The Metabolic Syndrome and Inflammation

Sutherland, Julie P.; McKinley, Benjamin; Eckel, Robert H.

doi:10.1089/met.2004.2.82

Cited by 243Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Disease and Adiposity

The Metabolic Syndrome and Inflammation

Sutherland, Julie P., McKinley, Benjamin, Eckel, Robert H.·2004·Metabolic Syndrome and Related Disorders

DOI 10.1089/met.2004.2.82

Open this paper in CoChat — free account

Abstract

The metabolic syndrome (MS) is a clustering of cardiovascular risk factors, with insulin resistance as a major feature. This syndrome has been variously defined, but generally consists of 3 or more of the following components: hyperglycemia, hypertension, hypertriglyceridemia, low HDL, and increased abdominal circumference and/or BMI at >30 kg/m(2). The WHO criteria require the presence of insulin resistance to make the diagnosis. The current review focuses particularly on the association of the MS and the proinflammatory state as well as treatment options to prevent the development of coronary heart disease (CHD). Chronic inflammation is frequently associated with the MS. Inflammatory markers that have been associated with MS include hs-CRP, TNF-alpha, fibrinogen, and IL-6, among others. The link between inflammation and the MS is not fully understood. One postulated mechanism is that these cytokines are released into the circulation by adipose tissue, stimulating hepatic CRP production. The prothrombotic molecule PAI-1 is also increased in the MS. Adiponectin, produced exclusively by adipocytes, is decreased in obesity. The association of these proinflammatory and prothrombotic markers with the MS is discussed in detail. The general goals of treatment of the MS are prevention of CHD events and diabetes if not already present. The approach to treatment of those with the MS should include lifestyle changes, including weight loss and exercise as well as appropriate pharmacological therapies. Certain medications, which may be used in persons with MS, have been shown to have beneficial effects on clinical outcome and/or anti-inflammatory effects.

Integrity signals

Registry

Crossref · 10.1089/met.2004.2.82

Cites

240 of 240 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Several studies have confirmed an association between CRP, IL-6 and TNF-α with the metabolic syndrome.
“Several studies have confirmed an association between CRP, IL-6 and TNF-α with the metabolic syndrome”
From Association of depressive disorders, depression characteristics and antidepressant medication with inflammation (2012) · cites this paper as [30]
Visceral fat depots release cytokines.
“visceral fat depots release cytokines.30”
From Association of depressive disorders, depression characteristics and antidepressant medication with inflammation (2012) · cites this paper as [30]

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011 · see citing works
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154 · see citing works
Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance
Tuomilehto, J., Lindström, J., Eriksson, J. G., Valle, T. T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Louheranta, A., Rastas, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105033441801 · Cited by 10,873 · cited 2× · see citing works
“The Finnish Diabetes Prevention Study and the Diabetes Prevention Program 140,141 showed that even modest weight reductions ( (cid:1) 5”
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420301 · Cited by 8,663 · see citing works
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493 · cited 1× · see citing works
“214 Thus, while there is evidence that blockade of the RAS reduces inflammatory markers and increases adiponectin, the mechanism of these effects is unclear.”
Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia
Shepherd, J., Cobbe, S. M., Ford, I., Isles, C. G., Lorimer, A. R., Macfarlane, P. W., McKillop, J. H., & Packard, C. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511163332001 · Cited by 7,449 · see citing works
MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebocontrolled trial
(2002) · The Lancet · doi:10.1016/s0140-6736(02)09327-3 · Cited by 6,992 · see citing works
Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, H. B., Clark, L. T., Hunninghake, D. B., Pasternak, R. C., Smith, S. C., & Stone, N. J. (2004) · Circulation · doi:10.1161/01.cir.0000133317.49796.0e · Cited by 6,902 · see citing works
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504 · see citing works
Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels
(1998) · New England Journal of Medicine · doi:10.1056/nejm199811053391902 · Cited by 5,261 · see citing works
Primary Prevention of Acute Coronary Events With Lovastatin in Men and Women With Average Cholesterol Levels: Results of AFCAPS/TexCAPS
Downs, J. R., Clearfield, M., Weis, S., Whitney, E., Shapiro, D. R., Beere, P. A., Langendorfer, A., Stein, E. A., Kruyer, W., Gotto, Jr., et al. (1998) · JAMA · doi:10.1001/jama.279.20.1615 · Cited by 5,236 · see citing works
The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
Lakka, H.-M. (2002) · JAMA · doi:10.1001/jama.288.21.2709 · Cited by 5,033 · see citing works
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622 · see citing works
Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease
DeFronzo, R. A., & Ferrannini, E. (1991) · Diabetes Care · doi:10.2337/diacare.14.3.173 · Cited by 4,555 · see citing works
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433 · see citing works
Collaborative overview of randomised trials of antiplatelet therapy Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients
Altman, R., Carreras, L., Díaz, R. S., Figueroa, E. B., Paolasso, E., Parodi, J. C., Cade, J. F., Donnan, G. A., Eadie, M. J., Gavaghan, T. P., et al. (1994) · BMJ · doi:10.1136/bmj.308.6921.81 · Cited by 4,198 · see citing works
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801 · see citing works
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
Ridker, P. M., Rifai, N., Rose, L., Buring, J. E., & Cook, N. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021993 · Cited by 3,604 · see citing works
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543 · see citing works
Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia
Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541 · see citing works
Gemfibrozil for the Secondary Prevention of Coronary Heart Disease in Men with Low Levels of High-Density Lipoprotein Cholesterol
Rubins, H. B., Robins, S. J., Collins, D., Fye, C. L., Anderson, J. W., Elam, M. B., Faas, F. H., Linares, E., Schaefer, E. J., Schectman, G., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908053410604 · Cited by 3,439 · see citing works
COLLABORATIVE OVERVIEW OF RANDOMIZED TRIALS OF ANTIPLATELET THERAPY .1. PREVENTION OF DEATH, MYOCARDIAL-INFARCTION, AND STROKE BY PROLONGED ANTIPLATELET THERAPY IN VARIOUS CATEGORIES OF PATIENTS
Altman, R., Carreras, L., Díaz, R. S., Figueroa, E. B., Paolasso, E., Parodi, J. C., Cade, J. F., Donnan, G. A., Eadie, M. J., Gavaghan, T. P., et al. (1994) · Cited by 3,322 · see citing works
Self-citation
Plasma Concentrations of a Novel, Adipose-Specific Protein, Adiponectin, in Type 2 Diabetic Patients
Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1595 · Cited by 3,133 · see citing works
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899 · see citing works
EFFECTS OF CHANGES IN FAT, FISH, AND FIBRE INTAKES ON DEATH AND MYOCARDIAL REINFARCTION: DIET AND REINFARCTION TRIAL (DART)
Burr, M. L., Gilbert, J. F., Holliday, R. M., Elwood, P. C., Fehily, A. M., Rogers, S., Sweetnam, P. M., & Deadman, N. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90828-3 · Cited by 2,610 · see citing works
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526 · see citing works
Clinical application of C-reactive protein for cardiovascular disease detection and prevention
Ridker, P. M. (2003) · Circulation · doi:10.1161/01.cir.0000053730.47739.3c · Cited by 2,513 · see citing works
C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?
Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465 · see citing works
Plasma Concentration of Interleukin-6 and the Risk of Future Myocardial Infarction Among Apparently Healthy Men
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429 · see citing works
Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome
Festa, A., D’Agostino, R., Howard, G., Mykkänen, L. M., Tracy, R. P., & Haffner, S. M. (2000) · Circulation · doi:10.1161/01.cir.102.1.42 · Cited by 2,363 · see citing works
Effect of Intensive Compared With Moderate Lipid-Lowering Therapy on Progression of Coronary Atherosclerosis
Nissen, S. E., Tuzcu, E. M., Schoenhagen, P., Brown, B. G., Ganz, P., Vogel, R. A., Crowe, T., Howard, G., Cooper, C. J., Brodie, B. R., et al. (2004) · JAMA · doi:10.1001/jama.291.9.1071 · Cited by 2,358 · see citing works
Final Report on the Aspirin Component of the Ongoing Physicians' Health Study
Steering Committee of the Physicians' Health Study Research Group (1989) · New England Journal of Medicine · doi:10.1056/nejm198907203210301 · Cited by 2,269 · see citing works
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234 · see citing works
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,074 · see citing works
Association of Fibrinogen, C-reactive Protein, Albumin, or Leukocyte Count With Coronary Heart Disease
Danesh, J., Collins, R., Appleby, P. N., & Peto, R. (1998) · JAMA · doi:10.1001/jama.279.18.1477 · Cited by 2,027 · see citing works
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α,in Vivo1
Mohamed‐Ali, V., Goodrick, S., Rawesh, A., Katz, D. R., Miles, J. M., Yudkin, J. S., Klein, S., & Coppack, S. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4450 · Cited by 2,012 · see citing works
AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update
Pearson, T. A., Blair, S. N., Daniels, S. R., Eckel, R. H., Fair, J. M., Fortmann, S. P., Franklin, B. A., Goldstein, L. B., Greenland, P., Grundy, S. M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000020190.45892.75 · Cited by 1,852 · see citing works
Self-citation
Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris
Thompson, S. G., Kienast, J., Pyke, S., Haverkate, F., & van de Loo, J. C. W. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321003 · Cited by 1,819 · see citing works
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
Pischon, T. (2004) · JAMA · doi:10.1001/jama.291.14.1730 · Cited by 1,762 · see citing works
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
Jiang, J., & Struhl, G. (1998) · Nature · doi:10.1038/35154 · Cited by 1,735 · see citing works
PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein
Maeda, N., Takahashi, M., Funahashi, T., Kihara, S., Nishizawa, H., Kishida, K., Nagaretani, H., Matsuda, M., Komuro, R., Ouchi, N., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2094 · Cited by 1,659 · see citing works
The Deadly Quartet
Kaplan, N. M. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.7.1514 · Cited by 1,658 · see citing works
Cholesterol Lowering With Simvastatin Improves Prognosis of Diabetic Patients With Coronary Heart Disease: A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S)
Pyörälä, K., Pedersen, T. R., Kjekshus, J., Faergeman, O., Olsson, A. G., Thorgeirsson, G., & The Scandinavian Simvastatin Survival Study (4S) Group (1997) · Diabetes Care · doi:10.2337/diacare.20.4.614 · Cited by 1,623 · see citing works
Immune-neuro-endocrine interactions: facts and hypotheses.
BESEDOVSKY, H. O., & REY, A. D. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-1-64 · Cited by 1,564 · see citing works
West of Scotland Coronary Prevention Study: identification of high-risk groups and comparison with other cardiovascular intervention trials
(1996) · The Lancet · doi:10.1016/s0140-6736(96)04292-4 · Cited by 1,564 · see citing works
Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
Ridker, P. M., Rifai, N., Clearfield, M., Downs, J. R., Weis, S. E., Miles, J. S., & Gotto, A. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106283442601 · Cited by 1,557 · see citing works
Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid 1
Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,528 · see citing works
Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women: A Randomized Trial
Esposito, K., Pontillo, A., Di Palo, C., Giugliano, G., Masella, M., Marfella, R., & Giugliano, D. (2003) · JAMA · doi:10.1001/jama.289.14.1799 · Cited by 1,511 · see citing works
Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
Cnop, M., Havel, P. J., Utzschneider, K. M., Carr, D. B., Sinha, M. K., Boyko, E. J., Retzlaff, B. M., Knopp, R. H., Brunzell, J. D., & Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-003-1074-z · Cited by 1,483 · see citing works
PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION
Hamsten, A., Walldius, G., Szamosi, A., Blombäck, M., de Faire, U., Dahlén, G. H., Landou, C., & Wiman, B. (1987) · The Lancet · doi:10.1016/s0140-6736(87)93050-9 · Cited by 1,474 · see citing works
Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link
Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diab.43.11.1271 · Cited by 1,344 · see citing works
Increased Plasma Levels of a Rapid Inhibitor of Tissue Plasminogen Activator in Young Survivors of Myocardial Infarction
Hamsten, A., Wiman, B., Fairé, U. D., & Blombäck, M. (1985) · New England Journal of Medicine · doi:10.1056/nejm198512193132501 · Cited by 1,339 · see citing works
Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction: Time-Course Analysis of the Results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione
Marchioli, R., Barzi, F., Bomba, E., Chieffo, C., Di Gregorio, D., Di Mascio, R., Franzosi, M. G., Geraci, E., Levantesi, G., Maggioni, A. P., et al. (2002) · Circulation · doi:10.1161/01.cir.0000014682.14181.f2 · Cited by 1,311 · see citing works
The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305 · see citing works
Secondary Prevention by Raising HDL Cholesterol and Reducing Triglycerides in Patients With Coronary Artery Disease: The Bezafibrate Infarction Prevention (BIP) Study
(2000) · Circulation · doi:10.1161/01.cir.102.1.21 · Cited by 1,273 · see citing works
Prospective Analysis of The Insulin-Resistance Syndrome (Syndrome X)
Haffner, S. M., Valdez, R. A., Hazuda, H. P., Mitchell, B. D., Morales, P. A., & D, M. P. S. M. (1992) · Diabetes · doi:10.2337/diab.41.6.715 · Cited by 1,234 · see citing works
NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X
Pickup, J. C., Mattock, M. B., Chusney, G. D., & Burt, D. J. (1997) · Diabetologia · doi:10.1007/s001250050822 · Cited by 1,231 · see citing works
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation
Kubota, N., Terauchi, Y., Yamauchi, T., Kubota, T., Moroi, M., Matsui, J., Eto, K., Yamashita, T., Kamon, J., Satoh, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200251200 · Cited by 1,213 · see citing works
Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin
Yang, W.-S., Lee, W.-J., Funahashi, T., Tanaka, S., Matsuzawa, Y., Chao, C.-L., Chen, C.-L., Tai, T.-Y., & Chuang, L.-M. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.8.3815 · Cited by 1,181 · see citing works
The Pathophysiologic Roles of Interleukin-6 in Human Disease
Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00009 · Cited by 1,146 · see citing works
Blood Levels of Long-Chain n–3 Fatty Acids and the Risk of Sudden Death
Albert, C. M., Campos, H., Stampfer, M. J., Ridker, P. M., Manson, J. E., Willett, W. C., & Ma, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012918 · Cited by 1,146 · see citing works
Omental and Subcutaneous Adipose Tissues of Obese Subjects Release Interleukin-6: Depot Difference and Regulation by Glucocorticoid
Fried, S. K. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.847 · Cited by 1,146 · see citing works
Prevalence of the Metabolic Syndrome and Its Relation to All-Cause and Cardiovascular Mortality in Nondiabetic European Men and Women
Hu, G. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.10.1066 · Cited by 1,135 · see citing works
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
Staels, B., Köenig, W., Habib, A., Merval, R., Lebret, M., Pineda‐Torra, I., Delerive, P., Fadel, A., Chinetti, G., Fruchart, J., et al. (1998) · Nature · doi:10.1038/31701 · Cited by 1,134 · see citing works
Disruption of adiponectin causes insulin resistance and neointimal formation
Froguel, P. (2002) · HAL · Cited by 1,126 · see citing works
Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss
Bastard, J., Jardel, C., Bruckert, É., Blondy, P., Capeau, J., Laville, M., Vidal, H., & Hainque, B. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6839 · Cited by 1,102 · see citing works
Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys
Hotta, K., Funahashi, T., Bodkin, N. L., Ortmeyer, H. K., Arita, Y., Hansen, B. C., & Matsuzawa, Y. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1126 · Cited by 1,072 · see citing works
Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study
Schmidt, M. I., Duncan, B. B., Sharrett, A. R., Lindberg, G., Savage, P. J., Offenbacher, S., Azambuja, M. I. R., Tracy, R. P., & HEISS, G. M. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01046-6 · Cited by 1,069 · see citing works
American College of Endocrinology Position Statement on the Insulin Resistance Syndrome
Einhorn, D. (2003) · Endocrine Practice · doi:10.4158/ep.9.s2.5 · Cited by 1,066 · see citing works
Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes
Festa, A., D’Agostino, R., Tracy, R. P., & Haffner, S. M. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1131 · Cited by 1,057 · see citing works
C-Reactive Protein Adds to the Predictive Value of Total and HDL Cholesterol in Determining Risk of First Myocardial Infarction
Ridker, P. M., Glynn, R. J., & Hennekens, C. H. (1998) · Circulation · doi:10.1161/01.cir.97.20.2007 · Cited by 1,012 · see citing works
C-Reactive Protein and the Risk of Developing Hypertension
Sesso, H. D. (2003) · JAMA · doi:10.1001/jama.290.22.2945 · Cited by 1,005 · see citing works
Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes
Saltiel, A. R., & Olefsky, J. M. (1996) · Diabetes · doi:10.2337/diab.45.12.1661 · Cited by 1,001 · see citing works
Inflammatory Markers and Onset of Cardiovascular Events: Results From the Health ABC Study
Cesari, M., Penninx, B. W. J. H., Newman, A. B., Kritchevsky, S. B., Nicklas, B. J., Sutton-Tyrrell, K., Rubin, S. M., Ding, J., Simonsick, E. M., Harris, T. B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000097109.90783.fc · Cited by 978 · see citing works
Elevation of Plasma Cytokines in Disorders of Excessive Daytime Sleepiness: Role of Sleep Disturbance and Obesity
Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Kales, A., Tyson, K., & Chrousos, G. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3950 · Cited by 974 · see citing works
Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone
Nolan, J. J., Ludvik, B. H., Beerdsen, P., Joyce, M., & Olefsky, J. M. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411033311803 · Cited by 925 · see citing works
Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest.
Siscovick, D. S. (1995) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1995.03530170043030 · Cited by 920 · see citing works
Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty
Shimomura, I., Funahasm, T., Takahashi, M., Maeda, K., Kotani, K., Nakamura, T., Yamashita, S., Miura, M., Fukuda, Y., Takemura, K., et al. (1996) · Nature Medicine · doi:10.1038/nm0796-800 · Cited by 890 · see citing works
Effect of Rosiglitazone Treatment on Nontraditional Markers of Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus
Haffner, S. M., Greenberg, A. S., Weston, W. M., Chen, H., Williams, K., & Freed, M. I. (2002) · Circulation · doi:10.1161/01.cir.0000025403.20953.23 · Cited by 882 · see citing works
Adiponectin Expression From Human Adipose Tissue
Kern, P. A., Di Gregorio, G. B., Lu, T., Rassouli, N., & Ranganathan, G. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1779 · Cited by 875 · see citing works
The Deadly Quartet
Kaplan, N. M. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.1989.00390070054005 · Cited by 842 · see citing works
C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor
Čermák, J., Key, N., Bach, R., Balla, J., Jacob, H., & Vercellotti, G. (1993) · Blood · doi:10.1182/blood.v82.2.513.513 · Cited by 838 · see citing works
The Effects of Low-Carbohydrate versus Conventional Weight Loss Diets in Severely Obese Adults: One-Year Follow-up of a Randomized Trial
Stern, L., Iqbal, N., Seshadri, P., Chicano, K. L., Daily, D. A., McGrory, J., Williams, M., Gracely, E. J., & Samaha, F. F. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-10-200405180-00007 · Cited by 831 · see citing works
Association of the Metabolic Syndrome With History of Myocardial Infarction and Stroke in the Third National Health and Nutrition Examination Survey
Ninomiya, J. K., L'Italien, G. J., Criqui, M. H., Whyte, J. L., Gamst, A. C., & Chen, R. S. (2003) · Circulation · doi:10.1161/01.cir.0000108926.04022.0c · Cited by 793 · see citing works
Effect of Hydroxymethyl Glutaryl Coenzyme A Reductase Inhibitor Therapy on High Sensitive C-Reactive Protein Levels
Jialal, I., Stein, D. T., Balis, D. S., Grundy, S. M., ADAMS-HUET, B. A., & Devaraj, S. (2001) · Circulation · doi:10.1161/01.cir.103.15.1933 · Cited by 729 · see citing works
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor- , in Vivo
Mohamed-Ali, V. (1997) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.12.4196 · Cited by 717 · see citing works
Blood Pressure and Inflammation in Apparently Healthy Men
Chae, C. U., Lee, R. T., Rifai, N., & Ridker, P. M. (2001) · Hypertension · doi:10.1161/01.hyp.38.3.399 · Cited by 716 · see citing works
Insulin Inhibits Intranuclear Nuclear Factor B and Stimulates I B in Mononuclear Cells in Obese Subjects: Evidence for an Anti-inflammatory Effect?
Dandona, P., Aljada, A., Mohanty, P., Ghanim, H., Hamouda, W., Assian, E., & Ahmad, S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7623 · Cited by 695 · see citing works
Association between C-reactive protein and features of the metabolic syndrome: a population-based study.
Fröhlich, M., Imhof, A., Berg‐Beckhoff, G., Hutchinson, W. L., Pepys, M. B., Boeing, H., Muche, R., Brenner, H., & Köenig, W. (2000) · Diabetes Care · doi:10.2337/diacare.23.12.1835 · Cited by 683 · see citing works
C-Reactive Protein Increases Plasminogen Activator Inhibitor-1 Expression and Activity in Human Aortic Endothelial Cells
Devaraj, S., Xu, D. Y., & Jialal, I. (2003) · Circulation · doi:10.1161/01.cir.0000052617.91920.fd · Cited by 641 · see citing works
The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: One-year follow-up of a randomized trial
Stem, L., Iqbal, N., Seshadri, P., & Chicano, K. L. (2004) · ACC Current Journal Review · doi:10.1016/j.accreview.2004.07.103 · Cited by 629 · see citing works
Adipose Tissue IL-6 Content Correlates with Resistance to Insulin Activation of Glucose Uptake both in Vivo and in Vitro
Bastard, J., Maachi, M., Nhieu, J. T. V., Jardel, C., Bruckert, É., Grimaldi, A., Robert, J., Capeau, J., & Hainque, B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8450 · Cited by 625 · see citing works
Production of Plasminogen Activator Inhibitor 1 by Human Adipose Tissue: Possible Link Between Visceral Fat Accumulation and Vascular Disease
Alessi, M., Peiretti, F., Morange, P., Henry, M., Nalbone, G., & Juhan-Vague, I. (1997) · Diabetes · doi:10.2337/diab.46.5.860 · Cited by 614 · see citing works
Peroxisome Proliferator–Activated Receptor γ and Metabolic Disease
Willson, T. M., Lambert, M. H., & Kliewer, S. A. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.341 · Cited by 582 · see citing works
Does Exercise Reduce Inflammation? Physical Activity and C-Reactive Protein Among U.S. Adults
Ford, E. S. (2002) · Epidemiology · doi:10.1097/00001648-200209000-00012 · Cited by 575 · see citing works
Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women
Fernandez-Real, J.-M., Vayreda, M., Richart, C., Gutierrez, C., Broch, M., Vendrell, J., & Ricart, W. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7305 · Cited by 567 · see citing works
Increased plasma plasminogen activator inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis
Juhan-Vague, I., Alessi, M., & Vague, P. (1991) · Diabetologia · doi:10.1007/bf00403280 · Cited by 566 · see citing works
Plasma Adiponectin Concentration Is Associated With Skeletal Muscle Insulin Receptor Tyrosine Phosphorylation, and Low Plasma Concentration Precedes a Decrease in Whole-Body Insulin Sensitivity in Humans
Stefan, N., Vozarova, B., Funahashi, T., Matsuzawa, Y., Weyer, C., Lindsay, R. S., YOUNGREN, J. F., Havel, P. J., Pratley, R. E., Bogardus, C., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1884 · Cited by 557 · see citing works
Relationship Between Interleukin 6 and Mortality in Patients With Unstable Coronary Artery Disease
Lindmark, E., Diderholm, E., Wallentin, L. C., & Siegbahn, A. (2001) · JAMA · doi:10.1001/jama.286.17.2107 · Cited by 557 · see citing works
Fibrinolytic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients With Angina Pectoris
Juhan-Vague, I., Pyke, S., Alessi, M., Jespersen, J., Haverkate, F., & Thompson, S. G. (1996) · Circulation · doi:10.1161/01.cir.94.9.2057 · Cited by 551 · see citing works
Emerging Risk Factors for Atherosclerotic Vascular Disease
Hackam, D. G., & Anand, S. S. (2003) · JAMA · doi:10.1001/jama.290.7.932 · Cited by 548 · see citing works
Weight Loss Reduces C-Reactive Protein Levels in Obese Postmenopausal Women
Tchernof, A., Nolan, A., Sites, C. K., Ades, P. A., & Poehlman, E. T. (2002) · Circulation · doi:10.1161/hc0502.103331 · Cited by 541 · see citing works
The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly
Barzilay, J. I., Abraham, L., Heckbert, S. R., Cushman, M., Kuller, L. H., Resnick, H. E., & Tracy, R. P. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2384 · Cited by 541 · see citing works
Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes
Faßhauer, M., Kralisch, S., Klier, M., Lössner, U., Blüher, M., Klein, J. C., & Paschke, R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00090-1 · Cited by 534 · see citing works
Adipocytokines and Insulin Resistance
Pittas, A. G., Joseph, N. A., & Greenberg, A. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031005 · Cited by 515 · see citing works
Prospective Study of C-Reactive Protein in Relation to the Development of Diabetes and Metabolic Syndrome in the Mexico City Diabetes Study
Han, T. S., Sattar, N. A., Williams, K., González‐Villalpando, C., Lean, M. E. J., & Haffner, S. M. (2002) · Diabetes Care · doi:10.2337/diacare.25.11.2016 · Cited by 514 · see citing works
The Effect of Dietary ω-3 Fatty Acids on Coronary Atherosclerosis
von Schacky, C., Angerer, P., Kothny, W., Theisen, K., & Mudra, H. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-7-199904060-00003 · Cited by 487 · see citing works
Increasing Levels of Interleukin (IL)-1Ra and IL-6 During the First 2 Days of Hospitalization in Unstable Angina Are Associated With Increased Risk of In-Hospital Coronary Events
Biasucci, L. M., Liuzzo, G., Fantuzzi, G., Caligiuri, G., Rebuzzi, A. G., Ginnetti, F., Dinarello, C. A., & Maseri, A. (1999) · Circulation · doi:10.1161/01.cir.99.16.2079 · Cited by 484 · see citing works
Components of the Metabolic Syndrome and Risk of Cardiovascular Disease and Diabetes in Beaver Dam
Klein, R., Klein, R., & Lee, K. E. (2002) · Diabetes Care · doi:10.2337/diacare.25.10.1790 · Cited by 463 · see citing works
Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension
Furuhashi, M., Ura, N., Higashiura, K., Murakami, H., Tanaka, M., Moniwa, N., Yoshida, D., & Shimamoto, K. (2003) · Hypertension · doi:10.1161/01.hyp.0000078490.59735.6e · Cited by 460 · see citing works
Correlation between blood fibrinolytic activity, plasminogen activator inhibitor level, plasma insulin level, and relative body weight in normal and obese subjects
Vague, P., Juhan-Vague, I., Aillaud, M. F., Badier, C., Viard, R., Alessi, M., & Collen, D. (1986) · Metabolism · doi:10.1016/0026-0495(86)90209-x · Cited by 443 · see citing works
Angiographic assessment of effects of bezafibrate on progression of coronary artery disease in young male postinfarction patients
Ericsson, C.-G., Fairé, U. D., Grip, L., Svane, B., Hamsten, A., & Nilsson, J. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91343-4 · Cited by 438 · see citing works
Insulin Resistance, the Metabolic Syndrome, and Risk of Incident Cardiovascular Disease in Nondiabetic American Indians
Resnick, H. E., Jones, K. L., Ruotolo, G., Jain, A. K., Henderson, J. A., Lu, W., & Howard, B. V. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.861 · Cited by 427 · see citing works
Impact of Weight Loss on Inflammatory Proteins and Their Association With the Insulin Resistance Syndrome in Morbidly Obese Patients
Kopp, H. P., Kopp, C. W., Festa, A., Krzyzanowska, K., Kriwanek, S., Minar, E., Roka, R., & Schernthaner, G. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000073313.16135.21 · Cited by 427 · cited 2× · see citing works
“32 Studies over the past decade have shown that the storage and release of FFAs by adipose tissue are not its only function.”
Association between adiponectin and mediators of inflammation in obese women
Engeli, S., Feldpausch, M., Gorzelniak, K., Hartwig, F., Heintze, U., Janke, J., Möhlig, M., Pfeiffer, A. F. H., Luft, F. C., & Sharma, A. M. (2003) · Diabetes · doi:10.2337/diabetes.52.4.942 · Cited by 422 · see citing works
Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells.
Emeis, J. J., & Kooistra, T. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.163.5.1260 · Cited by 421 · see citing works
Angiographic Assessment of Effects of Bezafibrate on Progression of Coronary Artery Disease in Young Male Postinfarction Patients
&NA; (1996) · The Endocrinologist · doi:10.1097/00019616-199609000-00019 · Cited by 417 · see citing works
Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta.
Sawdey, M., & Loskutoff, D. J. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115440 · Cited by 413 · see citing works
Pleiotropic Actions of Peroxisome Proliferator–Activated Receptors in Lipid Metabolism and Atherosclerosis
Barbier, O., Pineda‐Torra, I., Duguay, Y., Blanquart, C., Fruchart, J., Glineur, C., & Staels, B. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000015598.86369.04 · Cited by 412 · see citing works
Nonhypoglycemic Effects of Thiazolidinediones
Parulkar, A., Pendergrass, M., Granda-Ayala, R., Lee, T. R., & Fonseca, V. A. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-1-200101020-00014 · Cited by 410 · see citing works
High-Dose Atorvastatin Enhances the Decline in Inflammatory Markers in Patients With Acute Coronary Syndromes in the MIRACL Study
Kinlay, S., Schwartz, G. G., OLSSON, A. G., Rifai, N., Leslie, S. J., Sasiela, W. J., Szarek, M. J., Libby, P., & Ganz, P. (2003) · Circulation · doi:10.1161/01.cir.0000091404.09558.af · Cited by 403 · see citing works
Risk of new-onset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study
Lindholm, L. H., Ibsen, H., Borch-Johnsen, K., Olsen, M. H., Wachtell, K., Dahlöf, B., Devereux, R. B., Beevers, G., de Faire, U., Fyhrquist, F., et al. (2002) · Journal of Hypertension · doi:10.1097/00004872-200209000-00035 · Cited by 392 · see citing works
Simvastatin Reduces Expression of Cytokines Interleukin-6, Interleukin-8, and Monocyte Chemoattractant Protein-1 in Circulating Monocytes From Hypercholesterolemic Patients
Rezaie-Majd, A., Maca, T., Bucek, R. A., Valent, P., Müller, M. R., Husslein, P. W., Kashanipour, A., Minar, E., & Baghestanian, M. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000022694.16328.cc · Cited by 380 · see citing works
Evidence for a Potent Antiinflammatory Effect of Rosiglitazone
Mohanty, P., Aljada, A., Ghanim, H., Hofmeyer, D., Tripathy, D., Syed, T., Al-Haddad, W., Dhindsa, S., & Dandona, P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032103 · Cited by 375 · see citing works
Differentiation Between Obesity and Insulin Resistance in the Association With C-Reactive Protein
McLaughlin, T., Abbasi, F., Lamendola, C. A., Liang, L., Reaven, G. M., Schaaf, P., & Reaven, P. D. (2002) · Circulation · doi:10.1161/01.cir.0000041046.32962.86 · Cited by 374 · see citing works
Tumor necrosis factor alpha: a key component of the obesity-diabetes link
Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diabetes.43.11.1271 · Cited by 354 · see citing works
Simvastatin Lowers C-Reactive Protein Within 14 Days
Plenge, J. K., Hernandez, T. L., Weil, K. M., Poirier, P., Grunwald, G. K., Marcovina, S. M., & Eckel, R. H. (2002) · Circulation · doi:10.1161/01.cir.0000029743.68247.31 · Cited by 351 · see citing works
Self-citation
Abdominal obesity is associated with an impaired fibrinolytic activity and elevated plasminogen activator inhibitor-1
Landin‐Wilhelmsen, K., Stigendal, L., Eriksson, E., Krotkiewski, M., Risberg, B., Tengborn, L., & Smith, U. (1990) · Metabolism · doi:10.1016/0026-0495(90)90164-8 · Cited by 341 · see citing works
Involvement of the hemostatic system in the insulin resistance syndrome. A study of 1500 patients with angina pectoris. The ECAT Angina Pectoris Study Group.
Juhan-Vague, I., Thompson, S. G., & Jespersen, J. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.12.1865 · Cited by 326 · see citing works
The metabolic syndrome and C-reactive protein, fibrinogen, and leukocyte count: findings from the Third National Health and Nutrition Examination Survey
Ford, E. S. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00134-5 · Cited by 315 · see citing works
Factors Responsible for Impaired Fibrinolysis in Obese Subjects and NIDDM Patients
McGill, J. B., Schneider, D. J., Arfken, C. L., Lucore, C. L., & Sobel, B. E. (1994) · Diabetes · doi:10.2337/diab.43.1.104 · Cited by 310 · see citing works
Fish Oil–Derived Fatty Acids, Docosahexaenoic Acid and Docosapentaenoic Acid, and the Risk of Acute Coronary Events
Rissanen, T., Voutilainen, S., Nyyssönen, K., Lakka, T. A., & Salonen, J. T. (2000) · Circulation · doi:10.1161/01.cir.102.22.2677 · Cited by 306 · see citing works
Measuring Plasma Fibrinogen to Predict Stroke and Myocardial Infarction
Maresca, G., Blasio, A. D., Marchioli, R., & Minno, G. D. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.6.1368 · Cited by 305 · see citing works
Thiazolidinediones in the treatment of insulin resistance and type II diabetes
Saltiel, A. R., & Olefsky, J. M. (1996) · Diabetes · doi:10.2337/diabetes.45.12.1661 · Cited by 303 · see citing works
Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo
van Hinsbergh, V. W. M., Kooistra, T., van den Berg, E., Princen, H., Fiers, W., & Emeis, J. J. (1988) · Blood · doi:10.1182/blood.v72.5.1467.bloodjournal7251467 · Cited by 292 · see citing works
Current overview of statin-induced myopathy
Rosenson, R. S. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.10.033 · Cited by 287 · see citing works
Plasma Adiponectin and Leptin Levels, Body Composition, and Glucose Utilization in Adult Women With Wide Ranges of Age and Obesity
Ryan, A. S., Berman, D. M., Nicklas, B. J., Sinha, M., Gingerich, R. L., Meneilly, G. S., Egan, J. M., & Elahi, D. (2003) · Diabetes Care · doi:10.2337/diacare.26.8.2383 · Cited by 279 · see citing works
Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice
Ventre, J. R., Doebber, T. W., Wu, M. S., MacNaul, K. L., Stevens, K. A., Pasparakis, M., Kollias, G. A., & Moller, D. E. (1997) · Diabetes · doi:10.2337/diab.46.9.1526 · Cited by 275 · see citing works
Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives
Ogihara, T., Rakugi, H., IKEGAMI, H., Mikami, H., & Masuo, K. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(95)96214-5 · Cited by 274 · see citing works
17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism.
Pottratz, S. T., Bellido, T., Mocharla, H., Crabb, D. W., & Manolagas, S. C. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117100 · Cited by 269 · see citing works
Insulin Inhibits the Pro-Inflammatory Transcription Factor Early Growth Response Gene-1 (Egr)-1 Expression in Mononuclear Cells (MNC) and Reduces Plasma Tissue Factor (TF) and Plasminogen Activator Inhibitor-1 (PAI-1) Concentrations
Aljada, A., Ghanim, H., Mohanty, P., Kapur, N., & Dandona, P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8462 · Cited by 267 · see citing works
The Adipocyte and Hemostatic Balance in Obesity
Loskutoff, D. J., & Samad, F. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.1.1 · Cited by 265 · see citing works
Localization and production of plasminogen activator inhibitor-1 in human healthy and atherosclerotic arteries.
Lupu, F., Bergonzelli, G. E., Heim, D. A., Cousin, E., Genton, C., Bachmann, F., & Kruithof, E. K. O. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.7.1090 · Cited by 257 · see citing works
Effects of rosiglitazone alone and in combination with atorvastatin on the metabolic abnormalities in type 2 diabetes mellitus
Freed, M. I., Ratner, R. E., Marcovina, S. M., Kreider, M. S., Biswas, N., Cohen, B. R., & Brunzell, J. D. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02659-0 · Cited by 238 · see citing works
Blood pressure lowering by pioglitazone. Evidence for a direct vascular effect.
Buchanan, T. A., Meehan, W. P., Jeng, Y. Y., Yang, D. T., Chan, T. M., Nadler, J. L., Scott, S., Rude, R. K., & Hsueh, W. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118041 · Cited by 237 · see citing works
Insulin resistance, hypertension and microalbuminuria in patients with Type 2 (non-insulin-dependent) diabetes mellitus
Groop, L., Ekstrand, A., Forsblom, C. M., Wid�n, E., Groop, P., Teppo, A.-M., & Eriksson, J. G. (1993) · Diabetologia · doi:10.1007/bf00404074 · Cited by 235 · see citing works
Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo
van Hinsbergh, V. W. M., Kooistra, T., van den Berg, E., Princen, H. M. G., Fiers, W., & Emeis, J. J. (1988) · Blood · doi:10.1182/blood.v72.5.1467.1467 · Cited by 235 · see citing works
The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state
Tamakoshi, K., Yatsuya, H., Kondo, T., Hori, Y., Ishikawa, M., Zhang, H., Murata, C., Otsuka, R., Zhu, S., & Toyoshima, H. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802260 · Cited by 233 · see citing works
Postprandial lipemia, fenofibrate and coronary artery disease
Simpson, H., Williamson, C., Olivecrona, T., Pringle, S., MacLean, J. A., Lorimer, A. R., Bonnefous, F., Bogaievsky, Y., Packard, C. J., & Shepherd, J. (1990) · Atherosclerosis · doi:10.1016/0021-9150(90)90111-u · Cited by 229 · see citing works
Adipose tissue secretion of plasminogen activator inhibitor-1 in non-obese and obese individuals
Eriksson, P. O., Reynisdottir, S., Lönnqvist, F., Stemme, V., Hamsten, A., & Arner, P. (1998) · Diabetologia · doi:10.1007/s001250050868 · Cited by 227 · see citing works
Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1
Samad, F., Uysal, K. T., Wiesbrock, S. M., Pandey, M., Hotamisligil, G. S., & Loskutoff, D. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6902 · Cited by 226 · see citing works
Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines
Papanicolaou, D. A., Petrides, J. S., Tsigos, C., Bina, S., Kalogeras, K. T., Wilder, R. L., Gold, P. W., Deuster, P. A., & Chrousos, G. P. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.3.e601 · Cited by 225 · see citing works
Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients
Koh, K. K., Ahn, J. Y., Han, S. H., Kim, D. S., Jin, D., Kim, H. S., Shin, M., Ahn, T. H., Choi, I. S., & Shin, E. K. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00846-5 · Cited by 225 · see citing works
The cardiovascular risk factor plasminogen activator inhibitor type 1 is related to insulin resistance
van Loon, B. J. P., Kluft, C., Radder, J. K., Blankenstein, M. A., & Meinders, A. E. (1993) · Metabolism · doi:10.1016/0026-0495(93)90005-9 · Cited by 225 · see citing works
Evidence for increased levels of plasminogen activator inhibitor and tissue plasminogen activator in plasma of patients with angiographically verified coronary artery disease
OOLOFESSON, B. O., Dahlén, G., & Nilsson, T. (1989) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a059384 · Cited by 225 · see citing works
Impact of weight loss on plasminogen activator inhibitor (PAI-1), factor VII, and other hemostatic factors in moderately overweight adults.
Folsom, A. R., Qamhieh, H. T., Wing, R. R., Jeffery, R. W., Stinson, V., Kuller, L. H., & Wu, K. K. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.2.162 · Cited by 224 · see citing works
The metabolic syndrome, diabetes, and subclinicalatherosclerosis assessed by coronary calcium
Wong, N. D., Sciammarella, M. G., Polk, D. M., Gallagher, A. M., Miranda-Peats, L., Whitcomb, B. W., Hachamovitch, R., Friedman, J. D., Hayes, S. W., & Berman, D. S. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00193-1 · Cited by 220 · see citing works
Suppression of Nuclear Factor-κB and Stimulation of Inhibitor κB by Troglitazone: Evidence for an Anti-inflammatory Effect and a Potential Antiatherosclerotic Effect in the Obese
Ghanim, H., Garg, R., Aljada, A., Mohanty, P., Kumbkarni, Y., Assian, E., Hamouda, W., & Dandona, P. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7309 · Cited by 218 · see citing works
Relationships between plasma insulin triglyceride, body mass index, and plasminogen activator inhibitor 1.
Juhan-Vague, I., Vague, P., Alessi, M., Badier, C., Valadier, J., Aillaud, M.-F., & Atlan, C. (1987) · PubMed · Cited by 218 · see citing works
C-reactive protein is independently associated with total body fat, central fat, and insulin resistance in adult women
Pannacciulli, N., Cantatore, F. P., Minenna, A., Bellacicco, M., GIORGINO, R., & Pergola, G. D. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801719 · Cited by 209 · see citing works
Adiponectin, an Adipocyte-Derived Protein, Predicts Future Insulin Resistance: Two-Year Follow-Up Study in Japanese Population
Yamamoto, Y., Hirose, H., Saito, I., Nishikai, K., & Saruta, T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031163 · Cited by 208 · see citing works
Plasma plasminogen activator inhibitor-1 in angina pectoris. Influence of plasma insulin and acute-phase response.
Juhan-Vague, I., Alessi, M., Joly, P., Thirion, X., Vague, P., Declerck, P. J., Serradimigni, A., & Collen, D. (1989) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.9.3.362 · Cited by 201 · see citing works
Immune-neuro-endocrine interactions: facts and hypotheses
Besedovsky, H. O. (1996) · Endocrine Reviews · doi:10.1210/er.17.1.64 · Cited by 194 · see citing works
Markers of chronic inflammation and obesity: a prospective study on the reversibility of this association in middle-aged women undergoing weight loss by surgical intervention
Laimer, M. W., Ebenbichler, C. F., Kaser, S., Sandhofer, A., Weiß, H., Nehoda, H., Aigner, F., & Patsch, J. R. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801970 · Cited by 191 · see citing works
Plasminogen activator inhibitor activity and other fibrinolytic variables in patients with coronary artery disease.
Aznar, J., Estellés, A., Tormo, G. S., Sapena, P., Tormo, V., Blanch, S., & España, F. (1988) · Heart · doi:10.1136/hrt.59.5.535 · Cited by 188 · see citing works
Effects of statins on nonlipid serum markers associated with cardiovascular disease: a systematic review.
Balk, E. M., Lau, J., Goudas, L. C., Jordan, H. S., Kupelnick, B., Kim, L. U., & Karas, R. H. (2003) · PubMed · doi:10.7326/0003-4819-139-8-200310210-00011 · Cited by 185 · see citing works
Fibrates in 2003: therapeutic action in atherogenic dyslipidaemia and future perspectives
Chapman, M. J. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00156-4 · Cited by 181 · see citing works
C-reactive protein and interleukin-6 in vascular disease
Rattazzi, M., Puato, M., Faggin, E., Bertipaglia, B., Zambon, A., & Pauletto, P. (2003) · Journal of Hypertension · doi:10.1097/00004872-200310000-00002 · Cited by 179 · see citing works
Insulin-induced vasodilatation and endothelial function in obesity/insulin resistance. Effects of troglitazone
Tack, C. J. J., Ong, M. K. E., Lutterman, J. A., & Smits, P. (1998) · Diabetologia · doi:10.1007/s001250050948 · Cited by 177 · see citing works
The Metabolic Syndrome: Peroxisome Proliferator-Activated Receptor γ and Its Therapeutic Modulation
Gurnell, M., Savage, D. B., Chatterjee, K., & O’Rahilly, S. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030435 · Cited by 177 · see citing works
Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia
Musiał, J., Undas, A., Gajewski, P., Jankowski, M., Sydor, W., & Szczeklik, A. (2001) · International Journal of Cardiology · doi:10.1016/s0167-5273(00)00439-3 · Cited by 175 · see citing works
Irbesartan, an angiotensin type 1 receptor inhibitor, regulates markers of inflammation in patients with premature atherosclerosis
Navalkar, S., Parthasarathy, S., Santanam, N., & Khan, B. V. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)01138-4 · Cited by 171 · see citing works
Hormone Replacement Therapy and Interrelation between Serum Interleukin-6 and Body Mass Index in Postmenopausal Women: A Population-Based Study
Straub, R. H., Hense, H. W., Andus, T., Schölmerich, J., Riegger, G. A. J., & Schunkert, H. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6355 · Cited by 170 · see citing works
Insulin Inhibits the Expression of Intercellular Adhesion Molecule-1 by Human Aortic Endothelial Cells through Stimulation of Nitric Oxide1
Aljada, A., Saadeh, R., Assian, E., Ghanim, H., & Dandona, P. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6677 · Cited by 166 · see citing works
Interleukin-6: The Endocrine Cytokine
Papanicolaou, D. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.3.6582 · Cited by 159 · see citing works
Comparison of Intensive and Moderate Lipid Lowering With Statins After Acute Coronary Symptoms
Cannon, C. P., D, E. B. M., McCabe, C. H., Rader, D. J., Rouleau, J. L., Belder, R., Joyal, S. V., Hill, K. A., Pfeffer, M. A., & Skene, A. M. (2004) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200407000-00019 · Cited by 159 · see citing works
Early vascular benefits of statin therapy
Tsiara, S., Elisaf, M., & Mikhailidis, D. P. (2003) · Current Medical Research and Opinion · doi:10.1185/030079903125002225 · Cited by 157 · see citing works
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ∞ AND METABOLIC DISEASE
Willson, T. M., Lambert, M. H., & Kliewer, S. A. (2001) · Cited by 154 · see citing works
Production of plasminogen activator inhibitor 1 by human adipose tissue: possible link between visceral fat accumulation and vascular disease
Alessi, M., Peiretti, F., Morange, P., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.5.860 · Cited by 154 · see citing works
Body Mass Index, but Not Physical Activity, Is Associated with C-Reactive Protein
RAWSON, E. S., FREEDSON, P. S., OSGANIAN, S. K., MATTHEWS, C. E., REED, G., & OCKENE, I. S. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000074565.79230.ab · Cited by 144 · see citing works
Angiotensin II Type 1 Receptor Antagonism Improves Hypercholesterolemia-Associated Endothelial Dysfunction
Waßmann, S., Hilgers, S., Laufs, U., Böhm, M., & Nickenig, G. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000022847.38083.b6 · Cited by 141 · see citing works
Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest
Siscovick, D. S. (1995) · JAMA · doi:10.1001/jama.274.17.1363 · Cited by 140 · see citing works
Fat distribution and plasminogen activator inhibitor activity in nondiabetic obese women
Vague, P., Juhan-Vague, I., Chabert, V., Alessi, M., & Atlan, C. (1989) · Metabolism · doi:10.1016/0026-0495(89)90241-2 · Cited by 126 · see citing works
Rationale and design of a secondary prevention trial of lowering normal plasma cholesterol levels after acute myocardial infarction: The cholesterol and recurrent events trial (CARE)
Sacks, F. M., Pfeffer, M. A., Moyé, L. A., Brown, L. E., Hamm, P., Cole, T. G., HAWKINS, C. M., D, E. B. M., & The CARE Investigators (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90276-q · Cited by 125 · see citing works
Effect of Troglitazone on Fibrinolysis and Activated Coagulation in Patients With Non–Insulin-Dependent Diabetes Mellitus
Fonseca, V. A., Reynolds, T., Hemphill, D., Randolph, C., Wall, J., Valiquett, T. R., Graveline, J. F., & Fink, L. M. (1998) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(97)00109-8 · Cited by 123 · see citing works
Relationship between plasma plasminogen activator inhibitor-1 activity and VLDL triglyceride concentration, insulin levels and insulin sensitivity: studies in randomly selected normo- and hypertriglyceridaemic men
Asplund-Carlson, A., Hamsten, A., Wiman, B., & Carlson, L. A. (1993) · Diabetologia · doi:10.1007/bf00400356 · Cited by 120 · see citing works
Nonsteroidal Anti-Inflammatory drugs and cardiovascular risk
Howard, P. A., & Delafontaine, P. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.09.043 · Cited by 118 · see citing works
Inflammatory markers and coronary heart disease
Rifai, N., & Ridker, P. M. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200208000-00005 · Cited by 115 · see citing works
Impaired fibrinolysis in coronary artery disease
Francis, R. B., Kawanishi, D. T., Baruch, T., Mahrer, P. R., Rahimtoola, S. H., & Feinstein, D. I. (1988) · American Heart Journal · doi:10.1016/0002-8703(88)90878-2 · Cited by 113 · see citing works
Elevated levels of the rapid inhibitor of plasminogen activator (t-PAI) in acute myocardial infarction
Almér, L., & Öhlin, H. (1987) · Thrombosis Research · doi:10.1016/0049-3848(87)90147-2 · Cited by 111 · see citing works
HMG CoA reductase inhibitors affect the fibrinolytic system of human vascular cells in vitro: a comparative study using different statins
Wiesbauer, F., Kaun, C., Zorn, G., Maurer, G., Huber, K., & Wojta, J. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704454 · Cited by 111 · see citing works

Flagged first, then by citations

Sorted by citations

The metabolic syndrome
Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,283 · see citing works
Self-citation
The metabolic syndrome
Eckel, R. H., Grundy, S. M., & Zimmet, P. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66378-7 · Cited by 5,565 · see citing works
Self-citation
The Metabolic Syndrome
Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162 · see citing works
Self-citation
The Metabolic Syndrome
Grundy, S. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-5839-6_1 · Cited by 1,225 · see citing works
The vagus nerve and the inflammatory reflex – linking immunity and metabolism
Pavlov, V. A., & Tracey, K. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.189 · Cited by 1,040 · see citing works
Advanced Glycation End Products and Diabetes Mellitus: Mechanisms and Perspectives
Khalid, M., Petroianu, G. A., & Adem, A. (2022) · Biomolecules · doi:10.3390/biom12040542 · Cited by 931 · see citing works
The Effects of Diet on Inflammation
Giugliano, D., Ceriello, A., & Esposito, K. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.03.052 · Cited by 842 · see citing works
Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover
Unger, R. H., & Cherrington, A. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60016 · Cited by 670 · see citing works
Treatment of Obesity
Wolfe, B. M., Kvach, E., & Eckel, R. H. (2016) · Circulation Research · doi:10.1161/circresaha.116.307591 · Cited by 659 · see citing works
Self-citation
Non alcoholic fatty liver disease and metabolic syndrome.
Paschos, P., & Paletas, K. (2009) · PubMed Central · Cited by 539 · see citing works
Anxiety disorders and inflammation in a large adult cohort
Vogelzangs, N., Beekman, A. T. F., de Jonge, P., & Penninx, B. W. J. H. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.27 · Cited by 458 · see citing works
Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity
Unger, R. H., & Scherer, P. E. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.01.009 · Cited by 436 · see citing works
The Role of Triglycerides in Atherosclerosis
Talayero, B., & Sacks, F. M. (2011) · Current Cardiology Reports · doi:10.1007/s11886-011-0220-3 · Cited by 356 · see citing works
The association between loneliness, social isolation and inflammation: A systematic review and meta-analysis
Smith, K. J., Gavey, S., Riddell, N. E., Kontari, P., & Victor, C. R. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.002 · Cited by 341 · see citing works
Association of depressive disorders, depression characteristics and antidepressant medication with inflammation
Vogelzangs, N., Duivis, H. E., Beekman, A. T. F., Kluft, C., Neuteboom, J., Hoogendijk, W., Smit, J. H., de Jonge, P., & Penninx, B. W. J. H. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.8 · Cited by 323 · see citing works
“Several studies have confirmed an association between CRP, IL-6 and TNF-a with the metabolic syndrome and visceral fat depots release cytokines.(30) The metabolic syndrome and in particular visceral fat have been bidirectionally associated with depression in late life,(31,32) specifically in men.”
Background
Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders
Mattson, M. P. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.07.003 · Cited by 303 · see citing works
Aging and dyslipidemia: A review of potential mechanisms
Liu, H., & Li, J. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.12.001 · Cited by 275 · see citing works
Eating ourselves to death (and despair): The contribution of adiposity and inflammation to depression
Shelton, R. C., & Miller, A. H. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.004 · Cited by 257 · see citing works
Activation and modulation of the AGEs-RAGE axis: Implications for inflammatory pathologies and therapeutic interventions – A review
Zhou, M., Zhang, Y., Shi, L., Li, L., Zhang, D., Gong, Z., & Wu, Q. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107282 · Cited by 256 · see citing works
Circulating Adiponectin Levels Are Associated with Better Glycemic Control, More Favorable Lipid Profile, and Reduced Inflammation in Women with Type 2 Diabetes
Mantzoros, C. S., Li, T., Manson, J. E., Meigs, J. B., & Hu, F. B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0372 · Cited by 224 · see citing works
Metabolic syndrome, age‐associated neuroendocrine disorders, and dysregulation of tryptophan—kynurenine metabolism
Oxenkrug, G. F. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05356.x · Cited by 221 · see citing works
Prevention of type 2 diabetes in subjects with prediabetes and metabolic syndrome treated with phentermine and topiramate extended release
Garvey, W. T., Ryan, D. H., Henry, R., Bohannon, N. J. V., Toplak, H., Schwiers, M., Troupin, B., & Day, W. W. (2014) · Diabetes Care · doi:10.2337/dc13-1518 · Cited by 215 · see citing works
Naringin ameliorates metabolic syndrome by activating AMP-activated protein kinase in mice fed a high-fat diet
Pu, P., Gao, D.-M., Salim, M., Chen, J., Zhang, J., Zhou, X., Nai-jing, Z., Xie, J., & Jiang, H. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.11.026 · Cited by 203 · see citing works
Metabolically healthy obesity from childhood to adulthood — Does weight status alone matter?
Blüher, S., & Schwarz, P. E. H. (2014) · Metabolism · doi:10.1016/j.metabol.2014.06.009 · Cited by 184 · see citing works
Serum Progranulin Concentrations May Be Associated With Macrophage Infiltration Into Omental Adipose Tissue
Youn, B., Bang, S. I., Klöting, N., Park, J. W., Lee, N., Oh, J.-E., Pi, K., Lee, T. H., Ruschke, K., Faßhauer, M., et al. (2008) · Diabetes · doi:10.2337/db08-1147 · Cited by 169 · see citing works
Age Related Shift in Visceral Fat.
Hunter, G. R., Gower, B. A., & Kane, B. (2010) · PubMed · Cited by 160 · see citing works
Non-Digestible Food Ingredients, Colonic Microbiota and the Impact on Gut Health and Immunity: A Role for Metabolomics
Jacobs, D. M., Gaudier, E. A., van Duynhoven, J., & Vaughan, E. E. (2009) · Current Drug Metabolism · doi:10.2174/138920009787048383 · Cited by 162 · see citing works
Nutrient intakes and the common mental disorders in women
Jacka, F. N., Maes, M., Pasco, J. A., Williams, L. J., & Berk, M. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.02.018 · Cited by 149 · see citing works
Does Metabolically Healthy Obesity Exist?
Muñoz‐Garach, A., Cornejo-Pareja, I. M., & Tinahones, F. J. (2016) · Nutrients · doi:10.3390/nu8060320 · Cited by 145 · see citing works
Inflammation in depression: is adiposity a cause?
Shelton, R. C., & Miller, A. H. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.1/rshelton · Cited by 143 · see citing works
Inflammatory and Metabolic Dysregulation and the 2-Year Course of Depressive Disorders in Antidepressant Users
Vogelzangs, N., Beekman, A. T., van Reedt Dortland, A. K., Schoevers, R. A., Giltay, E. J., de Jonge, P., & Penninx, B. W. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.9 · Cited by 133 · see citing works
Effects of a 1‐year exercise and lifestyle intervention on irisin, adipokines, and inflammatory markers in obese children
Blüher, S., Panagiotou, G., Petroff, D., Markert, J., Wagner, A., Klemm, T., Filippaios, A., Keller, A., & Mantzoros, C. S. (2014) · Obesity · doi:10.1002/oby.20739 · Cited by 130 · see citing works
Proinflammatory Cytokine and Chemokine Gene Expression Profiles in Subcutaneous and Visceral Adipose Tissue Depots of Insulin-Resistant and Insulin-Sensitive Light Breed Horses
Burns, T. A., Geor, R. J., Mudge, M. C., McCutcheon, L. J., Hinchcliff, K. W., & Belknap, J. K. (2010) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2010.0551.x · Cited by 128 · see citing works
Changes in cardiovascular biomarkers in HIV-infected patients switching from ritonavir-boosted protease inhibitors to raltegravir
Martínez, E., d’Albuquerque, P. M., Llibre, J. M., Gutiérrez, F., Podzamczer, D., Antela, A., Berenguer, J., Domingo, P., Moreno, X. C., Pérez, I., et al. (2012) · AIDS · doi:10.1097/qad.0b013e328359f29c · Cited by 125 · see citing works
Epidemiology of Cardiovascular Disease in Type 2 Diabetes: The Indian Scenario
Mohan, V., Venkatraman, J. V., & Pradeepa, R. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400121 · Cited by 125 · see citing works
Baicalein, a natural product, selectively activating AMPKα2 and ameliorates metabolic disorder in diet-induced mice
Pu, P., Wang, X.-A., Salim, M., Zhu, L., Wang, L., Chen, K.-J., Xiao, J., Deng, W., Shi, H., Jiang, H., et al. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.002 · Cited by 122 · see citing works
Galantamine Alleviates Inflammation and Other Obesity-Associated Complications in High-Fat Diet-Fed Mice
Satapathy, S. K., Ochani, M., Dancho, M. E., Hudson, L., Rosas‐Ballina, M., Valdés‐Ferrer, S. I., Olofsson, P. S., Harris, Y., Roth, J., Chavan, S. S., et al. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00083 · Cited by 119 · see citing works
The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk. A pilot double blind randomized placebo controlled trial
Atkin, M., Laight, D. W., & Cummings, M. H. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.01.003 · Cited by 112 · see citing works
The Role of Lipids and Lipoproteins in Atherosclerosis
Linton, M. F., Yancey, P. G., Davies, S. S., Jerome, W. G., Linton, E. F., Song, W., Doran, A. C., & Vickers, K. C. (2015) · Europe PMC (PubMed Central) · Cited by 108 · see citing works
The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome
Thoenes, M., Oguchi, A., Nagamia, S. H., Vaccari, C. S., Hammoud, R., Umpierrez, G. E., & Khan, B. V. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01597.x · Cited by 109 · see citing works
Systemic Biomarkers of Neutrophilic Inflammation, Tissue Injury and Repair in COPD Patients with Differing Levels of Disease Severity
Cockayne, D. A., Cheng, D. T., Waschki, B., Sridhar, S., Ravindran, P., Hilton, H., Kourteva, G., Bitter, H., Pillai, S. G., Visvanathan, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038629 · Cited by 101 · see citing works
Title: Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment
Fuertes-Martín, R., Correig, X., Vallvé, J.-C., & Amigó, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020354 · Cited by 98 · see citing works
The metabolic syndrome, diabetes and lung dysfunction
Tiengo, A., Fadini, G. P., & Avogaro, A. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2008.08.001 · Cited by 93 · see citing works
Childhood Obesity and Cancer Risk in Adulthood
Weihe, P., Spielmann, J., Kielstein, H., Klusmann, J., & Blüher, S. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00387-w · Cited by 96 · see citing works
Plasma Progranulin Concentrations Are Increased in Patients with Type 2 Diabetes and Obesity and Correlated with Insulin Resistance
Qu, H., Deng, H., & Hu, Z.-P. (2013) · Mediators of Inflammation · doi:10.1155/2013/360190 · Cited by 93 · see citing works
Cytokine and growth factor profiling in patients with the metabolic syndrome
Mirhafez, S. R., Pasdar, A., Avan, A., Esmaily, H., Moezzi, A., Mohebati, M., Meshkat, Z., Mehrad‐Majd, H., Eslami, S., Rahimi, H. R., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515001038 · Cited by 90 · see citing works
Activation of PPARβ/δ Causes a Psoriasis-Like Skin Disease In Vivo
Romanowska, M., Reilly, L., Palmer, C. N. A., Gustafsson, M. C. U., & Foerster, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009701 · Cited by 86 · see citing works
Exercise-induced lowering of fetuin-A may increase hepatic insulin sensitivity
Malin, S. K., del Rincon, J. P., Huang, H., & Kirwan, J. P. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000338 · Cited by 85 · see citing works
Effects of Caloric Restriction on Cardiovascular Aging in Non-human Primates and Humans
Cruzen, C., & Colman, R. J. (2009) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2009.07.001 · Cited by 82 · see citing works
Autophagy in metabolic syndrome: breaking the wheel by targeting the renin–angiotensin system
Menikdiwela, K. R., Ramalingam, L., Rasha, F. A., Wang, S. F., Dufour, J. M., Kalupahana, N. S., Sunahara, K. K. S., Martins, J. O., & Moustaïd‐Moussa, N. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2275-9 · Cited by 81 · see citing works
Obesity, metabolic syndrome and diabetic retinopathy: Beyond hyperglycemia
Mbata, O., El‐Magd, N. F. A., & El‐Remessy, A. B. (2017) · World Journal of Diabetes · doi:10.4239/wjd.v8.i7.317 · Cited by 72 · see citing works
Metabolic biomarkers and gallstone disease – a population-based study
Shabanzadeh, D. M., Skaaby, T., Sørensen, L. T., Eugen‐Olsen, J., & Jørgensen, T. (2017) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2017.1365166 · Cited by 74 · see citing works
Effects of Maillard reaction and its product AGEs on aging and age-related diseases
Peng, H., Gao, Y., Zeng, C., Hua, R., Guo, Y.-N., Wang, Y., & Wang, Z. (2023) · Food Science and Human Wellness · doi:10.26599/fshw.2022.9250094 · Cited by 69 · see citing works
Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle-aged and older Chinese
Qi, Q., Wang, J., Li, H., Yu, Z., Ye, X., Hu, F. B., Franco, O. H., Pan, A., Liu, Y., & Xu, L. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0427 · Cited by 68 · see citing works
Mechanisms of the components of the metabolic syndrome that predispose to diabetes and atherosclerotic CVD
Eckel, R. H. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005320 · Cited by 68 · see citing works
Self-citation
Insulin Sensitivity in African‐American and White Women: Association With Inflammation
Hyatt, T. C., Phadke, R. P., Hunter, G. R., Bush, N. C., Muñoz, A. J., & Gower, B. A. (2009) · Obesity · doi:10.1038/oby.2008.549 · Cited by 67 · see citing works
Açaí ( Euterpe oleracea Mart.) beverage consumption improves biomarkers for inflammation but not glucose- or lipid-metabolism in individuals with metabolic syndrome in a randomized, double-blinded, placebo-controlled clinical trial
Kim, H., Simbo, S. Y., Fang, C., McAlister, L., Roque, A., Banerjee, N., Talcott, S. T., Zhao, H., Kreider, R. B., & Mertens‐Talcott, S. U. (2018) · Food & Function · doi:10.1039/c8fo00595h · Cited by 67 · see citing works
The Associations between Serum Zinc Levels and Metabolic Syndrome in the Korean Population: Findings from the 2010 Korean National Health and Nutrition Examination Survey
Seo, J., Song, S.-W., Han, K., Lee, K.-J., & Kim, H.-N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105990 · Cited by 66 · see citing works
Protective effects of L-arabinose in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats
Hao, L., Lu, X., Sun, M., Li, K., Shen, L., & Wu, T. (2015) · Food & Nutrition Research · doi:10.3402/fnr.v59.28886 · Cited by 62 · see citing works
Plasma concentrations of TNF‐α and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease
Safranow, K., Dziedziejko, V., Rzeuski, R., Czyżycka, E., Wojtarowicz, A., Bińczak‐Kuleta, A., Jakubowska, K., Olszewska, M. J., Ciechanowicz, A., Kornacewicz‐Jach, Z., et al. (2009) · Tissue Antigens · doi:10.1111/j.1399-0039.2009.01332.x · Cited by 61 · see citing works
The pro-inflammatory profile of depressed patients is (partly) related to obesity
Shelton, R. C., Falola, M. I., Li, L., Zajecka, J., D, M. F. M., & Papakostas, G. I. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.09.001 · Cited by 57 · see citing works
Inflammatory Biomarkers in 70 Depressed Inpatients With and Without the Metabolic Syndrome
Zeugmann, S., Quante, A., Heuser, I., Schwarzer, R., & Anghelescu, I. G. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04767blu · Cited by 56 · see citing works
Systemic inflammation and metabolic syndrome in stable COPD patients
Akpınar, E. E., Akpınar, S., Ertek, S., Gülensoy, E. S., & Gülhan, M. (2012) · Tuberkuloz ve Toraks · doi:10.5578/tt.4018 · Cited by 57 · see citing works
Elevated body mass index correlates with higher seminal plasma interleukin 8 levels and ultrasonographic abnormalities of the prostate in men attending an andrology clinic for infertility.
Lotti, F., Corona, G., Colpi, G. M., FILIMBERTI, E., Innocenti, S. D., Mancini, M., Baldi, E., Noci, I., Forti, G., Adorini, L., et al. (2011) · PubMed · doi:10.3275/7855 · Cited by 57 · see citing works
Metabolic Syndrome is associated with increased risk of acute exacerbation of COPD: a preliminary study
Küpeli̇, E., Ulubay, G., Ulaşlı, S. S., Sahin, T., Ozen, Z. E., & Gürsoy, A. (2010) · Endocrine · doi:10.1007/s12020-010-9351-3 · Cited by 56 · see citing works
Tumor necrosis factor‐α‐induced inflammatory responses in cattle
Kushibiki, S. (2011) · Animal Science Journal · doi:10.1111/j.1740-0929.2011.00931.x · Cited by 52 · see citing works
The consequences of HIV infection and antiretroviral therapy use for cardiovascular disease risk: shifting paradigms
Baker, J. V., Henry, W. K., & Neaton, J. D. (2009) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e328329c62f · Cited by 52 · see citing works
Links between Childhood Obesity, High-Fat Diet, and Central Precocious Puberty
Calcaterra, V., Magenes, V. C., Hruby, C., Siccardo, F., Mari, A., Cordaro, E., Fabiano, V., & Zuccotti, G. (2023) · Children · doi:10.3390/children10020241 · Cited by 55 · see citing works
The evolving obesity challenge: targeting the vagus nerve and the inflammatory reflex in the response
Pavlov, V. A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107794 · Cited by 49 · see citing works
Dairy Consumption Lowers Systemic Inflammation and Liver Enzymes in Typically Low-Dairy Consumers with Clinical Characteristics of Metabolic Syndrome
Dugan, C. E., Aguilar, D., Park, Y., Lee, J., & Fernández, M. L. (2015) · Journal of the American College of Nutrition · doi:10.1080/07315724.2015.1022637 · Cited by 50 · see citing works
The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the Metabolic Syndrome in a Randomized Trial
Sangaleti, C. T., Katayama, K. Y., Angelis, K. D., de Moraes, T. L., de Araújo, A. A., Lopes, H. F., Camacho, C. P., Bortolotto, L. A., Michelini, L. C., Irigoyen, M. C., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.613979 · Cited by 50 · see citing works
Management of the metabolic syndrome.
Hafidh, S., Senkottaiyan, N., Alpert, M., & Villarreal, D. (2005) · American Journal of the Medical Sciences · doi:10.1097/00000441-200512000-00013 · Cited by 8 · see citing works
Testosterone Regulates Tight Junction Proteins and Influences Prostatic Autoimmune Responses
Meng, J., Mostaghel, E. A., Vakar‐Lopez, F., Montgomery, B., True, L., & Nelson, P. S. (2011) · Hormones and Cancer · doi:10.1007/s12672-010-0063-1 · Cited by 48 · see citing works
Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study
Povel, C. M., Boer, J. M. A., Onland‐Moret, N. C., Dollé, M. E. T., Feskens, E. J. M., & van der Schouw, Y. T. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-133 · Cited by 49 · see citing works
A Larger Body Mass Index is Associated with Increased Atherogenic Dyslipidemia, Insulin Resistance, and Low-Grade Inflammation in Individuals with Metabolic Syndrome
Ebron, K., Andersen, C. J., Aguilar, D., Blesso, C. N., Barona, J., Dugan, C. E., Jones, J. L., Al‐Sarraj, T., & Fernández, M. L. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0053 · Cited by 48 · see citing works
Metabolic syndrome in psychiatry: advances in understanding and management
Ho, C. S. H., Zhang, M. W., Mak, A., & Ho, R. (2014) · Advances in Psychiatric Treatment · doi:10.1192/apt.bp.113.011619 · Cited by 47 · see citing works
Exploratory lipidomics in patients with nascent Metabolic Syndrome
Ramakrishanan, N., Denna, T., Devaraj, S., ADAMS-HUET, B. A., & Jialal, I. (2018) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2018.05.014 · Cited by 47 · see citing works
Dietary Advanced Glycation End Products: Their Role in the Insulin Resistance of Aging
Portero‐Otín, M., de la Maza, M. P., & Uribarri, J. (2023) · Cells · doi:10.3390/cells12131684 · Cited by 45 · see citing works
Aging per se Increases the Susceptibility to Free Fatty Acid-Induced Insulin Resistance
Einstein, F. H., Huffman, D. M., Fishman, S., Jerschow, E., Heo, H. J., Atzmon, G., Schechter, C. B., Barzilai, N., & Muzumdar, R. H. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq078 · Cited by 46 · see citing works
Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation
Xie, H., Yepuri, N., Meng, Q., Dhawan, R., Leech, C. A., Chepurny, O., Holz, G. G., & Cooney, R. (2020) · Reviews in Endocrine & Metabolic Disorders · doi:10.1007/s11154-020-09584-3 · Cited by 37 · see citing works
Poly ADP-ribose polymerase-1 and health
Kirkland, J. B. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.009280 · Cited by 40 · see citing works
Metabolic syndrome is associated with an increased risk of psoriasis: A nationwide population-based study
Kim, H.-N., Han, K., Park, Y. G., & Lee, J. H. (2019) · Metabolism · doi:10.1016/j.metabol.2019.07.001 · Cited by 38 · see citing works
Ferroptosis and metabolic syndrome and complications: association, mechanism, and translational applications
Zhou, D., Lu, P., Mo, X., Yang, B., Chen, T., Yao, Y., Xiong, T., Lin, Y., & Yang, X. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1248934 · Cited by 36 · see citing works
Advances and challenges in pursuing biomarkers for obstructive sleep apnea: Implications for the cardiovascular risk
Lebkuchen, A., Freitas, L. S., Cardozo, K. H. M., & Drager, L. F. (2020) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2020.04.003 · Cited by 36 · see citing works
Ezetimibe added to atorvastatin compared with doubling the atorvastatin dose in patients at high risk for coronary heart disease with diabetes mellitus, metabolic syndrome or neither
Conard, S. E., Bays, H. E., Leiter, L. A., Bird, S., Lin, J., Hanson, M. E., Shah, A. K., & Tershakovec, A. M. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01152.x · Cited by 35 · see citing works
Mechanisms linking endoplasmic reticulum (ER) stress and microRNAs to adipose tissue dysfunction in obesity
Menikdiwela, K. R., Guimarães, J. P. T., Ramalingam, L., Kalupahana, N. S., Dufour, J. M., Washburn, R. L., & Moustaïd‐Moussa, N. (2021) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2021.1925219 · Cited by 35 · see citing works
Obesity and Dyslipidemia in Behaviorally HIV‐Infected Young Women: Adolescent Trials Network Study 021
Mulligan, K. M., Harris, D. R., Monte, D., Stoszek, S., Emmanuel, P. J., Hardin, D. S., Kapogiannis, B. G., Worrell, C. J., Meyer, W. A., Sleasman, J. W., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/648728 · Cited by 34 · see citing works
Metabolic syndrome and obesity in peritoneal dialysis
Lo, W. K. (2016) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2015.12.007 · Cited by 33 · see citing works
The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966
Sinikumpu, S., Huilaja, L., AUVINEN, J. P., Jokelainen, J. J., Puukka, K. S., Ruokonen, A., Timonen, M., & Tasanen, K. (2017) · Acta Dermato Venereologica · doi:10.2340/00015555-2795 · Cited by 33 · see citing works
Lactobacillus Brevis OPK-3 from Kimchi Prevents Obesity and Modulates the Expression of Adipogenic and Pro-Inflammatory Genes in Adipose Tissue of Diet-Induced Obese Mice
Park, J. E., Oh, S., & Cha, Y. (2020) · Nutrients · doi:10.3390/nu12030604 · Cited by 33 · see citing works
Influence of dietary patterns on the metabolically healthy obesity phenotype: A systematic review
Vilela, D. L. D. S., da Fonseca, P. G., Pinto, S. L., & Bressan, J. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.05.007 · Cited by 33 · see citing works
Late-life depression symptom profiles are differentially associated with immunometabolic functioning
Vogelzangs, N., Comijs, H. C., Oude Voshaar, R. C., Stek, M. L., & Penninx, B. W. J. H. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.05.004 · Cited by 32 · see citing works
Next-Generation (Glycomic) Biomarkers for Cardiometabolic Health: A Community-Based Study of Immunoglobulin G N -Glycans in a Chinese Han Population
Wang, H., Li, X., Wang, X., Liu, D., Zhang, X., Cao, W., Zheng, Y., Guo, Z., Li, D., Xing, W., et al. (2019) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2019.0099 · Cited by 30 · see citing works
Correlation between pre‐operative metabolic syndrome and persistent blood glucose elevation during cardiac surgery in non‐diabetic patients
Donatelli, F., Cavagna, P., Dedda, G. D., CATENACCI, A., Nicola, M. D., Lorini, F. L., Fumagalli, R., & Carli, F. (2008) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2008.01693.x · Cited by 29 · see citing works
Psychosocial Predictors of Metabolic Syndrome among Latino Groups in the Multi-Ethnic Study of Atherosclerosis (MESA)
Ortíz, M. S., Myers, H. F., Schetter, C. D., Rodríguez, C. J., & Seeman, T. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124517 · Cited by 29 · see citing works
A closer look at the role of urotensin II in the metabolic syndrome
Barrette, P.-O., & Schwertani, A. G. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00165 · Cited by 29 · see citing works
Association of non-alcoholic fatty liver disease with coronary artery calcification progression: a systematic review and meta-analysis
Koulaouzidis, G., Charisopoulou, D., Kukla, M., Marlicz, W. M., Rydzewska, G. M., Koulaouzidis, A., & Skonieczna‐Żydecka, K. (2021) · Gastroenterology Review · doi:10.5114/pg.2021.109063 · Cited by 29 · see citing works
An examination of the prevalence of metabolic syndrome in older adults in Ireland: Findings from The Irish Longitudinal Study on Ageing (TILDA)
McCarthy, K., Laird, E. J., O’Halloran, A. M., Fallon, P. G., O’Connor, D. M. A., Romero‐Ortuño, R., & Kenny, R. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0273948 · Cited by 29 · see citing works
Regulated renin release from 3T3-L1 adipocytes
Fowler, J. D., Johnson, N. D., Haroldson, T. A., Brintnall, J. A., Herrera, J. E., Katz, S. A., & Bernlohr, D. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00025.2009 · Cited by 29 · see citing works
Cardiovascular and metabolic risk in outpatients with schizoaffective disorder treated with antipsychotics: Results from the CLAMORS study
Bobes, J., Arango, C., Aranda, P., Carmena, R., García-García, M., Rejas, J., & on behalf of the CLAMORS Study Collaborative Group (2010) · European Psychiatry · doi:10.1016/j.eurpsy.2010.09.001 · Cited by 28 · see citing works

Authors: Sutherland, J. P., McKinley, B., & Eckel, R. H.
Affiliations: University of Colorado Health Sciences Center, Denver, Colorado.
ORCID: Eckel, Robert H.
Venue: Metabolic Syndrome and Related Disorders
Publisher: SAGE Publications
Published: 2004-06
Volume: 2
Issue: 2
Pages: 82-104
ISSN: 1540-4196 (ISSN-L)
1557-8518
DOI: 10.1089/met.2004.2.82
OpenAlex: W2028053287
Cited by: 243
References: 238
Citations by year: 2026: 4 · 2025: 12 · 2024: 11 · 2023: 12 · 2022: 8 · 2021: 11 · 2020: 15 · 2019: 10 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 15
FWCI: 2.68
Type: journal article
Language: en
Open access: closed
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Metabolic Syndrome and Related Disorders (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: metabolic syndrome, chronic inflammation, insulin resistance, coronary heart disease prevention, inflammatory markers, C-reactive protein, TNF-α, interleukin-6, fibrinogen, adiponectin, plasminogen activator inhibitor-1, obesity, cardiovascular risk factors, lifestyle intervention, pharmacotherapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Metabolic Syndrome and Inflammation

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks