Matrigel: Basement membrane matrix with biological activity

Feeder-free growth of undifferentiated human embryonic stem cells

Xu, C., Inokuma, M. S., Denham, J., Golds, K., Kundu, P., Gold, J. D., & Carpenter, M. K. (2001) · Nature Biotechnology · doi:10.1038/nbt1001-971 · Cited by 1,872 · see citing works

Laminin–a glycoprotein from basement membranes

Timpl, R., Rohde, H., Robey, P. G., Rennard, S. I., Foidart, J. M., & Martin, G. R. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83607-4 · Cited by 1,780 · see citing works

A rapid in vitro assay for quantitating the invasive potential of tumor cells.

Albini, A., Iwamoto, Y., Hk, K., Gr, M., Aaronson, S. A., Jm, K., & McEwan, R. N. (1987) · PubMed · Cited by 1,769 · see citing works

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.

Kubota, Y., Kleinman, H. K., Martin, G. R., & Lawley, T. J. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.4.1589 · Cited by 1,210 · see citing works

Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

Klement, G. L., Baruchel, S., Rak, J. W., Man, S., Clark, K., Hicklin, D. J., Böhlen, P., & Kerbel, R. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8829 · Cited by 1,166 · see citing works

Basement membrane complexes with biological activity

Kleinman, H. K., McGarvey, M. L., Hassell, J. R., Star, V. L., Cannon, F. B., Laurie, G. W., & Martin, G. R. (1986) · Biochemistry · doi:10.1021/bi00350a005 · Cited by 1,164 · see citing works

Control of adhesion-dependent cell survival by focal adhesion kinase.

Frisch, S. M., Vuori, K., Ruoslahti, E. I., & Chan-Hui, P.-Y. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.3.793 · Cited by 1,111 · see citing works

Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice

Hanahan, D., Bergers, G., & Bergsland, E. K. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9872 · Cited by 868 · see citing works

Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation

Asakura, A., Rudnicki, M. A., & Komaki, M. (2001) · Differentiation · doi:10.1046/j.1432-0436.2001.680412.x · Cited by 839 · see citing works

A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor.

Passaniti, A., Taylor, R. M., Пили, Р., Guo, Y., Long, P., Haney, J. A., Pauly, R. R., Grant, D. S., & Martin, G. R. (1992) · PubMed · Cited by 800 · see citing works

Angiogenesis Assays: A Critical Overview

Auerbach, R., Lewis, R. L., Shinners, B., Kubai, L., & Akhtar, N. (2003) · Clinical Chemistry · doi:10.1373/49.1.32 · Cited by 705 · see citing works

Identification of multiple active growth factors in basement membrane matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components

Vukicevic, S., Kleinman, H. K., Luyten, F. P., Roberts, A. B., Roche, N. S., & Reddi, A. H. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90397-q · Cited by 696 · see citing works

Isolation of a heparan sulfate-containing proteoglycan from basement membrane.

Hassell, J. R., Robey, P. G., Barrach, H.-J., Wilczek, J., Rennard, S. I., & Martin, G. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.8.4494 · Cited by 674 · see citing works

<i>In vitro</i> cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis

Sekiya, I., Vuoristo, J. T., Larson, B. L., & Prockop, D. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052716199 · Cited by 648 · see citing works

A murine tumor producing a matrix of basement membrane.

Orkin, R. W., Gehron, P., McGoodwin, E. B., Martin, G. R., Valentine, T., & Swarm, R. L. (1977) · The Journal of Experimental Medicine · doi:10.1084/jem.145.1.204 · Cited by 633 · see citing works

Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells.

Ml, L., Aggeler, J., Farson, D. A., Hatier, C., Hassell, J. R., & Bissell, M. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.1.136 · Cited by 620 · see citing works

Extracellular matrix regulates Sertoli cell differentiation, testicular cord formation, and germ cell development in vitro.

Hadley, M. A., Byers, S. W., Suarez‐Quian, C. A., Kleinman, H. K., & Dym, M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.4.1511 · Cited by 539 · see citing works

Role of the extracellular matrix in morphogenesis

Kleinman, H. K., Philp, D., & Hoffman, M. P. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.08.002 · Cited by 484 · see citing works

Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

Schuetz, E. G., Li, D., Omiecinski, C. J., Müller‐Eberhard, U., Kleinman, H. K., Elswick, B. A., & Guzelian, P. S. (1988) · Journal of Cellular Physiology · doi:10.1002/jcp.1041340302 · Cited by 465 · see citing works

Biochemistry and Metabolism of Basement Membranes

Kefalides, N. A., Alper, R., & Clark, C. C. (1979) · International review of cytology · doi:10.1016/s0074-7696(08)61998-1 · Cited by 464 · see citing works

Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor.

Liotta, L. A., Abe, S., Robey, P. G., et al. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.5.2268 · Cited by 453 · see citing works

The complete sequence of perlecan, a basement membrane heparan sulfate proteoglycan, reveals extensive similarity with laminin A chain, low density lipoprotein-receptor, and the neural cell adhesion molecule.

Noonan, D. M., Fulle, A., Valente, P., Cai, S., Horigan, E. A., Sasaki, M., Yamada, Y., & Hassell, J. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54445-8 · Cited by 450 · see citing works

Nature of the Collagenous Protein in a Tumor Basement Membrane

Timpl, R., Martin, G. R., Brückner, P., et al. (1978) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1978.tb12139.x · Cited by 334 · see citing works

Nature of the collagen synthesized by a transplanted chondrosarcoma

Smith, B. D., Martin, G. R., Miller, E. J., et al. (1975) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(75)90378-1 · Cited by 244 · see citing works

Embryonic stem cell differentiation: The role of extracellular factors

Czyż, J., & Wobus, A. M. (2001) · Differentiation · doi:10.1046/j.1432-0436.2001.680404.x · Cited by 243 · see citing works

Epidermal growth factor or transforming growth factor alpha is required for kidney tubulogenesis in matrigel cultures in serum-free medium.

Taub, M. L., Wang, Y., Szczesny, T., & Kleinman, H. K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.4002 · Cited by 241 · see citing works

The basement membrane matrix in malignancy

Engbring, J. A., & Kleinman, H. K. (2003) · The Journal of Pathology · doi:10.1002/path.1396 · Cited by 235 · see citing works

Modulation of microvascular growth and morphogenesis by reconstituted basement membrane gel in three-dimensional cultures of rat aorta: A comparative study of angiogenesis in Matrigel, collagen, fibrin, and plasma clot

Nicosia, R. F., & Ottinetti, A. (1990) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02624102 · Cited by 223 · see citing works

Localization of binding sites for laminin, heparan sulfate proteoglycan and fibronectin on basement membrane (type IV) collagen

Laurie, G. W., Bing, J.-T., Kleinman, H. K., et al. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90391-8 · Cited by 215 · see citing works

Enhanced Tumor Growth of Both Primary and Established Human and Murine Tumor Cells in Athymic Mice After Coinjection With Matrigel

Fridman, R., Kibbey, M. C., Royce, L. S., Zain, M., Sweeney, T. M., Jicha, D. L., Yannelli, J. R., Martin, G. R., & Kleinman, H. K. (1991) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/83.11.769 · Cited by 205 · see citing works

Differentiation of canalicular cell processes in bone cells by basement membrane matrix components: Regulation by discrete domains of laminin

Vukičević, S., Luyten, F. P., Kleinman, H. K., & Reddi, A. H. (1990) · Cell · doi:10.1016/0092-8674(90)90176-f · Cited by 202 · see citing works

Complex Extracellular Matrices Promote Tissue‐Specific Stem Cell Differentiation

Philp, D., Chen, S. S., Fitzgerald, W., Orenstein, J. O., Margolis, L. B., & Kleinman, H. K. (2005) · Stem Cells · doi:10.1634/stemcells.2002-0109 · Cited by 173 · see citing works

Transplantation of human prostatic carcinoma into nude mice in Matrigel.

Pretlow, T. G., Delmoro, C. M., Dilley, G. G., et al. (1991) · PubMed · Cited by 162 · see citing works

Invasion of reconstituted basement membrane matrix by metastatic human tumor cells.

Kramer, R. H., Bensch, K. G., & Wong, J. (1986) · PubMed · Cited by 158 · see citing works

Role of laminin-1 and TGF-β3 in acinar differentiation of a human submandibular gland cell line (HSG)

Hoffman, M. P., Kibbey, M. C., Letterio, J. J., et al. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.8.2013 · Cited by 149 · see citing works

Telomerized human microvasculature is functional in vivo

Yang, J., Nagavarapu, U., Relloma, K., Sjaastad, M. D., Moss, W. C., Passaniti, A., & Herron, G. S. (2001) · Nature Biotechnology · doi:10.1038/85655 · Cited by 147 · see citing works

Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts

Noël, A., Pauw-Gillet, M. C. D., Purnell, G., Nusgens, B., LAPIERE, C. H. M., & Foidart, J. M. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.453 · Cited by 142 · see citing works

Altered Angiogenesis Underlying Age-Dependent Changes in Tumor Growth

Пили, Р., Guo, Y., Chang, J., Nakanishi, H., Martin, G. R., & Passaniti, A. (1994) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/86.17.1303 · Cited by 139 · see citing works

Neural crest migration in 3D extracellular matrix utilizes laminin, fibronectin, or collagen

Bilozur, M. E., & Hay, E. D. (1988) · Developmental Biology · doi:10.1016/0012-1606(88)90055-3 · Cited by 133 · see citing works

Acinar differentiation by non-malignant immortalized human prostatic epithelial cells and its loss by malignant cells

Webber, M. (1997) · Carcinogenesis · doi:10.1093/carcin/18.6.1225 · Cited by 131 · see citing works

Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-basedin vitro assays

Bae, S.-N., Arand, G., Azzam, H. S., et al. (1993) · Breast Cancer Research and Treatment · doi:10.1007/bf01833264 · Cited by 122 · see citing works

Schwann cell myelination: induction by exogenous basement membrane-like extracellular matrix.

Carey, D., Todd, M. S., & Rafferty, C. M. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.6.2254 · Cited by 114 · see citing works

Regulation of cell attachment and cell number by fibronectin and laminin

Terranova, V. P., Aumailley, M., Sultan, L. H., Martin, G. R., & Kleinman, H. K. (1986) · Journal of Cellular Physiology · doi:10.1002/jcp.1041270318 · Cited by 110 · see citing works

Light microscopic immunolocalization of type IV collagen, laminin, heparan sulfate proteoglycan, and fibronectin in the basement membranes of a variety of rat organs

Laurie, G. W., Leblond, C. P., & Martin, G. R. (1983) · American Journal of Anatomy · doi:10.1002/aja.1001670107 · Cited by 107 · see citing works

Role of Basement Membranes in Cell Differentiation

Kleinman, H. K., Graf, J., IWAMOTO, Y., et al. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb25004.x · Cited by 99 · see citing works

Identification of Endothelial Cell Binding Sites on the Laminin γ1 Chain

Ponce, M. L., Nomizu, M., Delgado, M. C., Kuratomi, Y., Hoffman, M. P., Powell, S. K., Yamada, Y., Kleinman, H. K., & Malinda, K. M. (1999) · Circulation Research · doi:10.1161/01.res.84.6.688 · Cited by 97 · see citing works

The incubation of laminin, collagen IV, and heparan sulfate proteoglycan at 35 degrees C yields basement membrane-like structures.

Grant, D. S., Leblond, C. P., Kleinman, H. K., Inoué, S., & Hassell, J. R. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.4.1567 · Cited by 88 · see citing works

Effects of extracellular matrix components on the growth and differentiation of cultured rat hepatocytes

Sawada, N., Tomomura, A., Sattler, C. A., Sattler, G. L., Kleinman, H. K., & Pitot, H. C. (1987) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02623709 · Cited by 82 · see citing works

Sporogonic Development of a Malaria Parasite in Vitro

Warburg, A., & Miller, L. H. (1992) · Science · doi:10.1126/science.1734521 · Cited by 74 · see citing works

Biological Response of Chondrocytes to Hydrogels

Elisseeff, J. H., LEE, A., Kleinman, H. K., & YAMADA, Y. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb03062.x · Cited by 55 · see citing works

Molecular Basis of Constitutive Production of Basement Membrane Components

Futaki, S., Hayashi, Y., Yamashita, M., Yagi, K., Bono, H., Hayashizaki, Y., Okazaki, Y., & Sekiguchi, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304985200 · Cited by 52 · see citing works

Modulation of murine B16F10 melanoma plasminogen activator production by a synthetic peptide derived from the laminin A chain.

Stack, M. S., Gray, R. D., & Pizzo, S. V. (1993) · PubMed · Cited by 47 · see citing works

Glandular-like morphogenesis of the human submandibular tumor cell line A253 on basement membrane components

Kibeey, M. C., Royce, L. S., Dym, M., et al. (1992) · Experimental Cell Research · doi:10.1016/0014-4827(92)90389-p · Cited by 44 · see citing works

Advanced therapy of prostate disease

Resnick, E. B. M. I., & Thompson, I. M. (2000) · Cited by 39 · see citing works

Mesenchymal cell chondrogenesis is stimulated by basement membrane matrix and inhibited by age-associated factors

Bradham, D. M., Passaniti, A., & Horton, W. E. (1995) · Matrix Biology · doi:10.1016/s0945-053x(05)80005-8 · Cited by 34 · see citing works

Models of prostate cancer

Albanese, C., Rodriguez, O. C., Johnson, M. D., & Fricke, S. T. (2005) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2005.05.002 · Cited by 13 · see citing works

Culture of Parotid Acinar Cells on a Reconstituted Basement Membrane Substratum

Oliver, C., Waters, J. F., Tolbert, C., et al. (1987) · Journal of Dental Research · doi:10.1177/00220345870660023901 · Cited by 12 · see citing works

The extracellular matrix at a glance

Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.023820 · Cited by 4,334 · see citing works

A practical guide to hydrogels for cell culture

Caliari, S. R., & Burdick, J. A. (2016) · Nature Methods · doi:10.1038/nmeth.3839 · Cited by 2,075 · see citing works

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

Baker, B. M., & Chen, C. S. (2012) · Journal of Cell Science · doi:10.1242/jcs.079509 · Cited by 1,760 · see citing works

Three-dimensional in vitro cell culture models in drug discovery and drug repositioning

Langhans, S. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00006 · Cited by 1,522 · see citing works

Matrigel: A complex protein mixture required for optimal growth of cell culture

Hughes, C. S., Postovit, L. M., & Lajoie, G. A. (2010) · PROTEOMICS · doi:10.1002/pmic.200900758 · Cited by 1,534 · see citing works

2D and 3D Cell Cultures - a Comparison of Different Types of Cancer Cell Cultures

Kapałczyńska, M., Kolenda, T., Przybyła, W., Zajączkowska, M., Teresiak, A., Filas, V., Ibbs, M., Bliźniak, R., Łuczewski, Ł., & Lamperska, K. (2016) · Archives of Medical Science · doi:10.5114/aoms.2016.63743 · Cited by 1,499 · see citing works

Designer matrices for intestinal stem cell and organoid culture

Gjorevski, N., Sachs, N., Manfrin, A., Giger, S., Bragina, M. E., Ordóñez-Morán, P., Clevers, H., & Lutolf, M. P. (2016) · Nature · doi:10.1038/nature20168 · Cited by 1,426 · see citing works

Three-dimensional culture models of normal and malignant breast epithelial cells

Lee, G. Y., Kenny, P. A., Lee, E. H., & Bissell, M. J. (2007) · Nature Methods · doi:10.1038/nmeth1015 · Cited by 1,336 · see citing works

Three-dimensional cell culture: the missing link in drug discovery

Breslin, S., & O’Driscoll, L. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2012.10.003 · Cited by 1,332 · see citing works

Engineering organoids

Hofer, M., & Lutolf, M. P. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00279-y · Cited by 1,184 · see citing works

Three-Dimensional Cell Culture Matrices: State of the Art

Lee, J., Cuddihy, M. J., & Kotov, N. A. (2008) · Tissue Engineering Part B: Reviews · doi:10.1089/teb.2007.0150 · Cited by 1,047 · see citing works

Synthetic alternatives to Matrigel

Aisenbrey, E. A., & Murphy, W. L. (2020) · Nature Reviews Materials · doi:10.1038/s41578-020-0199-8 · Cited by 1,016 · see citing works

Functionalization, preparation and use of cell-laden gelatin methacryloyl–based hydrogels as modular tissue culture platforms

Loessner, D., Meinert, C., Kaemmerer, E., Martine, L. C., Yue, K., Levett, P. A., Klein, T. J., Melchels, F. P. W., Khademhosseini, A., & Hutmacher, D. W. (2016) · Nature Protocols · doi:10.1038/nprot.2016.037 · Cited by 868 · see citing works

Extracellular matrix-based materials for regenerative medicine

Hussey, G. S., Dziki, J. L., & Badylak, S. F. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0023-x · Cited by 844 · see citing works

In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract

Arnaoutova, I., & Kleinman, H. K. (2010) · Nature Protocols · doi:10.1038/nprot.2010.6 · Cited by 760 · see citing works

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

Loessner, D., Stok, K. S., Lutolf, M. P., Hutmacher, D. W., Clements, J. A., & Rizzi, S. C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.064 · Cited by 602 · see citing works

Halfway between 2D and Animal Models: Are 3D Cultures the Ideal Tool to Study Cancer-Microenvironment Interactions?

Hoarau-Véchot, J., Rafii, A., Touboul, C., & Pasquier, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010181 · Cited by 489 · see citing works

Matrigel: From discovery and ECM mimicry to assays and models for cancer research

Benton, G., Arnaoutova, I., George, J., Kleinman, H. K., & Koblinski, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.06.005 · Cited by 477 · see citing works

Towards organoid culture without Matrigel

Kozlowski, M. T., Crook, C. J., & Ku, H. T. (2021) · Communications Biology · doi:10.1038/s42003-021-02910-8 · Cited by 409 · see citing works

Animal models of age related macular degeneration

Pennesi, M. E., Neuringer, M., & Courtney, R. J. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.06.003 · Cited by 391 · see citing works

Engineering cancer microenvironments for in vitro 3-D tumor models

Asghar, W., El Assal, R., Shafiee, H., Pitteri, S., Paulmurugan, R., & Demirci, U. (2015) · Materials Today · doi:10.1016/j.mattod.2015.05.002 · Cited by 316 · see citing works

The elastic modulus of Matrigel™ as determined by atomic force microscopy

Soofi, S. S., Last, J. A., Liliensiek, S. J., Nealey, P. F., & Murphy, C. J. (2009) · Journal of Structural Biology · doi:10.1016/j.jsb.2009.05.005 · Cited by 309 · see citing works

Organotypic 3D cell culture models: using the rotating wall vessel to study host–pathogen interactions

Barrila, J., Radtke, A. L., Crabbé, A., Sarker, S. F., Herbst-Kralovetz, M. M., Ott, C. M., & Nickerson, C. A. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2423 · Cited by 302 · see citing works

Engineering Organoid Vascularization

Grebenyuk, S., & Ranga, A. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00039 · Cited by 295 · see citing works

Growth of Epithelial Organoids in a Defined Hydrogel

Broguiere, N., Isenmann, L., Hirt, C., Ringel, T., Placzek, S., Cavalli, E., Ringnalda, F., Villiger, L., Züllig, R., Lehmann, R., et al. (2018) · Advanced Materials · doi:10.1002/adma.201801621 · Cited by 282 · see citing works

3D niche microarrays for systems-level analyses of cell fate

Ranga, A., Gobaa, S., Okawa, Y., Mosiewicz, K., Negro, A., & Lutolf, M. P. (2014) · Nature Communications · doi:10.1038/ncomms5324 · Cited by 238 · see citing works

Gelatine Methacrylamide-Based Hydrogels: An Alternative Three-Dimensional Cancer Cell Culture System

Kaemmerer, E., Melchels, F. P. W., Holzapfel, B. M., Meckel, T., Hutmacher, D. W., & Loessner, D. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.02.035 · Cited by 219 · see citing works

Complex mechanics of the heterogeneous extracellular matrix in cancer

Malandrino, A., Mak, M., Kamm, R. D., & Moeendarbary, E. (2018) · Extreme Mechanics Letters · doi:10.1016/j.eml.2018.02.003 · Cited by 192 · see citing works

Drug discovery through stem cell-based organoid models

Ranga, A., Gjorevski, N., & Lutolf, M. P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.02.006 · Cited by 195 · see citing works

Emerging tumor spheroids technologies for 3D in vitro cancer modeling

Rodrigues, T., Kundu, B., Silva-Correia, J., Kundu, S. C., Oliveira, J. M., Reis, R. L., & Correlo, V. M. (2018) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2017.10.018 · Cited by 178 · see citing works

Regeneration of skin appendages and nerves: current status and further challenges

Weng, T., Wu, P., Zhang, W., Zheng, Y., Li, Q., Jin, R., Chen, H., You, C., Guo, S., Han, C., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02248-5 · Cited by 158 · see citing works

3D bioprinting: improving<i>in vitro</i>models of metastasis with heterogeneous tumor microenvironments

Albritton, J. L., & Miller, J. S. (2017) · Disease Models &amp; Mechanisms · doi:10.1242/dmm.025049 · Cited by 154 · see citing works

Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion

Nguyen, E. H., Daly, W. T., Le, N. N. T., Farnoodian, M., Belair, D. G., Schwartz, M. P., Lebakken, C. S., Ananiev, G. E., Saghiri, M. A., Knudsen, T. B., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0096 · Cited by 136 · see citing works

3D Matrices for Anti-Cancer Drug Testing and Development

Gurski, L. A., Petrelli, N. J., Jia, X., & Farach-Carson, M. C. (2010) · Oncology Issues · doi:10.1080/10463356.2010.11883480 · Cited by 130 · see citing works

Polysaccharide matrices used in 3D in vitro cell culture systems

Diekjürgen, D., & Grainger, D. W. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.020 · Cited by 125 · see citing works

Intestinal organoids containing poly(lactic‐<i>co</i>‐glycolic acid) nanoparticles for the treatment of inflammatory bowel diseases

Davoudi, Z., Peroutka‐Bigus, N., Bellaire, B., Wannemuehler, M., Barrett, T. A., Narasimhan, B., & Wang, Q. (2018) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36305 · Cited by 118 · see citing works

Three-dimensional hyaluronic acid hydrogel-based models for in vitro human iPSC-derived NPC culture and differentiation

Wu, S., Xu, R., Duan, B., & Jiang, P. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00721c · Cited by 111 · see citing works

Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025

Allgayer, H., Mahapatra, S., Mishra, B., Swain, B., Saha, S., Khanra, S., Kumari, K., Panda, V. K., Malhotra, D., Patil, N. S., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02338-2 · Cited by 127 · see citing works

A Cancer Cell Spheroid Assay to Assess Invasion in a 3D Setting

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Microextrusion printing cell-laden networks of type I collagen with patterned fiber alignment and geometry

Nerger, B. A., Brun, P.-T., & Nelson, C. M. (2019) · Soft Matter · doi:10.1039/c8sm02605j · Cited by 111 · see citing works

Micropatterns of Matrigel for three-dimensional epithelial cultures

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Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering?

Schneeberger, K., Spee, B., Costa, P., Sachs, N., Clevers, H., & Malda, J. (2017) · Biofabrication · doi:10.1088/1758-5090/aa6121 · Cited by 100 · see citing works

Hydrogels derived from decellularized liver tissue support the growth and differentiation of cholangiocyte organoids

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Extracellular matrix requirements for gastrointestinal organoid cultures

Rezakhani, S., Gjorevski, N., & Lutolf, M. P. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121020 · Cited by 100 · see citing works

Matrigel improves functional properties of human submandibular salivary gland cell line

Maria, O. M., Maria, O., Liu, Y., Komarova, S. V., & Tran, S. D. (2011) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2011.01.001 · Cited by 82 · see citing works

Matrigel Basement Membrane Matrix influences expression of microRNAs in cancer cell lines

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Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer

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Different astroglia permissivity controls the migration of olfactory bulb interneuron precursors

García‐Marqués, J., De Carlos, J. A., Greer, C. A., & López‐Mascaraque, L. (2010) · Glia · doi:10.1002/glia.20918 · Cited by 46 · see citing works

Constructing biomimetic liver models through biomaterials and vasculature engineering

Lv, W., Zhou, H., Aazmi, A., Yu, M., Xu, X., Yang, H., Huang, Y. Y. S., & Ma, L. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac079 · Cited by 45 · see citing works

Programmable Control in Extracellular Matrix-mimicking Polymer Hydrogels

Hof, K. S., & Bastings, M. M. C. (2017) · CHIMIA · doi:10.2533/chimia.2017.342 · Cited by 11 · see citing works

Colony-Forming Progenitor Cells in the Postnatal Mouse Liver and Pancreas Give Rise to Morphologically Distinct Insulin-Expressing Colonies in 3D Cultures

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Cell proliferation and differentiation during the three dimensional reconstitution of eccrine sweat glands

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The morphologies of breast cancer cell lines in three‐dimensional assays correlate with their profiles of gene expression

Kenny, P. A., Lee, G. Y., Myers, C. A., Neve, R. M., Semeiks, J. R., Spellman, P. T., Lorenz, K., Lee, E. H., Barcellos-Hoff, M. H., Petersen, O. W., et al. (2007) · Molecular Oncology · doi:10.1016/j.molonc.2007.02.004 · Cited by 2 · see citing works

Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays

Spänle, J. V., Haiber, L. M., & Seeger, B. (2026) · Frontiers in Toxicology · doi:10.3389/ftox.2026.1800157 · Cited by 1 · see citing works

Organ-specific human extracellular matrix materials for 3-dimensional porous scaffolds

Patel, A. N., & Theisen, J. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2015.03.567

Decellularized extracellular matrix hydrogels—cell behavior as a function of matrix stiffness

Sasikumar, S., Chameettachal, S., Cromer, B. A., Pati, F., & Kingshott, P. (2019) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2019.05.002 · Cited by 40 · see citing works

TGF-alpha, EGF, and their cognate EGF receptor are co-expressed with desmin during embryonic, fetal, and neonatal myogenesis in mouse tongue development

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Detection by ELISA of laminin released by endothelial cells from a collagen coated layer of Matrigel

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Chemical decellularization: a promising approach for preparation of extracellular matrix

Hrebíková, H., Diaz, D., & Mokrý, J. (2013) · Biomedical Papers · doi:10.5507/bp.2013.076 · Cited by 53 · see citing works