The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Tolerance to tumor necrosis factor in rats and the relationship to endotoxin tolerance and toxicity.
Open accessAbstract
Treatment of rats with recombinant human TNF initially causes a marked decrease in food intake, a loss of body weight, and a negative nitrogen balance. These alterations normalize with continued twice daily intraperitoneal injections of the same dose. Rats tolerized to TNF in this manner are refractory to a lethal dose of TNF. Also, TNF-pretreated and -tolerized rats have prolonged survival and reversed histopathologic changes after injection of a lethal dose of endotoxin compared with control animals. The TNF-tolerant state is dependent on the dose of TNF used and the length of TNF pretreatment. TNF-induced tolerance is relatively short lived, being present 2-4 d after TNF pretreatment and dissipating by 2 wk. Rats made tolerant to endotoxin are also tolerant to a lethal dose of TNF. A bidirectional crossreacting tolerance exists between TNF and endotoxin. The mechanism of TNF tolerance is unclear, but it does not appear to be due to a humoral immune response or a perturbation of the uptake and clearance of injected TNF.
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Cites
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448
Cited by
Tumor necrosis factor: a pleiotropic cytokine and therapuetic target
Tracey, M. D., & Cerami, P. D. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.491 · Cited by 1,063
Sarraf, P., Frederich, R. C., Turner, E. M., Ma, G., Jaskowiak, N. T., Rivet, D. J., Flier, J. S., Lowell, B. B., Fraker, D. L., & Alexander, H. R. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.1.171 · Cited by 791
Self-citationStress and immunity: An integrated view of relationships between the brain and the immune system
Dantzer, R., & Kelley, K. W. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90345-7 · Cited by 534
Rock, C. S., & Lowry, S. F. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90146-d · Cited by 503
Molecular mechanisms of innate memory and tolerance to LPS
Seeley, J. J., & Ghosh, S. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3mr0316-118rr · Cited by 367
Metadata
- Authors
- Fraker, D. L., Stovroff, M. C., Merino, M. J., & Norton, J. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1988-07-01
- Volume
- 168
- Issue
- 1
- Pages
- 95-105
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W1977130245
- Cited by
- 196
- References
- 2
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Fraker, D. L., Stovroff, M. C., Merino, M. J., & Norton, J. A. (1988). Tolerance to tumor necrosis factor in rats and the relationship to endotoxin tolerance and toxicity. The Journal of experimental medicine. https://doi.org/10.1084/jem.168.1.95
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