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Functional analysis of human T cell subsets defined by monoclonal antibodies. IV. Induction of suppressor cells within the OKT4+ population.
Open accessAbstract
In this report, we explored the functional heterogeneity within the OKT4+ subset of human T cells. Evidence was obtained that although in vitro pokeweed mitogen-activated OKT4+ cells can function as radioresistant helper cells, these activated OKT4+ cells could also exert potent feedback suppression. Despite the induction of suppressor cells after pokeweed mitogen activation, the OKT4+ population maintains its original OKT3+, OKT4+, nd OKT8- surface phenotype. The suppressor cells contained within the activated OKT4+ population were found to be radiosensitive. Importantly, the suppression mediated by activated OKT4+ cells required the presence of radiosensitive cells contained within the resting OKT4+ population. Taken together, these results suggest that the OKT4+ subset of human T cells contains cells that can be activated to differentiate into suppressor cells independent of OKT8+ cells.
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Citations
Cited by
The Primary Immunodeficiencies
Rosen, F. S., Cooper, M. D., & Wedgwood, R. J. P. (1984) · New England Journal of Medicine · doi:10.1056/nejm198408023110506 · Cited by 1,077
MADDON, P., LITTMAN, D., GODFREY, M., MADDON, D., CHESS, L., & AXEL, R. (1985) · Cell · doi:10.1016/s0092-8674(85)80105-7 · Cited by 658
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Smith, D. H., Byrn, R. A., Marsters, S. A., Gregory, T., Groopman, J. E., & Capon, D. J. (1987) · Science · doi:10.1126/science.3500514 · Cited by 485
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Stahl, R. E., Friedman-Kien, A., Dubin, R., Marmor, M., & Zolla-Pazner, S. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90174-7 · Cited by 318
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Metadata
- Authors
- Thomas, Y., Rogozinski, L., Irigoyen, O. H., Friedman, S. M., Kung, P. C., Goldstein, G., & Chess, L.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1981-08-01
- Volume
- 154
- Issue
- 2
- Pages
- 459-467
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2111471472
- Cited by
- 243
- References
- 0
- FWCI
- 18.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Thomas, Y., Rogozinski, L., Irigoyen, O. H., Friedman, S. M., Kung, P. C., Goldstein, G., & Chess, L. (1981). Functional analysis of human T cell subsets defined by monoclonal antibodies. IV. Induction of suppressor cells within the OKT4+ population. The Journal of experimental medicine. https://doi.org/10.1084/jem.154.2.459
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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