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Human T cell response to the surface antigen of hepatitis B virus (HBsAg). Endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen.
Open accessAbstract
We have studied the antigen specificity and processing requirements of three vaccine-induced cloned human T cell lines specific for HBsAg, the envelope protein of hepatitis B virus. Each T cell line recognized endogenously expressed antigen as well as exogenous antigen. Two clones required endosomal processing, both for exogenous and endogenous antigen; while the other T cell line depended on nonendosomal processing to generate antigenic peptides from both endogenous and exogenous antigen. Thus, the two processing pathways are accessible to exogenous and endogenous antigen. These results suggest that vaccine-induced T cells can participate actively in the immune response to live virus.
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Citations
Cited by
The Biochemistry and Cell Biology of Antigen Processing and Presentation
Germain, R. (1993) · Annual Review of Immunology · doi:10.1146/annurev.immunol.11.1.403 · Cited by 1,020
Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic Mice
Moriyama, T., Guilhot, S., Klopchin, K., Moss, B., Pinkert, C. A., Palmiter, R. D., Brinster, R. L., Kanagawa, O., & Chisari, F. V. (1990) · Science · doi:10.1126/science.1691527 · Cited by 366
Premature Ovarian Failure and Ovarian Autoimmunity
Hoek, A. (1997) · Endocrine Reviews · doi:10.1210/er.18.1.107 · Cited by 259
MHC class II—Restricted presentation of intracellular antigen
Weiss, S., & Bogen, B. (1991) · Cell · doi:10.1016/0092-8674(91)90506-t · Cited by 257
Taylor, G. S., Long, H. M., Haigh, T. A., Larsen, M., Brooks, J., & Rickinson, A. B. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.3746 · Cited by 69
Metadata
- Authors
- Jin, Y., Shih, W. K., & Berkower, I.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1988-07-01
- Volume
- 168
- Issue
- 1
- Pages
- 293-306
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1998135206
- Cited by
- 176
- References
- 0
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Human T cell response to the surface antigen of hepatitis B virus (HBsAg). Endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen. https://app.cochat.ai/papers/10.1084/jem.168.1.293
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- Jin, Y., Shih, W. K., & Berkower, I. (1988). Human T cell response to the surface antigen of hepatitis B virus (HBsAg). Endosomal and nonendosomal processing pathways are accessible to both endogenous and exogenous antigen. The Journal of experimental medicine. https://doi.org/10.1084/jem.168.1.293
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
