The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus.
Open accessAbstract
Maximal cell-mediated lysis of targets infected with lymphocytic choriomeningitis virus occurs only within a H-2 compatible system. Syngeneic immune spleen cells are at least 100 times as effective as are allogeneic lymphocytes. Reciprocal restriction of cytotoxic T-cell activity has been shown to operative between H-2k, H-2d, and H-2b. Experiments with cogenic mice have localized the effect to the H-2 gene complex. Furthermore, the observation that lymphocytes from H-2a mice cause high specific 51Cr release from either H-2d virus-infected cells, indicates that identity at either the K or the D end of the H-2 gene complex is sufficient for this lytic interaction.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
ZINKERNAGEL, R. M., & DOHERTY, P. C. (1974) · Nature · doi:10.1038/248701a0 · Cited by 2,095
Self-citationCell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity
Cerottini, J.-C., & Brunner, K. T. (1974) · Advances in Immunology · doi:10.1016/s0065-2776(08)60308-9 · Cited by 1,141
FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES
Rosenthal, A. S., & Shevach, E. M. (1973) · The Journal of Experimental Medicine · doi:10.1084/jem.138.5.1194 · Cited by 1,036
ZINKERNAGEL, R. M., & DOHERTY, P. C. (1974) · Nature · doi:10.1038/251547a0 · Cited by 853
Self-citationShreffler, D. C., & David, C. S. (1975) · Advances in immunology · doi:10.1016/s0065-2776(08)60208-4 · Cited by 761
Cell‐mediated cytotoxicity to trinitrophenyl‐modified syngeneic lymphocytes
Shearer, G. M. (1974) · European Journal of Immunology · doi:10.1002/eji.1830040802 · Cited by 570
Evolutionary Significance of the HL-A System
BODMER, W. F. (1972) · Nature · doi:10.1038/237139a0 · Cited by 515
Pernis, B., Chiappino, G., Kelus, A. S., & Gell, P. G. H. (1965) · The Journal of Experimental Medicine · doi:10.1084/jem.122.5.853 · Cited by 436
CELL INTERACTIONS BETWEEN HISTOINCOMPATIBLE T AND B LYMPHOCYTES
Katz, D. H., Hamaoka, T., & Benacerraf, B. (1973) · The Journal of Experimental Medicine · doi:10.1084/jem.137.6.1405 · Cited by 428
T‐Cell‐Mediated Immunopathology in Viral Infections
Doherty, P. C., & Zinkernagel, R. M. (1974) · Immunological Reviews · doi:10.1111/j.1600-065x.1974.tb00129.x · Cited by 284
Self-citation
Cited by
Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids
Salter, R. D., Howell, D. N., & Cresswell, P. (1985) · Immunogenetics · doi:10.1007/bf00375376 · Cited by 566
Morrison, L. A., Lukacher, A. E., Braciale, V. L., Fan, D. P., & Braciale, T. J. (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.4.903 · Cited by 507
A BIOLOGICAL ROLE FOR THE MAJOR HISTOCOMPATIBILITY ANTIGENS
Doherty, P. C., & Zinkernagel, R. M. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92610-0 · Cited by 492
Self-citationAndersson, M. (1985) · Cell · doi:10.1016/0092-8674(85)90026-1 · Cited by 323
The discovery of MHC restriction
Zinkernagel, R. M., & Doherty, P. C. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)80008-4 · Cited by 287
Self-citation
Metadata
- Authors
- Doherty, P. C., & Zinkernagel, R. M.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1975-02-01
- Volume
- 141
- Issue
- 2
- Pages
- 502-507
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2097169892
- Cited by
- 366
- References
- 17
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. https://app.cochat.ai/papers/10.1084/jem.141.2.502
- The paper
- Doherty, P. C., & Zinkernagel, R. M. (1975). H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. The Journal of experimental medicine. https://doi.org/10.1084/jem.141.2.502
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
