintenance of electrochemical gradients; 2) subcellular partitioning; 3) first- and second-messenger cell signaling; 4) energy storage; and 5) protein trafficking and membrane anchoring. The physiological importance of lipids is illustrated by the numerous diseases to which lipid abnormalities contribute, including atherosclerosis, diabetes, obesity, and Alzheimer's disease. Lipidomics, a branch of metabolomics, is a systems-based study of all lipids, the molecules with which they interact, and their function within the cell. Recent advances in soft-ionization mass spectrometry, combined with established separation techniques, have allowed the rapid and sensitive detection of a variety of lipid species with minimal sample preparation. A "lipid profile" from a crude lipid extract is a mass spectrum of the composition and abundance of the lipids it contains, which can be used to monitor changes over time and in response to particular stimuli. Lipidomics, integrated with genomics, proteomics, and metabolomics, will contribute toward understanding how lipids function in a biological system and will provide a powerful tool for elucidating the mechanism of lipid-based disease, for biomarker screening, and for monitoring pharmacologic therapy.
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Cites
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Cited by
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
Gieger, C., Geistlinger, L., Altmaier, E., Hrabé de Angelis, M., Kronenberg, F., Meitinger, T., Mewes, H.-W., Wichmann, H.-E., Weinberger, K. M., Adamski, J., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000282 · Cited by 737
Orešič, M., Simell, S., Sysi-Aho, M., Näntö-Salonen, K., Seppänen-Laakso, T., Parikka, V., Katajamaa, M., Hekkala, A., Mattila, I., Keskinen, P., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081800 · Cited by 449
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Jenab, M., Slimani, N., Bictash, M., Ferrari, P., & Bingham, S. A. (2009) · Human Genetics · doi:10.1007/s00439-009-0662-5 · Cited by 448
In vivo lipidomics using single-cell Raman spectroscopy
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“Lipid content within microalgae, as in the general field of lipidomics (8, 9), is commonly analyzed by using solvent extraction–based methodologies, with the lipids subsequently quantified gravimetrically (10–12).”
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Self-citation
Metadata
- Authors
- Watson, A. D.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 47
- Issue
- 10
- Pages
- 2101-2111
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2110658722
- Cited by
- 455
- References
- 102
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Watson, A. D. (2006). Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Lipidomics: a global approach to lipid analysis in biological systems. Journal of Lipid Research. https://doi.org/10.1194/jlr.r600022-jlr200
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