The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Phenotypic Characterization of Cutaneous T-Cell Lymphoma: Use of Monoclonal Antibodies to Compare with Other Malignant T Cells
Abstract
We studied the surface-antigen pattern of T cells in peripheral blood and cell lines from patients with advanced cutaneous T-cell lymphoma (CTCL) or T-cell acute lymphoblastic leukemia. The antigen patterns of cutaneous T-cell lymphoma cells from peripheral blood and established cell lines were nearly identical; the cells were negative for human thymus antigen (OKT6 and NA1/34), positive for pan-T-cell (OKT3, 17F12, 10.2, and 9.6) and helper-T-cell-subset (OKT4) antigens, and negative for T-cell-subset antigens 3A1 and OKT8. In contrast, the phenotypes of malignant T cells from patients with acute lymphoblastic leukemia were heterogeneous, with at least five patterns of reactivity. The T-cell-specific antibody 3A1 was the only monoclonal reagent that clearly distinguished the peripheral-blood T cells in CTCL (3A1-) from those in acute lymphoblastic leukemia (3A1+). Moreover, 3A1 was the most reliable T-cell marker in acute lymphoblastic leukemia. We conclude that circulating CTCL (Sézary) T cells are homogeneous in their antigen phenotype and are derived from a well-differentiated 3A1-, OKT4+, OKT8- helper-T-cell subset.
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Citations
Cites
Continuous cultures of fused cells secreting antibody of predefined specificity
KÖHLER, G., & MILSTEIN, C. (1975) · Nature · doi:10.1038/256495a0 · Cited by 17,229
Reinherz, E. L., Kung, P. C., Goldstein, G., Levey, R. H., & Schlossman, S. F. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1588 · Cited by 1,630
Monoclonal Antibodies Defining Distinctive Human T Cell Surface Antigens
Kung, P. C., Goldstein, G., Reinherz, E. L., & Schlossman, S. F. (1979) · Science · doi:10.1126/science.314668 · Cited by 1,453
Regulation of the Immune Response — Inducer and Suppressor T-Lymphocyte Subsets in Human Beings
Reinherz, E. L., & Schlossman, S. F. (1980) · New England Journal of Medicine · doi:10.1056/nejm198008143030704 · Cited by 724
A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody
McMichael, A. J., Pilch, J. R., Fabre, J. W., Mason, D. Y., Galfré, G., & Milstein, C. (1979) · European Journal of Immunology · doi:10.1002/eji.1830090307 · Cited by 500
The Sézary syndrome: a malignant proliferation of helper T cells.
Broder, S., Edelson, R. L., Lutzner, M. A., Nelson, D. L., MacDermott, R. P., Durm, M. E., Goldman, C. K., Meade, B. D., & Waldmann, T. A. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108585 · Cited by 474
Haynes, B. F., Hemler, M. E., Mann, D. L., Eisenbarth, G. S., Shelhamer, J., Mostowski, H. S., Thomas, C. A., Strominger, J. L., & Fauci, A. S. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.126.4.1409 · Cited by 450
Self-citationMitogen requirements for the in vitro propagation of cutaneous T-cell lymphomas
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Self-citationMonoclonal antibodies identifying a novel T-Cell antigen and Ia antigens of human lymphocytes
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Cited by
Schmidt, D., Goronzy, J. J., & Weyand, C. M. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118638 · Cited by 482
Weiss, L. M., Hu, E., Wood, G. S., Moulds, C., Cleary, M. L., Warnke, R., & Sklar, J. (1985) · New England Journal of Medicine · doi:10.1056/nejm198508293130903 · Cited by 339
Metadata
- Authors
- Haynes, B. F., Metzgar, R. S., Minna, J. D., & Bunn, P. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1981-05-28
- Volume
- 304
- Issue
- 22
- Pages
- 1319-1323
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2337543356
- Cited by
- 334
- References
- 12
- FWCI
- 73.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Haynes, B. F., Metzgar, R. S., Minna, J. D., & Bunn, P. A. (1981). Phenotypic Characterization of Cutaneous T-Cell Lymphoma: Use of Monoclonal Antibodies to Compare with Other Malignant T Cells. New England Journal of Medicine. https://doi.org/10.1056/nejm198105283042202
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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