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In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon.
Open accessAbstract
The (NZB X NZW)F1 mouse is recognized as an important animal model of the human disease systemic lupus erythematosus (SLE). Groups of NZB/W F1 mice were treated either with IFN-gamma or with PBS. The results demonstrate that IFN-treated animals have accelerated development of fatal immune complex glomerulonephritis relative to age-matched controls. On the other hand, administration of mAbs specific for IFN-gamma to such mice from 4 to 7 mo of age resulted in significant remission. Development of both proteinuria and anti-DNA antibodies were delayed and survival at 11 mo was increased from less than 20% to 95% in treated mice relative to controls (p less than or equal to 0.001). These findings may have therapeutic implications for the treatment of SLE.
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Citations
Cited by
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Ishida, H., Muchamuel, T., Sakaguchi, S., Andrade, S., Menon, S., & Howard, M. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.1.305 · Cited by 532
Th1 and Th2 T helper cell subsets affect patterns of injury and outcomes in glomerulonephritis
Holdsworth, S. R., Kitching, A. R., & Tipping, P. G. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00369.x · Cited by 262
VIALLARD, J. F., PELLEGRIN, J. L., RANCHIN, V, SCHAEVERBEKE, T., DEHAIS, J., LONGY-BOURSIER, M., RAGNAUD, J. M., LENG, B., & MOREAU, J. F. (2001) · Clinical and Experimental Immunology · doi:10.1046/j.1365-2249.1999.00766.x · Cited by 247
Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity
Rubtsova, K., Rubtsov, A. V., Cancro, M. P., & Marrack, P. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501209 · Cited by 246
Metadata
- Authors
- Jacob, C. O., van der Meide, P. H., & McDevitt, H. O.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1987-09-01
- Volume
- 166
- Issue
- 3
- Pages
- 798-803
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2160344319
- Cited by
- 386
- References
- 0
- FWCI
- 17.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Jacob, C. O., van der Meide, P. H., & McDevitt, H. O. (1987). In vivo treatment of (NZB X NZW)F1 lupus-like nephritis with monoclonal antibody to gamma interferon. The Journal of experimental medicine. https://doi.org/10.1084/jem.166.3.798
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
