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Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells.
Open accessAbstract
Human IL-1, recombinant murine IL-1 and E. coli LPS were found to be potent inducers of plasminogen activator (PA)-inhibitor activity, both in vivo, in rats, as well as in cultured human endothelial cells. In vivo, LPS rapidly and dose-dependently (0.01-1,000 micrograms/kg) increased plasma PA-inhibitor activity. Infusion of IL-1 into rats resulted in a small but significant increase in PA-inhibitor activity in rat plasma. Likewise, in cultured human umbilical vein endothelial cells, LPS and IL-1 induced increased synthesis of PA-inhibitor. We suggest that the induced rat plasma inhibitor might be of endothelial origin.
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Metadata
- Authors
- Emeis, J. J., & Kooistra, T.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1986-05-01
- Volume
- 163
- Issue
- 5
- Pages
- 1260-1266
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2152088076
- Cited by
- 410
- References
- 0
- FWCI
- 20.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells. https://app.cochat.ai/papers/10.1084/jem.163.5.1260
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- Emeis, J. J., & Kooistra, T. (1986). Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells. The Journal of experimental medicine. https://doi.org/10.1084/jem.163.5.1260
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
