The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Circumsporozoite proteins of human malaria parasites Plasmodium falciparum and Plasmodium vivax.
Open accessAbstract
Monoclonal antibodies were raised against sporozoites of two species of malaria parasites, Plasmodium falciparum and Plasmodium vivax. The antibodies reacted with polypeptides (circumsporozoite proteins) that are uniformly distributed over the entire surface of sporozoites, as shown by indirect immunofluorescence and by the circumsporozoite precipitin reaction. The epitopes recognized by the monoclonal antibodies were expressed on sporozoites from different geographical isolates of the homologous species but were not detected on sporozoites of heterologous species nor on blood forms of the parasite. The monoclonal antibody to P. falciparum specifically immunoprecipitated two polypeptides of apparent 67,000 mol wt (Pf67) and 58,000 mol wt (Pf58) from extracts of [35S]methionine-labeled P. falciparum sporozoites. Similarly, the anti-P. vivax monoclonal immunoprecipitated two proteins of 51,000 mol wt (Pv51) and 45,000 mol wt (Pv45) from extracts of metabolically labeled P. vivax sporozoites. The extracts were also reacted with the serum of human volunteers successfully vaccinated with sporozoites of either P. vivax or P. falciparum. The patterns of immunoprecipitation were almost identical to those obtained with the corresponding monoclonal antibodies. The circumsporozoite proteins of P. falciparum and P. vivax play a role in immune protection. Incubation of the appropriate monoclonal antibody with viable sporozoites of the homologous species significantly reduced parasite infectivity, as determined by sporozoite neutralization assays carried out in splenectomized chimpanzees.
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Stoute, J. A., Slaoui, M., Heppner, D. G., Momin, P., Kester, K. E., Desmons, P., Wellde, B. T., Garçon, N., Krzych, U., Marchand, M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701093360202 · Cited by 870
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Self-citationKisalu, N. K., Idris, A. H., Weidle, C., Flores-Garcia, Y., Flynn, B. J., Sack, B. K., Murphy, S., Schön, A., Freire, E., Francica, J. R., et al. (2018) · Nature Medicine · doi:10.1038/nm.4512 · Cited by 293
Tryptophan C-mannosylation is critical for Plasmodium falciparum transmission
Lopaticki, S., McConville, R., John, A., Geoghegan, N., Mohamed, S. D., Verzier, L., Steel, R. W. J., Evelyn, C., O’Neill, M. T., Soler, N. M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32076-8 · Cited by 26
Metadata
- Authors
- Nardin, E. H., Nussenzweig, V, Nussenzweig, R. S., Collins, W. E., Harinasuta, K. T., Tapchaisri, P., & Chomcharn, Y.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1982-07-01
- Volume
- 156
- Issue
- 1
- Pages
- 20-30
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2056401826
- Cited by
- 290
- References
- 8
- FWCI
- 22.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Nardin, E. H., Nussenzweig, V, Nussenzweig, R. S., Collins, W. E., Harinasuta, K. T., Tapchaisri, P., & Chomcharn, Y. (1982). Circumsporozoite proteins of human malaria parasites Plasmodium falciparum and Plasmodium vivax. The Journal of experimental medicine. https://doi.org/10.1084/jem.156.1.20
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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