The DOI matches its Crossref record.
Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.
Open accessAbstract
Exposure of mouse resident and thioglycollate-elicited peritoneal macrophages to IFN-gamma leads to a marked increase in the TNF-alpha (tumor necrosis factor/cachectin), IL-1 and u-PA (urokinase-type plasminogen activator) mRNA levels. Nuclear run-on experiments show that IFN-gamma acts by enhancing the transcription of these three genes. Transcription of these three genes is also rapidly and transiently induced by cycloheximide, an inhibitor of protein synthesis, indicating that they are under the control of short-lived repressors.
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Citations
Cited by
Kindler, V., Sappino, A.-P., Grau, G. E., Piguet, P.-F., & Vassalli, P. (1989) · Cell · doi:10.1016/0092-8674(89)90676-4 · Cited by 1,254
Self-citationShakhov, A. N., Collart, M. A., Vassalli, P., Nedospasov, S. A., & Jongeneel, C. V. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.1.35 · Cited by 819
Self-citationRock, C. S., & Lowry, S. F. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90146-d · Cited by 503
Han, J., Brown, T., & Beutler, B. (1990) · The Journal of experimental medicine · doi:10.1084/jem.171.2.465 · Cited by 477
Sherry, B., & Cerami, A. (1988) · The Journal of cell biology · doi:10.1083/jcb.107.4.1269 · Cited by 432
Metadata
- Authors
- Collart, M. A., Belin, D., Vassalli, J. D., de Kossodo, S., & Vassalli, P.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1986-12-01
- Volume
- 164
- Issue
- 6
- Pages
- 2113-2118
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2085374906
- Cited by
- 524
- References
- 0
- FWCI
- 17.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors. https://app.cochat.ai/papers/10.1084/jem.164.6.2113
- The paper
- Collart, M. A., Belin, D., Vassalli, J. D., de Kossodo, S., & Vassalli, P. (1986). Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors. The Journal of experimental medicine. https://doi.org/10.1084/jem.164.6.2113
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
