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PROMOTION OF REPLICATION IN LYMPHOID CELLS BY SPECIFIC THIOLS AND DISULFIDES IN VITRO
Open accessAbstract
Numerous lines of mouse lymphoid tumors (13 of 22 tested) showed, with increased sensitivity, a property of normal mouse splenic lymphocytes, the potential for growth promotion in vitro by specific thiols added to standard culture media. For lymphoma L1210 (V), structure activity relationships were examined; 9 of 30 thiols promoted growth; the most active was α-thioglycerol, effective at 0.2 µM. Thiols became oxidized under conditions of tissue culture and had half-lives of less than 8 h. Disulfides of active thiols promoted growth of lymphoma cells. The mitogenic response of splenic lymphocytes to lectins was increased by thiols-disulfides which promoted the growth of lymphoma cells, but the response varied with the mitogen preparation used and under some conditions thiols-disulfides were inhibitory.
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Citations
Cited by
Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587
Age Influence on the Immune System
Makinodan, T., & Kay, M. M. B. (1980) · Advances in Immunology · doi:10.1016/s0065-2776(08)60047-4 · Cited by 699
Gout, P., Buckley, A., Simms, C., & Bruchovsky, N. (2001) · Leukemia · doi:10.1038/sj.leu.2402238 · Cited by 640
GENERATION OF CYTOTOXIC T LYMPHOCYTES IN VITRO
Cerottini, J.-C., Engers, H. D., MacDonald, H. R., & Brunner, K. T. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.140.3.703 · Cited by 478
Transport of cystine and cysteine in mammalian cells
Bannai, S. (1984) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(84)90014-5 · Cited by 329
Metadata
- Authors
- Broome, J. D., & Jeng, M. W.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1973-09-01
- Volume
- 138
- Issue
- 3
- Pages
- 574-592
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2040749622
- Cited by
- 219
- References
- 0
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: PROMOTION OF REPLICATION IN LYMPHOID CELLS BY SPECIFIC THIOLS AND DISULFIDES IN VITRO. https://app.cochat.ai/papers/10.1084/jem.138.3.574
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- Broome, J. D., & Jeng, M. W. (1973). PROMOTION OF REPLICATION IN LYMPHOID CELLS BY SPECIFIC THIOLS AND DISULFIDES IN VITRO. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.138.3.574
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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