The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes.
Open accessAbstract
In this report, we describe a novel activation antigen that appears very early after T cell activation and is absent in resting lymphocytes, through which agonistic proliferative signals can be triggered by mAb binding. It has been designated as activation inducer molecule (AIM) and is a disulphide-linked heterodimeric structure containing two polypeptide chains of Mr 33,000 and 27,000. The expression of AIM can be induced by different activation stimuli such as PMA, PHA, or anti-CD3 mAb, but not by the Ca2+ ionophore A23187, and it precedes the expression of other activation molecules such as 4F2 or the IL-2-R. Once AIM antigens are expressed on lymphocytes after stimulation with submitogenic doses of PMA, the binding of anti-AIM mAbs triggers a strong proliferative response. Furthermore, a comitogenic effect of the anti-AIM mAbs is exerted in the presence of either PHA or anti-CD3 mAb. The activation of lymphocytes through AIM antigens induces both IL-2 and IL-2-R receptor synthesis and is inhibited by anti-IL-2-R mAbs.
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Cites
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Cited by
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
Agata, Y., Kawasaki, A., Nishimura, H., Ishida, Y., Tsubat, T., Yagita, H., & Honjo, T. (1996) · International Immunology · doi:10.1093/intimm/8.5.765 · Cited by 1,589
The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells
Testi, R., D'Ambrosio, D., De Maria, R., & Santoni, A. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90193-7 · Cited by 451
Flow-cytometric analysis of rare antigen-specific T cells
Bacher, P., & Scheffold, A. (2013) · Cytometry Part A · doi:10.1002/cyto.a.22317 · Cited by 155
Labiano, S., Meléndez-Rodríguez, F., Palazón, A., Teijeira, Á., Garasa, S., Etxeberria, I., Aznar, M. Á., Sánchez-Paulete, A. R., Azpilikueta, A., Bolaños, E., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1283468 · Cited by 35
Self-citation
Metadata
- Authors
- Cebrián, M., Yagüe, E., Rincón, M., López-Botet, M., de Landázuri, M. O., & Sánchez-Madrid, F.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1988-11-01
- Volume
- 168
- Issue
- 5
- Pages
- 1621-1637
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2060819744
- Cited by
- 277
- References
- 35
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Cebrián, M., Yagüe, E., Rincón, M., López-Botet, M., de Landázuri, M. O., & Sánchez-Madrid, F. (1988). Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes. The Journal of experimental medicine. https://doi.org/10.1084/jem.168.5.1621
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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