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An antigen shared by a human T cell subset and B cell chronic lymphocytic leukemic cells. Distribution on normal and malignant lymphoid cells.
Open accessAbstract
We obtained a monoclonal antibody, A50, after immunizing Biozzi's high responder strain of mice with T cell chronic lymphocytic leukemia (T-CLL) cells. A50 recognized an antigen present on the surface of B cell chronic lymphocytic leukemia cells from many patients and from cells of T lineage from any subject we tested. We could not find this antigen either on the surface of normal B cell or on other non-T cell malignancies. On T cells, this antigen was present on a subpopulation of thymus cells, and on most peripheral T cells. The antigen was present on the surface of cells from T-CLL, Sézary's disease, and a subset o T cell lymphoma. The antigen seemed to belong to a complex set of antigenic determinants that we had defined with rabbit antisera.
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Citations
Cited by
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Rurik, J. G., Tombácz, I., Yadegari, A., Méndez Fernández, P. O., Shewale, S. V., Li, L., Kimura, T., Soliman, O. Y., Papp, T. E., Tam, Y. K., et al. (2022) · Science · doi:10.1126/science.abm0594 · Cited by 1,400
Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia.
Caligaris-Cappio, F., Gobbi, M., Bofill, M., & Janossy, G. (1982) · The Journal of experimental medicine · doi:10.1084/jem.155.2.623 · Cited by 469
Haynes, B. F., Metzgar, R. S., Minna, J. D., & Bunn, P. A. (1981) · New England Journal of Medicine · doi:10.1056/nejm198105283042202 · Cited by 334
Kipps, T. J. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60663-x · Cited by 321
Sthoeger, Z. M., Wakai, M., Tse, D. B., Vinciguerra, V. P., Allen, S. L., Budman, D. R., Lichtman, S. M., Schulman, P., Weiselberg, L. R., & Chiorazzi, N. (1989) · The Journal of experimental medicine · doi:10.1084/jem.169.1.255 · Cited by 285
Metadata
- Authors
- Boumsell, L., Coppin, H., Pham, D., Raynal, B., Lemerle, J., Dausset, J., & Bernard, A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1980-07-01
- Volume
- 152
- Issue
- 1
- Pages
- 229-234
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2104303839
- Cited by
- 186
- References
- 0
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Boumsell, L., Coppin, H., Pham, D., Raynal, B., Lemerle, J., Dausset, J., & Bernard, A. (1980). An antigen shared by a human T cell subset and B cell chronic lymphocytic leukemic cells. Distribution on normal and malignant lymphoid cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.152.1.229
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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