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Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor.
Open accessAbstract
Human endothelial cells activated with IL-1 express a surface membrane-oriented procoagulant generating system characterized by increased tissue factor synthesis and decreased thrombomodulin activity. We now report that IL-1 also stimulates endothelial cell synthesis of plasminogen activator inhibitor. This array of IL-1-induced activities shifts the balance at the endothelial cell surface to a prothrombotic influence and may reflect an early response of the blood vessel wall to injury.
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Citations
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Wahaidi, V. Y., Kowolik, M. J., Eckert, G. J., & Galli, D. M. (2011) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01710.x · Cited by 32
Metadata
- Authors
- Nachman, R. L., Hajjar, K. A., Silverstein, R. L., & Dinarello, C. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1986-06-01
- Volume
- 163
- Issue
- 6
- Pages
- 1595-1600
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2042775328
- Cited by
- 316
- References
- 0
- FWCI
- 21.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor. https://app.cochat.ai/papers/10.1084/jem.163.6.1595
- The paper
- Nachman, R. L., Hajjar, K. A., Silverstein, R. L., & Dinarello, C. A. (1986). Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor. The Journal of experimental medicine. https://doi.org/10.1084/jem.163.6.1595
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
