The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic Mice
Abstract
The role of the immune response to hepatitis B virus (HBV)-encoded antigens in the pathogenesis of liver cell injury has not been defined because of the absence of appropriate experimental models. HBV envelope transgenic mice were used to show that HBV-encoded antigens are expressed at the hepatocyte surface in a form recognizable by major histocompatibility complex (MHC) class I-restricted, CD8 + cytotoxic T lymphocytes specific for a dominant T cell epitope within the major envelope polypeptide and by envelope-specific antibodies. Both interactions led to the death of the hepatocyte in vivo, providing direct evidence that hepatocellular injury in human HBV infection may also be immunologically mediated.
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Citations
Cites
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Self-citationA Transgenic Mouse Model of the Chronic Hepatitis B Surface Antigen Carrier State
Chisari, F. V., Pinkert, C. A., Milich, D. R., Filippi, P., McLachlan, A., Palmiter, R. D., & Brinster, R. L. (1985) · Science · doi:10.1126/science.3865369 · Cited by 290
Self-citationChisari, F. V., Filippi, P., McLachlan, A., Milich, D. R., Riggs, M., Lee, S., Palmiter, R. D., Pinkert, C. A., & Brinster, R. L. (1986) · Journal of Virology · doi:10.1128/jvi.60.3.880-887.1986 · Cited by 269
Self-citationExpression of class I and class II major histocompatibility complex antigens on human hepatocytes
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Cited by
Viral dynamics in hepatitis B virus infection.
Nowak, M. A., Bonhoeffer, S., Hill, A. M., Boehme, R., Thomas, H. C., & McDade, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4398 · Cited by 1,045
Fas and Fas ligand: lpr and gld mutations
Nagata, S., & Suda, T. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80069-7 · Cited by 892
Maini, M. K., Boni, C., Lee, C. K., Larrubia, J. R., Reignat, S., Ogg, G. S., King, A. S., Herberg, J., Gilson, R., Alisa, A., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1269 · Cited by 800
Purification and characterization of the Fas-ligand that induces apoptosis.
Suda, T., & Nagata, S. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.3.873 · Cited by 507
Pathogenesis of hepatitis B virus infection
Chisari, F. V., Isogawa, M., & Wieland., S. F. (2010) · Pathologie Biologie · doi:10.1016/j.patbio.2009.11.001 · Cited by 414
Self-citation
Metadata
- Authors
- Moriyama, T., Guilhot, S., Klopchin, K., Moss, B., Pinkert, C. A., Palmiter, R. D., Brinster, R. L., Kanagawa, O., & Chisari, F. V.
- Venue
- Science
- Published
- 1990-04-20
- Volume
- 248
- Issue
- 4953
- Pages
- 361-364
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024180247
- Cited by
- 366
- References
- 15
- FWCI
- 16.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic Mice. https://app.cochat.ai/papers/10.1126/science.1691527
- The paper
- Moriyama, T., Guilhot, S., Klopchin, K., Moss, B., Pinkert, C. A., Palmiter, R. D., Brinster, R. L., Kanagawa, O., & Chisari, F. V. (1990). Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic Mice. Science. https://doi.org/10.1126/science.1691527
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
