The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Malaria circumsporozoite protein binds to heparan sulfate proteoglycans associated with the surface membrane of hepatocytes.
Open accessAbstract
During feeding by infected mosquitoes, malaria sporozoites are injected into the host's bloodstream and enter hepatocytes within minutes. The remarkable target cell specificity of this parasite may be explained by the presence of receptors for the region II-plus of the circumsporozoite protein (CS) on the basolateral domain of the plasma membrane of hepatocytes. We have now identified these receptors as heparan sulfate proteoglycans (HSPG). The binding of CS to the receptors is abolished by heparitinase treatment, indicating that the recognition of region II-plus is via the glycosaminoglycan chains. We have purified and partially characterized the CS-binding HSPGs from HepG2 cells. They have a molecular weight of 400,000-700,000, are tightly associated with the plasma membrane, and are released from the cell surface by very mild trypsinization, a property which the CS receptors share with the syndecan family of proteoglycans.
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Cites
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Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans.
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Cited by
The pathogenic basis of malaria
Miller, L. H., Baruch, D. I., Marsh, K., & Doumbo, O. K. (2002) · Nature · doi:10.1038/415673a · Cited by 1,746
MSCRAMM-MEDIATED ADHERENCE OF MICROORGANISMS TO HOST TISSUES
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Microbial adherence to and invasion through proteoglycans
Rostand, K. S., & Esko, J. D. (1997) · Infection and Immunity · doi:10.1128/iai.65.1.1-8.1997 · Cited by 490
Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway.
Gluzman, I. Y., Francis, S. E., Oksman, A., Smith, C. E., Duffin, K. L., & Goldberg, D. E. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117140 · Cited by 306
Tuteja, R. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05997.x · Cited by 302
Metadata
- Authors
- Frevert, U., Sinnis, P., Cerami, C., Shreffler, W., Takacs, B., & Nussenzweig, V
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1993-05-01
- Volume
- 177
- Issue
- 5
- Pages
- 1287-1298
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2091284497
- Cited by
- 351
- References
- 40
- FWCI
- 18.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Frevert, U., Sinnis, P., Cerami, C., Shreffler, W., Takacs, B., & Nussenzweig, V. (1993). Malaria circumsporozoite protein binds to heparan sulfate proteoglycans associated with the surface membrane of hepatocytes. The Journal of experimental medicine. https://doi.org/10.1084/jem.177.5.1287
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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