Intercellular adhesion molecule-1

van de Stolpe, A.; van der Saag, P. T.

doi:10.1007/bf00202069

Cited by 802Cell Adhesion Molecules ResearchNF-κB Signaling PathwaysChemokine receptors and signaling

Intercellular adhesion molecule-1

van de Stolpe, A., van der Saag, P. T.·1996·Journal of Molecular Medicine

DOI 10.1007/bf00202069

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Abstract

The intercellular adhesion molecule (ICAM) 1 is an Ig-like cell adhesion molecule expressed by several cell types, including leukocytes and endothelial cells. It can be induced in a cell-specific manner by several cytokines, for example, tumor necrosis factor-alpha, interleukin-1, and interferon-gamma, and inhibited by glucocorticoids. Its ligands are the membrane-bound integrin receptors LFA-1 and Mac-1 on leukocytes, CD43, the soluble molecule fibrinogen, the matrix factor hyaluronan, rhinoviruses, and Plasmodium falciparum malaria-infected erythrocytes. ICAM-1 expression is predominantly transcriptionally regulated. The ICAM-1 promoter contains several enhancer elements, among them a novel kappa B element which mediates effects of 12-O-tetradecanoylphorbol-13-acetate, interleukin-1, lipopolysaccharide, tumor necrosis factor-alpha, and glucocorticoids. Expression regulation is cell specific and depends on the availability of cytokine/hormone receptors, signal transduction pathways, transcription factors, and posttranscriptional modification. ICAM-1 plays a role in inflammatory processes and in the T-cell mediated host defense system. It functions as a costimulatory molecule on antigen-presenting cells to activate MHC class II restricted T-cells, and on other cell types in association with MHC class I to activate cytotoxic T-cells. ICAM-1 on endothelium plays an important role in migration of (activated) leukocytes to sites of inflammation. ICAM-1 is shed by the cell and detected in plasma as sICAM-1. Regulation and significance of sICAM-1 are as yet unclear, but sICAM-1 is increased in many pathological conditions. ICAM-1 may play a pathogenetic role in rhinovirus infections. Derangement of ICAM-1 expression probably contributes to the clinical manifestations of a variety of diseases, predominantly by interfering with normal immune function. Among these are malignancies (e.g., melanoma and lymphomas), many inflammatory disorders (e.g., asthma and autoimmune disorders), atherosclerosis, ischemia, certain neurological disorders, and allogeneic organ transplantation. Interference with ICAM-1 leukocyte interaction using mAbs, soluble ICAM-1, antisense ICAM-1 RNA, and in the case of melanoma mAb-coupled immunotoxin, may offer therapeutic possibilities in the future. Integration of knowledge concerning membrane-bound and soluble ICAM-1 into a single functional system is likely to contribute to elucidating the immunoregulatory function of ICAM-1 and its pathophysiological significance in various disease entities.

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The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477 · see citing works
Cadherin Cell Adhesion Receptors as a Morphogenetic Regulator
Takeichi, M. (1991) · Science · doi:10.1126/science.2006419 · Cited by 3,283 · see citing works
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
Angel, P. E., Imagawa, M., Chiu, R., Stein, B., Imbra, R. J., Rahmsdorf, H. J., Jonat, C., Herrlich, P. A., & Karin, M. (1987) · Cell · doi:10.1016/0092-8674(87)90611-8 · Cited by 2,930 · see citing works
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
Butcher, E. C. (1991) · Cell · doi:10.1016/0092-8674(91)90279-8 · Cited by 2,789 · see citing works
Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
Dustin, M. L., Rothlein, R., Bhan, A. K., Dinarello, C. A., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.1.245 · Cited by 2,450 · see citing works
Integrins and other cell adhesion molecules
Albelda, S. Μ., & Buck, C. A. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.11.2199285 · Cited by 1,975 · see citing works
Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
Osborn, L., Hession, C. A., Tizard, R., Vassallo, C., Luhowskyj, S., Rosso, G. C., & Lobb, R. R. (1989) · Cell · doi:10.1016/0092-8674(89)90775-7 · Cited by 1,690 · see citing works
Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)
Marlin, S. D., & Springer, T. A. (1987) · Cell · doi:10.1016/0092-8674(87)90104-8 · Cited by 1,686 · see citing works
T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
Dustin, M. L., & Springer, T. A. (1989) · Nature · doi:10.1038/341619a0 · Cited by 1,547 · see citing works
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.
Pober, J. S., Gimbrone, M. A., Lapierre, L. A., Mendrick, D. L., Fiers, W., Rothlein, R., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.6.1893 · Cited by 1,413 · see citing works
A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.
Rothlein, R., Dustin, M. L., Marlin, S. D., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.4.1270 · Cited by 1,400 · see citing works
Modulation of endothelial cell hemostatic properties by tumor necrosis factor.
Nawroth, P. P., & Stern, D. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.163.3.740 · Cited by 1,325 · see citing works
PECAM-1 is required for transendothelial migration of leukocytes.
Müller, W. A., Weigl, S. A., Deng, X., & Phillips, D. M. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.2.449 · Cited by 1,151 · see citing works
The major human rhinovirus receptor is ICAM-1
Greve, J. M., Davis, G. L., Meyer, A., Forte, C. P., Yost, S. C., Marlor, C. W., Kamarck, M. E., & McClelland, A. (1989) · Cell · doi:10.1016/0092-8674(89)90688-0 · Cited by 1,149 · see citing works
Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.
Ray, A., & Prefontaine, K. E. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.752 · Cited by 1,064 · see citing works
Mechanism of transcriptional activation by Sp1: Evidence for coactivators
Pugh, B. F., & Tjian, R. (1990) · Cell · doi:10.1016/0092-8674(90)90683-6 · Cited by 1,031 · see citing works
PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.
Newman, P., Berndt, M., Gorski, J., White, G. C., Lyman, S., Paddock, C., & Muller, W. (1990) · Science · doi:10.1126/science.1690453 · Cited by 1,011 · see citing works
Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.
Dustin, M. L., & Springer, T. A. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.1.321 · Cited by 985 · see citing works
Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families
Staunton, D. E., Marlin, S. D., Stratowa, C., Dustin, M. L., & Springer, T. A. (1988) · Cell · doi:10.1016/0092-8674(88)90434-5 · Cited by 954 · see citing works
Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of asthma
Wegner, C. D., Gundel, R. H., Reilly, P. L., Haynes, N., Letts, L. G., & Rothlein, R. (1990) · Science · doi:10.1126/science.1967851 · Cited by 898 · see citing works
ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).
Diamond, M., Staunton, D. E., de Fougerolles, A. R., Stacker, S. A., García‐Aguilar, J., Hibbs, M. L., & Springer, T. A. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.6.3129 · Cited by 881 · see citing works
Experimental endotoxemia in humans: analysis of cytokine release and coagulation, fibrinolytic, and complement pathways
van Deventer, S. J. H., Buller, H. R., ten Cate, J. W., Aarden, L. A., Hack, C. E., & Sturk, A. (1990) · Blood · doi:10.1182/blood.v76.12.2520.bloodjournal76122520 · Cited by 850 · see citing works
Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1
Staunton, D. E., Dustin, M. L., & Springer, T. A. (1989) · Nature · doi:10.1038/339061a0 · Cited by 829 · see citing works
A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses
Staunton, D. E., Merluzzi, V. J., Rothlein, R., Barton, R., Marlin, S. D., & Springer, T. A. (1989) · Cell · doi:10.1016/0092-8674(89)90689-2 · Cited by 821 · see citing works
Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors
Scheinman, R. I., Gualberto, A., Jewell, C. M., Cidlowski, J. A., & Baldwin, A. S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.943 · Cited by 819 · see citing works
The LFA-1 ligand ICAM-1 provides an important costimulatory signal for T cell receptor-mediated activation of resting T cells.
van Seventer, G. A., Shimizu, Y., Horgan, K. J., et al. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.12.4579 · Cited by 790 · see citing works
The expression of the adhesion molecules ICAM‐1, VCAM‐1, PECAM, and E‐selectin in human atherosclerosis
Davies, M. J., Gordon, J. L., Gearing, A. J. H., Pigott, R., Woolf, N., Katz, D. R., & Kyriakopoulos, A. (1993) · The Journal of Pathology · doi:10.1002/path.1711710311 · Cited by 777 · see citing works
Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation
Diamond, M., Staunton, D. E., Marlin, S. D., & Springer, T. A. (1991) · Cell · doi:10.1016/0092-8674(91)90548-d · Cited by 773 · see citing works
A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.
Cronstein, B. N., Kimmel, S. C., Levin, R. I., Martiniuk, F. T., & Weissmann, G. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.9991 · Cited by 725 · see citing works
Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1
Isobe, M., Yagita∥, H., Okumura, K., & Ihara, A. (1992) · Science · doi:10.1126/science.1347662 · Cited by 716 · see citing works
The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus
Staunton, D. E., Dustin, M. L., Erickson, H., & Springer, T. A. (1990) · Cell · doi:10.1016/0092-8674(90)90805-o · Cited by 697 · see citing works
A form of circulating ICAM-1 in human serum
Rothlein, R., Mainolfi, E. A., Czajkowski, M., et al. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3788 · Cited by 690 · see citing works
Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum
Berendt, A. R., Simmons, D. L., Tansey, J., Newbold, C., & Marsh, K. (1989) · Nature · doi:10.1038/341057a0 · Cited by 689 · see citing works
Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells
Pigott, R., Dillon, L. P., Hemingway, I., & Gearing, A. J. H. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91234-h · Cited by 650 · see citing works
Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element.
Resnick, N. M., Collins, T., Atkinson, W., Bonthron, D. T., Dewey, C. F., & Gimbrone, M. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4591 · Cited by 631 · see citing works
Cross‐coupling of the NF‐kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.
Stein, B., Baldwin, A. S., Ballard, D. W., Greene, W. C., Angel, P. E., & Herrlich, P. A. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06066.x · Cited by 630 · see citing works
ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM
Simmons, D., Makgoba, M. W., & Seed, B. (1988) · Nature · doi:10.1038/331624a0 · Cited by 630 · see citing works
Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration.
Smith, C. W., Rothlein, R., Hughes, B. J., Mariscalco, M. M., Rudloff, H. E., Schmalstieg, F. C., & Anderson, D. C. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113788 · Cited by 599 · see citing works
Expression of intercellular adhesion molecule-1 in atherosclerotic plaques.
Poston, R. N., Haskard, D. O., Coucher, J., Gall, N. P., & Johnson-Tidey, R. R. (1992) · PubMed Central · Cited by 583 · see citing works
Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells.
Nagel, T., Resnick, N., Atkinson, W. J., Dewey, C. F., & Gimbrone, M. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117410 · Cited by 581 · see citing works
ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells
Makgoba, M. W., Sanders, M. E., Luce, G. E. G., Dustin, M. L., Springer, T. A., Clark, E. A., Mannoni, P., & Shaw, S. (1988) · Nature · doi:10.1038/331086a0 · Cited by 573 · see citing works
Induction of intercellular adhesion molecule 1 on primary and continuous cell lines by pro-inflammatory cytokines. Regulation by pharmacologic agents and neutralizing antibodies.
Rothlein, R., Czajkowski, M., O'Neill, M., Marlin, S. D., Mainolfi, E. A., & Merluzzi, V. J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.5.1665 · Cited by 563 · see citing works
Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1.
Sligh, J. E., Ballantyne, C. M., Rich, S. S., Hawkins, H. K., Smith, C. W., Bradley, A., & Beaudet, A. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8529 · Cited by 562 · see citing works
Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells
Ledebur, H. C., & Parks, T. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.2.933 · Cited by 536 · see citing works
Functional and Physical Associations between NF-κB and C/EBP Family Members: a Rel Domain-bZIP Interaction
Stein, B., Cogswell, P. C., & Baldwin, A. S. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.3964 · Cited by 516 · see citing works
A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.
Diamond, M., & Springer, T. A. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.2.545 · Cited by 515 · see citing works
E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro.
Leeuwenberg, J. F. M., Smeets, E. F., Neefjes, J., Shaffer, M., Cinek, T., Jeunhomme, T. M. A. A., Ahern, T. J., & Buurman, W. A. (1992) · PubMed Central · Cited by 510 · see citing works
Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.
de Fougerolles, A. R., Stacker, S. A., Schwarting, R., & Springer, T. A. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.1.253 · Cited by 495 · see citing works
Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids.
Caldenhoven, E., Lidén, J., Wissink, S., van de Stolpe, A., Raaijmakers, J. A. M., Koenderman, L., Okret, S., Gustafsson, J., & van der Saag, P. T. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.4.7659084 · Cited by 490 · see citing works
Acute promyelocytic leukemia: from genetics to treatment
Grignani, F., Fagioli, M., Alcalay, M., Longo, L., Pandolfi, P. P., Donti, E., Biondi, A., Coco, F. L., Grignani, F., & Pelicci, P. G. (1994) · Blood · doi:10.1182/blood.v83.1.10.bloodjournal83110 · Cited by 490 · see citing works
Selection of Optimal κB/Rel DNA-Binding Motifs: Interaction of Both Subunits of NF-κB with DNA Is Required for Transcriptional Activation
KUNSCH, C. A., Ruben, S. M., & Rosen, C. A. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4412-4421.1992 · Cited by 488 · see citing works
A cooperative interaction between NF‐kappa B and Sp1 is required for HIV‐1 enhancer activation.
Perkins, N. D., Edwards, N. L., Duckett, C. S., Agranoff, A. B., Schmid, R. M., & Nabel, G. J. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06029.x · Cited by 484 · see citing works
Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice.
Xu, H., Gonzalo, J. A., St‐Pierre, Y., Williams, I. R., Kupper, T. S., Cotran, R. S., Springer, T. A., & Gutierrez‐Ramos, J. C. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.95 · Cited by 483 · see citing works
Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes
van Kooyk, Y., Kemenade, P. V. D. W.-V., Weder, P., Kuijpers, T. W., & Figdor, C. G. (1989) · Nature · doi:10.1038/342811a0 · Cited by 468 · see citing works
Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms.
Chiang, M. Y.-N., Chan, H., Zounes, M. A., Freier, S., Lima, W. F., & Bennett, C. F. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55250-9 · Cited by 463 · see citing works
Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes.
de Fougerolles, A. R., & Springer, T. A. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.1.185 · Cited by 432 · see citing works
The inducible transcription factor NF-κB: structure-function relationship of its protein subunits
Grimm, S., & Baeuerle, P. A. (1993) · Biochemical Journal · doi:10.1042/bj2900297 · Cited by 430 · see citing works
Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions.
Lemanske, R. F., Dick, E. C., Swenson, C. A., Vrtis, R. F., & Busse, W. W. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113843 · Cited by 413 · see citing works
Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5’-regulatory region. Induction by cytokines and phorbol ester
Voraberger, G., Schäfer, R., & Stratowa, C. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.8.2777 · Cited by 410 · see citing works
Soluble Forms of Vascular Adhesion Molecules, E‐Selectin, ICAM‐1, and VCAM‐1: Pathological Significance
Gearing, A. J. H., Hemingway, I., PIGOIT, R., Hughes, J., Rees, A. J., & Cashman, S. J. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb51633.x · Cited by 399 · see citing works
Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system.
Sobel, R. A., Mitchell, M. E., & Fondren, G. (1990) · PubMed · Cited by 390 · see citing works
B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50
Neri, A., Chang, C.-C., Lombardi, L. T., Salina, M., Corradini, P., Maiolo, A. T., Chaganti, R. S. K., & Dalla‐Favera, R. (1991) · Cell · doi:10.1016/0092-8674(91)90285-7 · Cited by 390 · see citing works
Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes
Damle, N. K., Klussman, K., Linsley, P. S., & Aruffo, A. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.1985 · Cited by 386 · see citing works
Differential utilization of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T lymphocytes
Oppenheimer‐Marks, N., Davis, L. S., Bogue, D. T., Ramberg, J. E., & Lipsky, P. E. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.9.2913 · Cited by 383 · see citing works
Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells
Altmann, D. M., Hogg, N., Trowsdale, J., et al. (1989) · Nature · doi:10.1038/338512a0 · Cited by 383 · see citing works
Circulating ICAM-1 isoforms: diagnostic prospects for inflammatory and immune disorders
Seth, R. (1991) · The Lancet · doi:10.1016/0140-6736(91)90077-3 · Cited by 378 · see citing works
Interleukin‐10 inhibits B7 and intercellular adhesion molecule‐1 expression on human monocytes
Willems, F., Marchant, A., Delville, J., Gerard, C. M., Delvaux, A., Velu, T. J., Boer, M. D., & Goldman, M. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240435 · Cited by 376 · see citing works
De novo expression of intercellular-adhesion molecule 1 in melanoma correlates with increased risk of metastasis.
Johnson, J. P., Stade, B. G., Holzmann, B., et al. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.2.641 · Cited by 363 · see citing works
The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression
Read, M. A., Neish, A. S., Luscinskas, F. W., Palombella, V. J., Maniatis, T., & Collins, T. (1995) · Immunity · doi:10.1016/1074-7613(95)90030-6 · Cited by 347 · see citing works
The function of human intercellular adhesion molecule‐1 (ICAM‐1) in the generation of an immune response
Dougherty, G. J., Murdoch, S., & Hogg, N. (1988) · European Journal of Immunology · doi:10.1002/eji.1830180107 · Cited by 346 · see citing works
Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes
Fawcett, J., Holness, C. L. L., Needham, L. A., et al. (1992) · Nature · doi:10.1038/360481a0 · Cited by 344 · see citing works
Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway
Languino, L. R., Plescia, J., Alain Duperray, B., Brian, A. A., Plow, E. F., Geltosky, J. E., & Altieri, D. C. (1993) · Cell · doi:10.1016/0092-8674(93)90367-y · Cited by 343 · see citing works
Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage.
Kurose, I., Kubes, P., Wolf, R., Anderson, D. C., Paulson, J. C., Miyasaka, M., & Granger, D. N. (1993) · Circulation Research · doi:10.1161/01.res.73.1.164 · Cited by 342 · see citing works
Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions.
van der Wal, A. C., Das, P. K., Tigges, A. J., & Becker, A. E. (1992) · PubMed Central · Cited by 336 · see citing works
Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface.
Shreeniwas, R., Koga, S., Karakurum, M., Pinsky, D. J., Kaiser, E., Brett, J., Wolitzky, B. A., Norton, C. R., Plocinski, J. M., & Benjamin, W. R. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116122 · Cited by 335 · see citing works
Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance.
Gregory, C. D., Murray, R. J., Edwards, C., et al. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.6.1811 · Cited by 335 · see citing works
Intracellular oxidative stress induced by nitric oxide synthesis inhibition increases endothelial cell adhesion to neutrophils.
Niu, X. F., Smith, C. W., & Kubes, P. (1994) · Circulation Research · doi:10.1161/01.res.74.6.1133 · Cited by 333 · see citing works
Association of intercellular adhesion molecule-1 (ICAM-1) with actin-containing cytoskeleton and alpha-actinin.
Carpén, O., Pallai, P. V., Staunton, D. E., & Springer, T. A. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.5.1223 · Cited by 309 · see citing works
Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells.
Koopman, G., Keehnen, R. M. J., Lindhout, E., Newman, W., Shimizu, Y., van Seventer, G. A., de Groot, C., & Pals, S. T. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.8.3760 · Cited by 303 · see citing works
A PHASE I TRIAL OF IMMUNOSUPPRESSION WITH ANTIIC AM-1 (CD54) mAb IN RENAL ALLOGRAFT RECIPIENTS
Haug, C. E., Colvin, R. B., Delmonico, F. L., et al. (1993) · Transplantation · doi:10.1097/00007890-199304000-00016 · Cited by 300 · see citing works
Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies
Banks, R. E., Gearing, A., Hemingway, I., et al. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.298 · Cited by 293 · see citing works
Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters.
Dean, N. M., McKay, R. A., Condon, T. P., & Bennett, C. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34023-1 · Cited by 291 · see citing works
Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion.
Sugama, Y., Tiruppathì, C., offakidevi, K., Andersen, T. T., Fenton, J. W., & Malik, A. B. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.4.935 · Cited by 286 · see citing works
A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infection
Marlin, S. D., Staunton, D. E., Springer, T. A., et al. (1990) · Nature · doi:10.1038/344070a0 · Cited by 283 · see citing works
Induction of ICAM-1 Expression on Human Airway Epithelial Cells by Inflammatory Cytokines: Effects on Neutrophil-Epithelial Cell Adhesion
Tosi, M. F., Stark, J. M., Smith, C. W., et al. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/7.2.214 · Cited by 279 · see citing works
Shedding of ICAM-1 from human melanoma cell lines induced by IFN-gamma and tumor necrosis factor-alpha. Functional consequences on cell-mediated cytotoxicity
Becker, J. C., Dummer, R., Hartmann, A., et al. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.12.4398 · Cited by 272 · see citing works
Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies.
Bini, A., Fenoglio, J. J., Mesa‐Tejada, R., Kudryk, B. J., & Kaplan, K. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.1.109 · Cited by 267 · see citing works
12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter.
van de Stolpe, A., Caldenhoven, E., Stade, B. G., Koenderman, L., Raaijmakers, J. A. M., Johnson, J. P., & van der Saag, P. T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37586-5 · Cited by 264 · see citing works
CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1
Rosenstein, Y., Park, J. K., Hahn, W. C., et al. (1991) · Nature · doi:10.1038/354233a0 · Cited by 261 · see citing works
Intercellular adhesion molecule-1 gene expression in human endothelial cells. Differential regulation by tumor necrosis factor-alpha and phorbol myristate acetate.
Wertheimer, S. J., Myers, C. L., Wallace, R. W., & Parks, T. P. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49801-3 · Cited by 257 · see citing works
Regulation of Adhesion to ICAM-1 by the Cytoplasmic Domain of LFA-1 Integrin β Subunit
Hibbs, M. L., Xu, H., Stacker, S. A., et al. (1991) · Science · doi:10.1126/science.1672776 · Cited by 257 · see citing works
Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides.
Bennett, C. F., Condon, T. P., Grimm, S., Chan, H., & Chiang, M. Y. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.7.3530 · Cited by 252 · see citing works
cDNA cloning reveals that the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1.
Tomassini, J. E., Graham, D., DeWitt, C. M., Lineberger, D. W., Rodkey, J. A., & Colonno, R. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.4907 · Cited by 248 · see citing works
Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells.
Durieu-Trautmann, O., Chaverot, N., Cazaubon, S. M., Strosberg, A. D., & Couraud, P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99908-4 · Cited by 237 · see citing works
Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1.
Cid, M. C., Kleinman, H. K., Grant, D. S., Schnaper, H. W., Fauci, A. S., & Hoffman, G. S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116941 · Cited by 231 · see citing works
Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1.
Hou, J., Baichwal, V. R., & Cao, Z. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11641 · Cited by 217 · see citing works
Molecular Basis of Sequestration in Severe and Uncomplicated Plasmodium falciparum Malaria: Differential Adhesion of Infected Erythrocytes to CD36 and ICAM-l
Ockenhouse, C., Ho, M., Tandon, N., van Seventer, G. A., Shaw, S., White, N. J., Jamieson, G., Chulay, J. D., & Webster, H. K. (1991) · The Journal of Infectious Diseases · doi:10.1093/infdis/164.1.163 · Cited by 215 · see citing works
Antibodies against intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 prevent glomerular injury in rat experimental crescentic glomerulonephritis
Kawasaki, K., Yaoita, E., Yamamoto, T. S., et al. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.3.1074 · Cited by 211 · see citing works
Cloning and characterization of a new intercellular adhesion molecule ICAM-R
Vazeux, R., Hoffman, P. A., Tomfta, J. K., Dkkinson, E. S., Jasman, R. L., John, T. S., & Gallatin, W. M. (1992) · Nature · doi:10.1038/360485a0 · Cited by 202 · see citing works
Kinetics and characterization of intercellular adhesion molecule-1 (ICAM-1) expression on keratinocytes in various inflammatory skin lesions and malignant cutaneous lymphomas
Vejlsgaard, G. L., Ralfkiaer, E. M., Avnstorp, C., et al. (1989) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(89)70090-6 · Cited by 197 · see citing works
Intercellular adhesion molecule-1 is a cell surface receptor for hyaluronan.
McCourt, P., Ek, B., Forsberg, N., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43775-1 · Cited by 195 · see citing works
Intercellular adhesion molecule-1 (ICAM-1) expression is upregulated in autoimmune murine lupus nephritis.
Wuthrich, R. P., Jevnikar, A. M., Takei, F., Glimcher, L. H., & Kelley, V. E. (1990) · PubMed Central · Cited by 194 · see citing works
The role of PECAM-1 (CD31) in leukocyte emigration: studies in vitro and in vivo
Müller, W. A. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.57.4.523 · Cited by 192 · see citing works
Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1
Arnould, T., Michiels, C., & Remacle, J. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.5.c1102 · Cited by 190 · see citing works
Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1
Pober, J. S., Slowik, M. R., Luca, L., et al. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.11.5114 · Cited by 189 · see citing works
Production of tumor necrosis factor and interleukin-1 by macrophages from human atheromatous plaques.
Tipping, P. G., & Hancock, W. W. (1993) · PubMed · Cited by 186 · see citing works
Regulation of leukocyte-endothelium interaction and leukocyte transendothelial migration by intercellular adhesion molecule 1-fibrinogen recognition.
Languino, L. R., Alain Duperray, B., Joganic, K. J., Fornaro, M., Thornton, G. B., & Altieri, D. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1505 · Cited by 186 · see citing works
The Signalling Pathways of Interleukin-6 and Gamma Interferon Converge by the Activation of Different Transcription Factors Which Bind to Common Responsive DNA Elements
Yuan, J., Wegenka, U. M., Lütticken, C., Buschmann, J., Decker, T., Schindler, C., Heinrich, P. C., & Horn, F. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1657 · Cited by 179 · see citing works
Reactive oxygen species rapidly increase endothelial ICAM-1 ability to bind neutrophils without detectable upregulation
Sellak, H., Franzini, E., Hakim, J., & Pasquier, C. (1994) · Blood · doi:10.1182/blood.v83.9.2669.2669 · Cited by 172 · see citing works
Cloning and characterization of the 5'-transcriptional regulatory region of the human intercellular adhesion molecule 1 gene
Degitz, K., Li, L.-J., & Caughman, S. W. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92805-x · Cited by 172 · see citing works
Epidermal Keratiocytes Express the Adhesion Molecule Intercellular Adhesion Molecule-1 in Inflammatory Dermatoses.
Singer, K. H., Tuck, D. T., Sampson, H. A., et al. (1989) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12722441 · Cited by 172 · see citing works
Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses.
de Fougerolles, A. R., Qin, X., & Springer, T. A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.619 · Cited by 170 · see citing works
Identification and distribution of fibrinogen, fibrin and fibrin (ogen) degradation products in atherosclerosis
Bini, A. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · Cited by 169 · see citing works
Plasmodium falciparum-infected erythrocytes bind ICAM-1 at a site distinct from LFA-1, Mac-1, and human rhinovirus
Ockenhouse, C. F., Betageri, R., Springer, T. A., & Staunton, D. E. (1992) · Cell · doi:10.1016/0092-8674(92)90206-r · Cited by 168 · see citing works
Tumor necrosis factor mediates experimental pulmonary edema by ICAM-1 and CD18-dependent mechanisms.
Lo, S. K., Everitt, J. I., Gu, J., & Malik, A. B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115681 · Cited by 167 · see citing works
Expression of immunologically relevant endothelial cell activation antigens on isolated central neurvous system microvessels from patients with multiple sclerosis
Washington, R. A., Burton, J., Todd, R. F., Newman, W., Dragovic, L. J., & Dore‐Duffy, P. (1994) · Annals of Neurology · doi:10.1002/ana.410350114 · Cited by 167 · see citing works
Hydrogen peroxide-induced increase in endothelial adhesiveness is dependent on ICAM-1 activation
Lo, S. K., Janakidevi, K., Lai, L., et al. (1993) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1993.264.4.l406 · Cited by 166 · see citing works
ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway.
Campanero, M. R., del Pozo, M. Á., Arroyo, A. G., et al. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.4.1007 · Cited by 165 · see citing works
Regulation of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 in human vascular smooth muscle cells.
Couffinhal, T., Duplàa, C., Moreau, C., et al. (1994) · Circulation Research · doi:10.1161/01.res.74.2.225 · Cited by 162 · see citing works
Induction of ICAM-1 by TNF-alpha, IL-1 beta, and LPS in human endothelial cells after downregulation of PKC
Myers, C. L., Wertheimer, S. J., Schembri-King, J., et al. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.263.4.c767 · Cited by 161 · see citing works
Integrin regulation of leukocyte inflammatory functions. CD11b/CD18 enhancement of the tumor necrosis factor-alpha responses of monocytes
Fan, S. T., & Edgington, T. S. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.7.2972 · Cited by 161 · see citing works
Interactions of leukocyte integrins with intercellular adhesion molecule 1 in the production of inflammatory vascular injury in vivo. The Shwartzman reaction revisited.
Argenbright, L. W., & Barton, R. W. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115570 · Cited by 157 · see citing works
A set of inducible genes expressed by activated human monocytic and endothelial cells contain kappa B-like sites that specifically bind c-Rel-p65 heterodimers.
Parry, G. C., & Mackman, N. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31895-1 · Cited by 151 · see citing works
Extracellular Ca2+ modulates leukocyte function-associated antigen-1 cell surface distribution on T lymphocytes and consequently affects cell adhesion
van Kooyk, Y., Weder, P., Heije, K., et al. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.6.1061 · Cited by 147 · see citing works
Endothelin induction of adhesion molecule expression on human brain microvascular endothelial cells
McCarron, R. M., Wang, L., Stanimirovic, D. B., & Spatz, M. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90432-k · Cited by 145 · see citing works
Expression and Modulation of Adhesion Molecules on Human Bronchial Epithelial Cells
Bloemen, P. G. M., van den Tweel, M. C., Henricks, P. A. J., Engels, F., Wagenaar, S. S., Rutten, A. A. J. J. L., & Nijkamp, F. P. (1993) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/9.6.586 · Cited by 145 · see citing works
Mechanisms of receptor-mediated rhinovirus neutralization defined by two soluble forms of ICAM-1
Greve, J. M., Forte, C. P., Marlor, C. W., et al. (1991) · Journal of Virology · doi:10.1128/jvi.65.11.6015-6023.1991 · Cited by 141 · see citing works
Expression on blood cells of sialophorin, the surface glycoprotein that is defective in Wiskott-Aldrich syndrome
Remold‐O’Donnell, E., Zimmerman, C., Kenney, D., & Rosen, F. S. (1987) · Blood · doi:10.1182/blood.v70.1.104.104 · Cited by 140 · see citing works
Soluble intercellular adhesion molecule-1 inhibits MHC-restricted specific T cell/tumor interaction.
Becker, J. C., Termeer, C., Schmidt, R. E., et al. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.12.7224 · Cited by 140 · see citing works
Expression of the adhesion molecule ICAM-1 and major histocompatibility complex class I antigens on human tumor cells is required for their interaction with autologous lymphocytes in vitro
Vánky, F. B., Wang, P., Patarroyo, M. E., et al. (1990) · Cancer Immunology Immunotherapy · doi:10.1007/bf01742491 · Cited by 138 · see citing works
Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders
Akiyama, H., Kawamata, T., Yamada, T., Tooyama, I., Ishii, T., & McGeer, P. L. (1993) · Acta Neuropathologica · doi:10.1007/bf00334673 · Cited by 137 · see citing works
Cytokine-induced beta-galactoside alpha-2,6-sialyltransferase in human endothelial cells mediates alpha 2,6-sialylation of adhesion molecules and CD22 ligands.
Hanasaki, K., Varki, A. P., Stamenkovic, I., & Bevilacqua, M. P. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34107-8 · Cited by 134 · see citing works
Nickel Chloride and Cobalt Chloride, Two Common Contact Sensitizers, Directly Induce Expression of Intercellular Adhesion Molecule-1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1), and Endothelial Leukocyte Adhesion Molecule (ELAM-1) by Endothelial Cells
Goebeler, M., Meinardus‐Hager, G., Roth, J., et al. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12476328 · Cited by 132 · see citing works
Participation of the transcription factor C/EBP delta in the acute-phase regulation of the human gene for complement component C3.
Juan, T., Wilson, D. R., Wilde, M., & Darlington, G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.7.2584 · Cited by 132 · see citing works
The distribution of adhesion molecules in human atherosclerosis
Wood, K. M., Cadogan, M. D., Ramshaw, A. L., et al. (1993) · Histopathology · doi:10.1111/j.1365-2559.1993.tb00157.x · Cited by 128 · see citing works
Lysophosphatidylcholine in oxidized low-density lipoprotein increases endothelial susceptibility to polymorphonuclear leukocyte-induced endothelial dysfunction in porcine coronary arteries. Role of protein kinase C.
Sugiyama, S., Kugiyama, K., Ohgushi, M., et al. (1994) · Circulation Research · doi:10.1161/01.res.74.4.565 · Cited by 123 · see citing works
Intercellular adhesion molecule-1 mediates the expression of monocyte- derived MIP-1 alpha during monocyte-endothelial cell interactions
Lukacs, N. W., Strieter, R. M., Elner, V. M., et al. (1994) · Blood · doi:10.1182/blood.v83.5.1174.1174 · Cited by 120 · see citing works
Expression of intercellular adhesion molecule-1 in murine hearts with acute myocarditis caused by coxsackievirus B3.
Seko, Y., Matsuda, H., Kato, K., Hashimoto, Y., Yagita∥, H., Okumura, K., & Yazaki, Y. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116333 · Cited by 120 · see citing works
Functional and Physical Associations between NF-κB and C/EBP Family Members: a Rel Domain-bZIP Interaction
Stein, B., Cogswell, P. C., & Baldwin, A. S. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.3964-3974.1993 · Cited by 120 · see citing works
Differing regulation and function of ICAM-1 and class II antigens on renal tubular cells
Jevnikar, A. M., Wuthrich, R. P., Takei, F., Xu, H.-W., Brennan, D. C., Glimcher, L. H., & Rubin‐Kelley, V. E. (1990) · Kidney International · doi:10.1038/ki.1990.221 · Cited by 119 · see citing works
Isolation of the murine intercellular adhesion molecule 1 (ICAM-1) gene. ICAM-1 enhances antigen-specific T cell activation.
Siu, G., Hedrick, S. Μ., & Brian, A. A. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.11.3813 · Cited by 118 · see citing works
Selective interaction of a subset of interferon-gamma response element-binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells.
Look, D. C., Pelletier, M. R., & Holtzman, M. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37060-6 · Cited by 118 · see citing works
Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-gamma involves binding of distinct factors to a palindromic response element.
Caldenhoven, E., Coffer, P. J., Yuan, J., van de Stolpe, A., Horn, F., Kruijer, W., & van der Saag, P. T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31942-7 · Cited by 117 · see citing works
Synergistic activation of intercellular adhesion molecule 1 (ICAM‐1) by TNF‐α and IFN‐γ is mediated by p65/p50 and p65/c‐Rel and interferon‐responsive factor Statlα (p91) that can be activated by both IFN‐γ and IFN‐α
Jahnke, A., & Johnson, J. P. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01130-3 · Cited by 116 · see citing works
Circulating cell adhesion molecules in bronchial lavage and serum in COPD patients with chronic bronchitis
Riise, G. C., Larsson, S., Lofdahl, C., & Andersson, B. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07091673 · Cited by 116 · see citing works
The proto-oncogene bcl-3 encodes an I kappa B protein.Preprint
Kerr, L. D., Duckett, C. S., Wamsley, P., Zhang, Q., Chiao, P. J., Nabel, G. J., McKeithan, T. W., Baeuerle, P. A., & Verma, I. M. (1992) · Genes & Development · doi:10.1101/gad.6.12a.2352 · Cited by 115 · see citing works
Glucocorticoid-mediated Repression of Intercellular Adhesion Molecule-1 Expression in Human Monocytic and Bronchial Epithelial Cell Lines
van de Stolpe, A., Caldenhoven, E., Raaijmakers, J. A. M., van der Saag, P. T., & Koenderman, L. (1993) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/8.3.340 · Cited by 114 · see citing works
Flow Stimulates ICAM-1 Expression Time and Shear Stress Dependently in Cultured Human Endothelial Cells
Tsuboi, H., Ando, J., Korenaga, R., et al. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1140 · Cited by 114 · see citing works
Adhesion molecules: a new target for immunoliposome‐mediated drug delivery
Bloemen, P. G. M., Henricks, P. A. J., van Bloois, L., et al. (1995) · FEBS Letters · doi:10.1016/0014-5793(94)01350-a · Cited by 111 · see citing works
Regulation of locomotion and cell-cell contact area by the LFA-1 and ICAM-1 adhesion receptors
Dustin, M. L., Carpén, O., & Springer, T. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.9.2654 · Cited by 110 · see citing works
Differential expression of cell adhesion molecules CD54/CD11a and CD58/CD2 by human melanoma cells and functional role in their interaction with cytotoxic cells.
Altomonte, M., Gloghini, A., Bertola, G., Gasparollo, A., Carbone, A., Ferrone, S., & Maio, M. (1993) · PubMed · Cited by 107 · see citing works
Interleukin 4 promotes expression of mast cell ICAM-1 antigen.
Valent, P., Bevec, D., Maurer, D., et al. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3339 · Cited by 107 · see citing works
Structural alterations of the NF-kappa B transcription factor lyt-10 in lymphoid malignancies.
Ns, F., Lombardi, L. T., Salina, M., et al. (1993) · PubMed · Cited by 106 · see citing works
Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease.
(1994) · PubMed Central · Cited by 105 · see citing works
The role of LFA-1/ICAM-1 interactions during murine T lymphocyte development
Fine, J. S., & Kruisbeek, A. M. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.9.2852 · Cited by 104 · see citing works
Induction and function of eosinophil intercellular adhesion molecule-1 and HLA-DR
Hansel, T. T., de Vries, I. J., Carballido, J. M., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.6.2130 · Cited by 104 · see citing works
Structural Recognition of a Novel Fibrinogen γ Chain Sequence (117 – 133) by Intercellular Adhesion Molecule-1 Mediates Leukocyte-Endothelium Interaction
Altieri, D. C., Duperray, A., Plescia, J., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.2.696 · Cited by 104 · see citing works
Regulation of expression of a human intercellular adhesion molecule (ICAM-1) during lymphohematopoietic differentiation
Boyd, A. W., Dunn, S., Fecondo, J. V., et al. (1989) · Blood · doi:10.1182/blood.v73.7.1896.1896 · Cited by 102 · see citing works
Soluble intercellular adhesion molecule 1 is released by human melanoma cells and is associated with tumor growth in nude mice.
Giavazzi, R., Chirivi, R. G. S., Garofalo, A., Rambaldi, A., Hemingway, I., Pigott, R., & Gearing, A. J. H. (1992) · PubMed · Cited by 101 · see citing works
Increased expression of CD11b and functional changes in eosinophils after migration across endothelial cell monolayers
Walker, C., Rihs, S., Braun, R., et al. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.9.4061 · Cited by 100 · see citing works
Expression of cytoadhesion molecules (CD56, CD54, CD18 and CD29) by myeloma plasma cells
Riet, I. V., Waele, M. D., Remels, L., et al. (1991) · British Journal of Haematology · doi:10.1111/j.1365-2141.1991.tb08050.x · Cited by 100 · see citing works
Regulation of the expression of ICAM-1 on human monocytes and monocytic tumor cell lines
Möst, J., Schwaeble, W., Drach, J. W., Sommerauer, A., & Dierich, M. P. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.6.1635 · Cited by 98 · see citing works
Polypeptides on human B lymphocytes associated with cell activation
Clark, E. A., Ledbetter, J. A., Holly, R. C., et al. (1986) · Human Immunology · doi:10.1016/0198-8859(86)90039-x · Cited by 98 · see citing works
Circulating Adhesion Molecules in Asthma
Montefort, S., Lai, C. K. W., Kapahi, P., et al. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.5.7513593 · Cited by 98 · see citing works
Tumor necrosis factor-alpha stimulates ICAM-1 expression in human vascular smooth muscle cells.
Couffinhal, T., Duplàa, C., Labat, L., Lamaziere, J.-M. D., Moreau, C., Printseva, O. J., & Bonnet, J. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.3.407 · Cited by 98 · see citing works
Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas
Moller, P., Henne, C., Leithäuser, F., Eichelmann, A., Schmidt, A., Brüderlein, S., Dhein, J., & Krammer, P. (1993) · Blood · doi:10.1182/blood.v81.8.2067.2067 · Cited by 98 · see citing works
Ligand intercellular adhesion molecule 1 has a necessary role in activation of integrin lymphocyte function-associated molecule 1.
Cabañas, C., & Hogg, N. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5838 · Cited by 97 · see citing works
Elevation of serum soluble intercellular adhesion molecule-1 (sICAM-1) and sE-selectin levels in bronchial asthma
Kobayashi, T., Hashimoto, S., Imai, K., et al. (1994) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1994.tb06239.x · Cited by 95 · see citing works
Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase.
Arroyo, A. G., Campanero, M. R., Sánchez‐Mateos, P., et al. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.5.1277 · Cited by 95 · see citing works
Distinct binding of T lymphocytes to ICAM‐1, ‐2 or ‐3 upon activation of LFA‐1
Binnerts, M. E., van Kooyk, Y., Simmons, D. L., et al. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240933 · Cited by 94 · see citing works
Complexity of the immediate early response of myeloid cells to terminal differentiation and growth arrest includes ICAM-1, Jun-B and histone variants.
Ka, L., Hoffman‐Liebermann, B., & Liebermann, D. A. (1990) · PubMed · Cited by 93 · see citing works
Role of Mac-1 and ICAM-1 in ischemia-reperfusion injury in a microcirculation model of BALB/C mice
Nölte, D., Hecht, R., Schmid, P., et al. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.267.4.h1320 · Cited by 91 · see citing works
Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection.
Campbell, I. L., Cutri, A., Wilkinson, D. M., Boyd, A., & Harrison, L. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.11.4282 · Cited by 91 · see citing works
Alterations at the rel locus in human lymphoma.
Lu, D., Thompson, J. D., Gk, G., et al. (1991) · PubMed · Cited by 90 · see citing works
Soluble forms of intercellular adhesion molecule-1 in insulin-dependent diabetes mellitus
Roep, B. O., de Vries, R., Heidenthal, E., Kolb, H., & Martin, S. (1994) · The Lancet · doi:10.1016/s0140-6736(94)93055-4 · Cited by 89 · see citing works
Differential expression of CD54/intercellular adhesion molecule-1 in myeloid leukemias and in lymphoproliferative disorders
Maio, M., Pinto, A., Carbone, A., et al. (1990) · Blood · doi:10.1182/blood.v76.4.783.783 · Cited by 89 · see citing works
P-selectin and ICAM-1-dependent adherence reactions: role in the genesis of postischemic no-reflow
Jerome, S. N., Doré, M., Paulson, J. C., Smith, C. W., & Korthuis, R. J. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.4.h1316 · Cited by 88 · see citing works
Intercellular adhesion molecule-1 (ICAM-1)-dependent and ICAM-1-independent adhesive interactions between polymorphonuclear leukocytes and human airway epithelial cells infected with parainfluenza virus type 2
Tosi, M. F., Stark, J. M., Hamedani, A., Smith, C. W., Gruenert, D. C., & Huang, Y. T. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.10.3345 · Cited by 87 · see citing works
Integrin LFA‐1 alpha subunit contains an ICAM‐1 binding site in domains V and VI.
Stanley, P., Bates, P. A., Harvey, J., Bennett, R. I., & Hogg, N. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06447.x · Cited by 86 · see citing works
Cross-linking of ICAM-1 induces co-signaling of an oxidative burst from mononuclear leukocytes.
Rothlein, R., Kishimoto, T. K., & Mainolfi, E. A. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.5.2488 · Cited by 86 · see citing works
Sequence and expression of rat ICAM-1
Kita, Y., Takashi, T., Iigo, Y., Tamatani, T., Miyasaka, M., & Horiuchi, T. (1992) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(92)90107-b · Cited by 86 · see citing works
Expression of leucocyte function-associated antigen-1 and 7F7-antigen, an adhesion molecule related to intercellular adhesion molecule-1 (ICAM-1) in non-Hodgkin lymphomas and leukaemias: possible influence on growth pattern and leukaemic behaviour.
Stauder, R., Greil, R., Schulz, T. F., et al. (1989) · PubMed · Cited by 85 · see citing works
ICAM-3 regulates lymphocyte morphology and integrin-mediated T cell interaction with endothelial cell and extracellular matrix ligands.
Campanero, M. R., Sánchez‐Mateos, P., del Pozo, M. Á., et al. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.3.867 · Cited by 85 · see citing works
Tumor necrosis factor induction of endothelial cell surface antigens is independent of protein kinase C activation or inactivation. Studies with phorbol myristate acetate and staurosporine
Ritchie, A. J., Johnson, D. R., Ewenstein, B. M., et al. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.9.3056 · Cited by 84 · see citing works
Human memory T cells express intercellular adhesion molecule‐1 which can be increased by interleukin 2 and interferon‐γ
Buckle, A., & Hogg, N. (1990) · European Journal of Immunology · doi:10.1002/eji.1830200216 · Cited by 84 · see citing works
Characterization of adhesive interactions between human endothelial cells and megakaryocytes.
Avraham, H. K., Cowley, S. A., Y, S., et al. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116470 · Cited by 82 · see citing works
ICAM-1 directs migration and localization of interstitial leukocytes in experimental glomerulonephritis
Hill, P. A., Lan, H. Y., Nikolic‐Paterson, D. J., et al. (1994) · Kidney International · doi:10.1038/ki.1994.4 · Cited by 81 · see citing works
Induction of Intercellular Adhesion Molecule 1 (ICAM-1) Expression in Normal Human Eosinophils by Inflammatory Cytokines
Czech, W., Krutmann, J., Budnik, A., et al. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12472082 · Cited by 81 · see citing works
Regulation of ICAM-1 expression and function in human dermal fibroblasts by IL-4
Piela-Smith, T. H., Broketa, G., Hand, A., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.5.1375 · Cited by 80 · see citing works
Strong induction of ICAM‐1 in human T cells transformed by human T‐cell‐leukemia virus type 1 and depression of ICAM‐1 or LFA‐1 in adult T‐cell‐leukemia‐derived cell lines
Fukudome, K., Furuse, M., Fukuhara, N., et al. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910520316 · Cited by 79 · see citing works
Differential role of distinct determinants of intercellular adhesion molecule-1 in immunologic phenomena.
Maio, M., Tessitori, G., Pinto, A., et al. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.1.181 · Cited by 78 · see citing works
Inflammation and cell-cell interactions in airway hyperresponsiveness
Leff, A. R., Hamann, K. J., & Wegner, C. D. (1991) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1991.260.4.l189 · Cited by 78 · see citing works
Stimulation of human naive and memory T helper cells with bacterial superantigen. Naive CD4+45RA+ T cells require a costimulatory signal mediated through the LFA-1/ICAM-1 pathway
Fischer, H., Gjörloff, A., Hedlund, G., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.1993 · Cited by 77 · see citing works
Structural Characteristics of the 5′ Region of the Human ICAM-1 Gene
Stade, B. G., Messer, G., Riethmüller, G., & Johnson, J. P. (1990) · Immunobiology · doi:10.1016/s0171-2985(11)80585-1 · Cited by 77 · see citing works
Clinical relevance of ICAM-1 expression in primary lesions and serum of patients with malignant melanoma.
Kageshita, T., Yoshii, A., Kimura, T., et al. (1993) · PubMed · Cited by 76 · see citing works
Induction of VCAM-1 and ICAM-1 on human neural cells and mechanisms of mononuclear leukocyte adherence
Birdsall, H. H., Lane, C. L., Ramser, M., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.9.2717 · Cited by 75 · see citing works
Expression of cell adhesion molecules in human melanoma cell lines and their role in cytotoxicity mediated by tumor‐infiltrating lymphocytes
Pandolfi, F., Trentin, L., Boyle, L. A., et al. (1992) · Cancer · doi:10.1002/cncr.2820690517 · Cited by 74 · see citing works
Increased levels of intercellular adhesion molecule‐1 (ICAM‐1) and tumor necrosis factor receptor in the cerebrospinal fluid of patients with multiple sclerosis
Tsukada, N., Matsuda, M., Miyagi, K., & Yanagisawa, N. (1993) · Neurology · doi:10.1212/wnl.43.12.2679 · Cited by 74 · see citing works
Involvement of adhesion molecules LFA-1 and ICAM-1 in osteoclast development
Kurachi, T., Morita, I., & Murota, S. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(93)90202-z · Cited by 70 · see citing works

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Authors: van de Stolpe, A., & van der Saag, P. T.
Venue: Journal of Molecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 1996-01
Volume: 74
Issue: 1
Pages: 13-33
ISSN: 0946-2716 (ISSN-L)
1432-1440
DOI: 10.1007/bf00202069
OpenAlex: W1530203607
Cited by: 802
References: 319
Citations by year: 2026: 6 · 2025: 12 · 2024: 17 · 2023: 23 · 2022: 23 · 2021: 22 · 2020: 6 · 2019: 13 · 2018: 10 · 2017: 14 · 2016: 21 · 2015: 23 · 2014: 28 · 2013: 32 · 2012: 34
FWCI: 11.71
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords: ICAM-1, soluble ICAM-1, adhesion molecules, integrins, LFA-1, Mac-1, cytokine induction, transcriptional regulation, leukocyte migration, T cell costimulation, inflammation, rhinovirus infection, melanoma, lymphoma, autoimmune disease, atherosclerosis, organ transplantation
MeSH terms: Animals, Base Sequence, Cell Adhesion, DNA, Forecasting, Gene Expression Regulation, Humans, Leukocytes, Ligands, Molecular Sequence Data, Molecular Structure, Intercellular Adhesion Molecule-1

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Intercellular adhesion molecule-1

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