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Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes.
Open accessAbstract
We have measured the release of H2O2 from granulocytes, monocytes, and macrophages during spreading on ligand-coated culture surfaces. While IgG-coated surfaces stimulate vigorous release of H2O2, neither C3b- nor C3bi-coated surfaces promoted appreciable release of H2O2 despite full ligation of C3b and C3bi receptors. We also measured release of H2O2 from cultured monocytes spreading on surfaces coated with both fibronectin and C3. Under such circumstances, the C3 receptors elicit a strong phagocytic response, but no H2O2 release was recorded. We conclude that the C3b and C3bi receptors of monocytes and granulocytes do not signal the generation of toxic oxygen intermediates from these cells.
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Citations
Cited by
Mechanisms of phagocytosis in macrophages
Aderem, A., & Underhill, D. M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.593 · Cited by 2,854
Dectin-1: a signalling non-TLR pattern-recognition receptor
Brown, G. D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1745 · Cited by 1,158
Phagocytosis of Microbes: Complexity in Action
Underhill, D. M., & Ozinsky, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.103001.114744 · Cited by 1,124
An integrated model of the recognition of Candida albicans by the innate immune system
Netea, M. G., Brown, G. D., Kullberg, B. J., & Gow, N. A. R. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1815 · Cited by 946
Malik, Z. A., Denning, G. M., & Kusner, D. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.2.287 · Cited by 331
Metadata
- Authors
- Wright, S. D., & Silverstein, S. C.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1983-12-01
- Volume
- 158
- Issue
- 6
- Pages
- 2016-2023
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2155099281
- Cited by
- 487
- References
- 0
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wright, S. D., & Silverstein, S. C. (1983). Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes. The Journal of experimental medicine. https://doi.org/10.1084/jem.158.6.2016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
