The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Modulation of endothelial cell hemostatic properties by tumor necrosis factor.
Open accessAbstract
Tumor necrosis factor/cachectin (TNF) is a mediator of the septic state, which involves diffuse abnormalities of coagulation throughout the vasculature. Since previous studies have shown that endothelial cells can play an active role in coagulation, we wished to determine whether TNF could modulate endothelial cell hemostatic properties. Incubation of purified recombinant TNF with cultured endothelial cells resulted in a time- and dose-dependent acquisition of tissue factor procoagulant activity. Concomitant with enhanced procoagulant activity, TNF also suppressed endothelial cell cofactor activity for the anticoagulant protein C pathway; both thrombin-mediated protein C activation and formation of functional activated protein C-protein S complex on the cell surface were considerably attenuated. Comparable concentrations of TNF (half-maximal affect at approximately 50 pM) and incubation times (half-maximal affect by 4 h after addition to cultures) were required for each of these changes in endothelial cell coagulant properties. This unidirectional shift in cell surface hemostatic properties favoring promotion of clot formation indicates that, in addition to leukocyte procoagulants, endothelium can potentially be instrumental in the pathogenesis of the thrombotic state associated with inflammatory and malignant disorders.
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Citations
Cites
Beutler, B., Milsark, I. W., & Cerami, A. C. (1985) · Science · doi:10.1126/science.3895437 · Cited by 2,352
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
Pennica, D., Nedwin, G. E., Hayflick, J. S., Seeburg, P. H., Derynck, R., Palladino, M. A., Kohr, W. J., Aggarwal, B. B., & Goeddel, D. V. (1984) · Nature · doi:10.1038/312724a0 · Cited by 1,736
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
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Bevilacqua, M. P., Pober, J. S., Majeau, G. R., Cotran, R. S., & Gimbrone, M. A. (1984) · The Journal of experimental medicine · doi:10.1084/jem.160.2.618 · Cited by 935
Natural anticoagulant mechanisms.
Rosenberg, R. D., & Rosenberg, J. S. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111389 · Cited by 258
Self-regulation of procoagulant events on the endothelial cell surface.
Stern, D. M., Bank, I., Nawroth, P. P., Cassimeris, J., Kisiel, W., Fenton, J. W., Dinarello, C., Chess, L., & Jaffe, E. A. (1985) · The Journal of experimental medicine · doi:10.1084/jem.162.4.1223 · Cited by 223
Self-citationA factor X-activating cysteine protease from malignant tissue.
Gordon, S. G., & Cross, B. A. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110203 · Cited by 219
An endothelial cell-dependent pathway of coagulation.
Stern, D., Nawroth, P. P., Handley, D. A., & Kisiel, W. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.8.2523 · Cited by 205
Self-citationPurification and characterization of bovine tissue factor.
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Cited by
Secretory products of macrophages.
Nathan, C. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112815 · Cited by 2,615
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Cachectin and tumour necrosis factor as two sides of the same biological coin
Beutler, B., & Cerami, A. (1986) · Nature · doi:10.1038/320584a0 · Cited by 1,647
Vascular Endothelial Cell Biology: An Update
Krüger-Genge, A., Blocki, A., Franke, R.-P., & Jung, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184411 · Cited by 1,163
Intercellular adhesion molecule-1
van de Stolpe, A., & van der Saag, P. T. (1996) · Journal of Molecular Medicine · doi:10.1007/bf00202069 · Cited by 802
Metadata
- Authors
- Nawroth, P. P., & Stern, D. M.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1986-03-01
- Volume
- 163
- Issue
- 3
- Pages
- 740-745
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2105054347
- Cited by
- 1,311
- References
- 9
- FWCI
- 54.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
